Major p53 immunohistochemical patterns in in situ and invasive squamous cell carcinomas of the vulva and correlation with TP53 mutation status

[1]  H. Mackay,et al.  HPV-independent Vulvar Squamous Cell Carcinoma is Associated With Significantly Worse Prognosis Compared With HPV-associated Tumors , 2019, International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists.

[2]  M. Nucci,et al.  Classic Vulvar Intraepithelial Neoplasia With Superimposed Lichen Simplex Chronicus: A Unique Variant Mimicking Differentiated Vulvar Intraepithelial Neoplasia , 2019, International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists.

[3]  F. L. Sand,et al.  The prognostic value of p16 and p53 expression for survival after vulvar cancer: A systematic review and meta-analysis. , 2019, Gynecologic oncology.

[4]  M. Köbel,et al.  Interpretation of P53 Immunohistochemistry in Endometrial Carcinomas: Toward Increased Reproducibility , 2018, International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists.

[5]  M. Cuello,et al.  Cancer of the vulva , 2018, International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics.

[6]  H. V. van Doorn,et al.  Differentiated vulvar intraepithelial neoplasia (dVIN): the most helpful histological features and the utility of cytokeratins 13 and 17 , 2018, Virchows Archiv.

[7]  S. Arulkumaran,et al.  Planning and implementation of a FIGO postpartum intrauterine device initiative in six countries , 2018, International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics.

[8]  P. Bult,et al.  Vulvar cancer: Two pathways with different localization and prognosis. , 2018, Gynecologic oncology.

[9]  A. Lapuk,et al.  Formalin fixation increases deamination mutation signature but should not lead to false positive mutations in clinical practice , 2018, PloS one.

[10]  M. Herfs,et al.  Accentuated p53 staining in usual type vulvar dysplasia-A potential diagnostic pitfall. , 2017, Pathology, research and practice.

[11]  J. Ordi,et al.  Genomic Characterization of Vulvar (Pre)cancers Identifies Distinct Molecular Subtypes with Prognostic Significance , 2017, Clinical Cancer Research.

[12]  S. Regauer,et al.  Analysis of full coding sequence of the TP53 gene in invasive vulvar cancers: Implications for therapy. , 2017, Gynecologic oncology.

[13]  A. Talhouk,et al.  Human papillomavirus (HPV)‐independent vulvar squamous cell carcinoma has a worse prognosis than HPV‐associated disease: a retrospective cohort study , 2017, Histopathology.

[14]  Lauren L. Ritterhouse,et al.  Differentiated exophytic vulvar intraepithelial lesions are genetically distinct from keratinizing squamous cell carcinomas and contain mutations in PIK3CA , 2017, Modern Pathology.

[15]  Ronald W. Jones,et al.  The Natural History of Vulvar Intraepithelial Neoplasia, Differentiated Type: Evidence for Progression and Diagnostic Challenges , 2016, International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists.

[16]  K. Gaarenstroom,et al.  Risk factors and treatment for recurrent vulvar squamous cell carcinoma. , 2016, Critical reviews in oncology/hematology.

[17]  F. Lucas,et al.  Biomarkers p16, Human Papillomavirus and p53 Predict Recurrence and Survival in Early Stage Squamous Cell Carcinoma of the Vulva , 2016, Journal of lower genital tract disease.

[18]  R. Murali,et al.  Squamous precursor lesions of the vulva: current classification and diagnostic challenges. , 2016, Pathology.

[19]  M. Masson,et al.  Structure of the E6/E6AP/p53 complex required for HPV-mediated degradation of p53 , 2015, Nature.

[20]  N. Hacker,et al.  Cancer of the vulva , 2012, International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics.

[21]  E. Oliva,et al.  Squamous Cell Carcinoma of the Vulva: A Subclassification of 97 Cases by Clinicopathologic, Immunohistochemical, and Molecular Features (p16, p53, and EGFR) , 2015, The American journal of surgical pathology.

[22]  J. McAlpine,et al.  Expanding the Morphologic Spectrum of Differentiated VIN (dVIN) Through Detailed Mapping of Cases With p53 Loss , 2015, The American journal of surgical pathology.

[23]  C. Potten,et al.  The Development of Epithelial Stem Cell Concepts , 2014 .

[24]  C. Potten,et al.  Chapter 39 – The Development of Epithelial Stem Cell Concepts , 2013 .

[25]  H. Brustmann,et al.  Expression of human telomerase reverse transcriptase in vulvar intraepithelial neoplasia and squamous cell carcinoma: an immunohistochemical study with survivin and p53. , 2012, Archives of pathology & laboratory medicine.

[26]  J. T. Cox,et al.  The Lower Anogenital Squamous Terminology Standardization Project for HPV-Associated Lesions: background and consensus recommendations from the College of American Pathologists and the American Society for Colposcopy and Cervical Pathology. , 2012, Journal of lower genital tract disease.

[27]  R. Simon,et al.  Role of TP53 Mutations in Vulvar Carcinomas , 2011, International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists.

[28]  J. A. van der Laak,et al.  High levels of p53 expression correlate with DNA aneuploidy in (pre)malignancies of the vulva. , 2010, Human pathology.

[29]  C. Crum,et al.  Differentiated vulvar intraepithelial neoplasia contains Tp53 mutations and is genetically linked to vulvar squamous cell carcinoma , 2010, Modern Pathology.

[30]  B. Lloveras,et al.  HPV-negative Vulvar Intraepithelial Neoplasia (VIN) With Basaloid Histologic Pattern: An Unrecognized Variant of Simplex (Differentiated) VIN , 2009, The American journal of surgical pathology.

[31]  P. D. de Wilde,et al.  A panel of p16INK4A, MIB1 and p53 proteins can distinguish between the 2 pathways leading to vulvar squamous cell carcinoma , 2008, International journal of cancer.

[32]  N. Mulvany,et al.  Differentiated Intraepithelial Neoplasia of the Vulva , 2008, International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists.

[33]  B. Liegl,et al.  p53 immunostaining in lichen sclerosus is related to ischaemic stress and is not a marker of differentiated vulvar intraepithelial neoplasia (d‐VIN) , 2006, Histopathology.

[34]  P. D. de Wilde,et al.  Vulvar Squamous Cell Carcinoma is a Multifactorial Disease Following Two Separate and Independent Pathways , 2006, International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists.

[35]  S. Cajal,et al.  Immunohistochemical Staining for p16 and p53 in Premalignant and Malignant Epithelial Lesions of the Vulva , 2004, International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists.

[36]  S. Granter,et al.  Vulvar Acanthosis With Altered Differentiation: A Precursor to Verrucous Carcinoma? , 2004, The American journal of surgical pathology.

[37]  J. Crow,et al.  TP53 mutations in vulval lichen sclerosus adjacent to squamous cell carcinoma of the vulva , 2003, British Journal of Cancer.

[38]  R. Ramsay,et al.  Overexpression of wild-type p53 in lichen sclerosus adjacent to human papillomavirus-negative vulvar cancer. , 2002, The Journal of investigative dermatology.

[39]  Dianne Miller,et al.  Vulvar squamous cell carcinoma in young women: a clinicopathologic study of 21 cases. , 2002, Gynecologic oncology.

[40]  Bin Yang,et al.  Vulvar intraepithelial neoplasia of the simplex (differentiated) type: a clinicopathologic study including analysis of HPV and p53 expression. , 2000, The American journal of surgical pathology.

[41]  E. Lerma,et al.  Squamous cell carcinoma of the vulva: study of ploidy, HPV, p53, and pRb. , 1999, International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists.

[42]  J. Nesland,et al.  p53 Protein expression in squamous cell carcinoma of the vulva , 1999, Cancer.

[43]  W. Gajewski,et al.  S-Phase fraction, p53, and HER-2/neu status as predictors of nodal metastasis in early vulvar cancer. , 1997, Gynecologic oncology.

[44]  G. Fleuren,et al.  p53 protein overexpression is common and independent of human papillomavirus infection in squamous cell carcinoma of the vulva , 1997, Cancer.

[45]  F. Pontén,et al.  Two distinct p53 immunohistochemical patterns in human squamous‐cell skin cancer, precursors and normal epidermis , 1996, International journal of cancer.

[46]  Kathleen R. Cho,et al.  p53 mutations and clonality in vulvar carcinomas and squamous hyperplasias: evidence suggesting that squamous hyperplasias do not serve as direct precursors of human papillomavirus-negative vulvar carcinomas. , 1996, Human pathology.

[47]  F. Pontén,et al.  Human epidermal cancer and accompanying precursors have identical p53 mutations different from p53 mutations in adjacent areas of clonally expanded non-neoplastic keratinocytes. , 1996, Oncogene.

[48]  P. Jeffrey,et al.  Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations. , 1994, Science.

[49]  K. Shah,et al.  Probable Nonpapillomavirus Etiology of Squamous Cell Carcinoma of the Vulva in Older Women: A Clinicopathologic Study Using In Situ Hybridization and Polymerase Chain Reaction , 1991, International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists.

[50]  F. J. Taussig.  Cancer of the Vulva , 1940 .