Chronic hepatitis C infection and sex hormone levels: effect of disease severity and recombinant interferon‐α therapy

Background: We aimed to investigate the associations between androgen status and markers of liver disease severity and to determine the effect of interferon‐α (IFN‐α) treatment on sex hormone levels in the context of hepatitis C infection.

[1]  C. Ferri,et al.  Erectile dysfunction and hepatitis C virus infection. , 2002, JAMA.

[2]  E. Brunt,et al.  Grading and staging the histopathological lesions of chronic hepatitis: The Knodell histology activity index and beyond , 2000, Hepatology.

[3]  L. Valladares,et al.  Sex hormone-binding globulin in non-cirrhotic alcoholic patients during early withdrawal and after longer abstinence. , 1999, Alcohol and alcoholism.

[4]  A. Vermeulen,et al.  A critical evaluation of simple methods for the estimation of free testosterone in serum. , 1999, The Journal of clinical endocrinology and metabolism.

[5]  A. Mariano,et al.  Long-Term Interferon-α Therapy Does Not Affect Sex Hormones in Males with Chronic Hepatitis C , 1997 .

[6]  P. Vallone,et al.  Oestradiol and testosterone blood levels in patients with viral cirrhosis and hepatocellular carcinoma , 1997, European journal of gastroenterology & hepatology.

[7]  P. Marcellin,et al.  Reversibility of thyroid dysfunction induced by recombinant alpha interferon in chronic hepatitis C , 1993, Clinical endocrinology.

[8]  R. Franceschini,et al.  Sex Hormones and Sex Hormone-Binding Globulin in Males with Chronic Viral Hepatitis During Recombinant Interferon-α2b Therapy , 1993 .

[9]  P. Marcellin,et al.  Sustained hypothyroidism induced by recombinant alpha interferon in patients with chronic hepatitis C. , 1992, Gut.

[10]  B. Weintraub,et al.  Development of thyroid disease during therapy of chronic viral hepatitis with interferon alfa. , 1992, Gastroenterology.

[11]  P. Zucchetta,et al.  Sex hormones and sex hormone binding globulin in males with compensated and decompensated cirrhosis of the liver. , 1989, Acta endocrinologica.

[12]  T. Tötterman,et al.  Thyroid autoimmunity in patients on long term therapy with leukocyte-derived interferon. , 1986, The Journal of clinical endocrinology and metabolism.

[13]  K. Cantell,et al.  Treatment with preparations of human leukocyte interferon decreases serum testosterone concentrations in men. , 1986, International journal of cancer.

[14]  Neil Kaplowitz,et al.  Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis , 1981, Hepatology.

[15]  D. V. van Thiel,et al.  Evidence for a defect in pituitary secretion of luteinizing hormone in chronic alcoholic men. , 1978, The Journal of clinical endocrinology and metabolism.

[16]  G. Gordon,et al.  Conversion of androgens to estrogens in cirrhosis of the liver. , 1975, The Journal of clinical endocrinology and metabolism.

[17]  E. Rhoden,et al.  MEDICAL PROGRESS: RISKS OF TESTOSTERONE REPLACEMENT THERAPY AND RECOMMENDATIONS FOR MONITORING , 2004 .

[18]  P. Del Monte,et al.  Endocrine evaluation in patients treated with interferon-alpha for chronic hepatitis C. , 1995, Hormone research.

[19]  P. Balladur,et al.  Effect of liver transplantation on sex-hormone disorders in male patients with alcohol-induced or post-viral hepatitis advanced liver disease. , 1994, Journal of hepatology.