Interleukin 17 is a chief orchestrator of immunity

[1]  Ruth Gamble Lineages , 2018, Oxford Scholarship Online.

[2]  B. Silva-Santos,et al.  IL-17+ γδ T cells as kick-starters of inflammation , 2017, Nature Immunology.

[3]  S. Gaffen,et al.  IL-17 Signaling: The Yin and the Yang. , 2017, Trends in immunology.

[4]  Y. Belkaid,et al.  On-going Mechanical Damage from Mastication Drives Homeostatic Th17 Cell Responses at the Oral Barrier , 2017, Immunity.

[5]  D. Gladman,et al.  Ixekizumab, an interleukin-17A specific monoclonal antibody, for the treatment of biologic-naive patients with active psoriatic arthritis: results from the 24-week randomised, double-blind, placebo-controlled and active (adalimumab)-controlled period of the phase III trial SPIRIT-P1 , 2016, Annals of the rheumatic diseases.

[6]  Quynh-Mai Pham,et al.  IL-17A–producing resident memory γδ T cells orchestrate the innate immune response to secondary oral Listeria monocytogenes infection , 2016, Proceedings of the National Academy of Sciences.

[7]  A. Kipnis,et al.  The Role of Neutrophils in the Induction of Specific Th1 and Th17 during Vaccination against Tuberculosis , 2016, Front. Microbiol..

[8]  Ta-Chiang Liu,et al.  Genetics and Pathogenesis of Inflammatory Bowel Disease. , 2016, Annual review of pathology.

[9]  M. Veldhoen,et al.  Tbet or Continued RORγt Expression Is Not Required for Th17-Associated Immunopathology , 2016, The Journal of Immunology.

[10]  J. Koo,et al.  Ixekizumab for the Treatment of Psoriasis: A Review of Phase III Trials , 2016, Dermatology and Therapy.

[11]  J. Koo,et al.  Brodalumab for the Treatment of Psoriasis: A Review of Phase III Trials , 2016, Dermatology and Therapy.

[12]  J. Kelsen,et al.  Transient inhibition of ROR-γt therapeutically limits intestinal inflammation by reducing TH17 cells and preserving group 3 innate lymphoid cells , 2016, Nature Medicine.

[13]  P. Ho,et al.  IL-17a and IL-22 Induce Expression of Antimicrobials in Gastrointestinal Epithelial Cells and May Contribute to Epithelial Cell Defense against Helicobacter pylori , 2016, PloS one.

[14]  I. McInnes,et al.  Therapeutic Targeting of IL-17 and IL-23 Cytokines in Immune-Mediated Diseases. , 2016, Annual review of medicine.

[15]  M. Dougados,et al.  Secukinumab, an Interleukin-17A Inhibitor, in Ankylosing Spondylitis. , 2015, The New England journal of medicine.

[16]  Sabyasachi Das,et al.  Characterization of Lamprey IL-17 Family Members and Their Receptors , 2015, The Journal of Immunology.

[17]  Judy H. Cho,et al.  Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations , 2015, Nature Genetics.

[18]  Juan R. Cubillos-Ruiz,et al.  ER Stress Sensor XBP1 Controls Anti-tumor Immunity by Disrupting Dendritic Cell Homeostasis , 2015, Cell.

[19]  T. Schoeb,et al.  Th17 cells give rise to Th1 cells that are required for the pathogenesis of colitis , 2015, Proceedings of the National Academy of Sciences.

[20]  G. Ho Faculty Opinions recommendation of Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology. , 2015 .

[21]  Simon C Watkins,et al.  Oral-resident natural Th17 cells and γδ T cells control opportunistic Candida albicans infections , 2014, The Journal of experimental medicine.

[22]  M. Veldhoen,et al.  Cellular Plasticity of CD4+ T Cells in the Intestine , 2014, Front. Immunol..

[23]  Sarah L. Gaffen,et al.  The IL-23–IL-17 immune axis: from mechanisms to therapeutic testing , 2014, Nature Reviews Immunology.

[24]  F. Bernard,et al.  Inhibition of Keratinocyte Differentiation by the Synergistic Effect of IL-17A, IL-22, IL-1α, TNFα and Oncostatin M , 2014, PloS one.

[25]  Yan Gao,et al.  T cell-intrinsic role of IL-6 signaling in primary and memory responses , 2014, eLife.

[26]  Henrique Veiga-Fernandes,et al.  Differentiation of Type 1 ILCs from a Common Progenitor to All Helper-like Innate Lymphoid Cell Lineages , 2014, Cell.

[27]  L. Bont,et al.  Local IL-17A Potentiates Early Neutrophil Recruitment to the Respiratory Tract during Severe RSV Infection , 2013, PloS one.

[28]  M. Veldhoen,et al.  The aryl hydrocarbon receptor in innate T cell immunity , 2013, Seminars in Immunopathology.

[29]  M. Oukka,et al.  IL-23R+ innate lymphoid cells induce colitis via interleukin-22-dependent mechanism , 2013, Mucosal Immunology.

[30]  S. Orlow,et al.  IL-17 and TNF synergistically modulate cytokine expression while suppressing melanogenesis: potential relevance to psoriasis , 2013, The Journal of investigative dermatology.

[31]  N. Yosef,et al.  Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells , 2013, Nature.

[32]  D. M. van der Heijde,et al.  Efficacy and safety of secukinumab, a fully human anti-interleukin-17A monoclonal antibody, in patients with moderate-to-severe psoriatic arthritis: a 24-week, randomised, double-blind, placebo-controlled, phase II proof-of-concept trial , 2013, Annals of the rheumatic diseases.

[33]  R. D. Hatton,et al.  Th22 cells are an important source of IL-22 for host protection against enteropathogenic bacteria. , 2012, Immunity.

[34]  Graham M Lord,et al.  The Transcription Factor T-bet Regulates Intestinal Inflammation Mediated by Interleukin-7 Receptor+ Innate Lymphoid Cells , 2012, Immunity.

[35]  Burkhard Becher,et al.  IL-1β mediates chronic intestinal inflammation by promoting the accumulation of IL-17A secreting innate lymphoid cells and CD4+ Th17 cells , 2012, The Journal of experimental medicine.

[36]  S. Rutz,et al.  Regulation of epithelial immunity by IL-17 family cytokines. , 2012, Trends in immunology.

[37]  Patrick Durez,et al.  Efficacy and safety of secukinumab in patients with rheumatoid arthritis: a phase II, dose-finding, double-blind, randomised, placebo controlled study , 2012, Annals of the rheumatic diseases.

[38]  Z. Yao,et al.  IL-17A Synergizes with IFN-γ to Upregulate iNOS and NO Production and Inhibit Chlamydial Growth , 2012, PloS one.

[39]  G. Newton,et al.  IL-17 and TNF-α Sustain Neutrophil Recruitment during Inflammation through Synergistic Effects on Endothelial Activation , 2012, The Journal of Immunology.

[40]  Marc Vandemeulebroecke,et al.  Secukinumab, a human anti-IL-17A monoclonal antibody, for moderate to severe Crohn's disease: unexpected results of a randomised, double-blind placebo-controlled trial , 2012, Gut.

[41]  Jin-Young Park,et al.  Interleukin-22 promotes osteoclastogenesis in rheumatoid arthritis through induction of RANKL in human synovial fibroblasts. , 2012, Arthritis and rheumatism.

[42]  J. Renauld,et al.  IL-22 Mediates Host Defense against an Intestinal Intracellular Parasite in the Absence of IFN-γ at the Cost of Th17-Driven Immunopathology , 2012, The Journal of Immunology.

[43]  T. Glant,et al.  Neutralization of IL-17 ameliorates uveitis but damages photoreceptors in a murine model of spondyloarthritis , 2012, Arthritis Research & Therapy.

[44]  S. Rutz,et al.  Transcription factor c-Maf mediates the TGF-β-dependent suppression of IL-22 production in TH17 cells , 2011, Nature Immunology.

[45]  S. Gaffen Life before Seventeen: Cloning of the IL-17 Receptor , 2011, The Journal of Immunology.

[46]  J. Renauld,et al.  IL-22 Is Required for Imiquimod-Induced Psoriasiform Skin Inflammation in Mice , 2011, The Journal of Immunology.

[47]  G. Semenza,et al.  Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1 , 2011, Cell.

[48]  J. O’Shea,et al.  T helper 17 cell heterogeneity and pathogenicity in autoimmune disease. , 2011, Trends in immunology.

[49]  D. Green,et al.  HIF1α–dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells , 2011, The Journal of experimental medicine.

[50]  S. Travis,et al.  IL-23–responsive innate lymphoid cells are increased in inflammatory bowel disease , 2011, The Journal of experimental medicine.

[51]  A. Skapenko,et al.  Interleukin 22 serum levels are associated with radiographic progression in rheumatoid arthritis , 2011, Annals of the rheumatic diseases.

[52]  R. Caspi,et al.  Faculty Opinions recommendation of Fate mapping of IL-17-producing T cells in inflammatory responses. , 2011 .

[53]  M. Willart,et al.  Dual Role of IL-22 in allergic airway inflammation and its cross-talk with IL-17A. , 2011, American journal of respiratory and critical care medicine.

[54]  C. Bodemer,et al.  Chronic Mucocutaneous Candidiasis in Humans with Inborn Errors of Interleukin-17 Immunity , 2011, Science.

[55]  E. Hwang,et al.  Prominent Bone Loss Mediated by RANKL and IL-17 Produced by CD4+ T Cells in TallyHo/JngJ Mice , 2011, PloS one.

[56]  S. Rutz,et al.  Regulation and functions of the IL-10 family of cytokines in inflammation and disease. , 2011, Annual review of immunology.

[57]  S. Chimenti,et al.  Integrative responses to IL-17 and TNF-α in human keratinocytes account for key inflammatory pathogenic circuits in psoriasis. , 2011, The Journal of investigative dermatology.

[58]  P. Miossec,et al.  Effects of interleukin (IL)-17A and IL-17F in human rheumatoid arthritis synoviocytes , 2011, Annals of the rheumatic diseases.

[59]  W. Wilson,et al.  A novel role for IL-22R1 as a driver of inflammation. , 2011, Blood.

[60]  Todd Davidson,et al.  Generation of Pathogenic Th17 Cells in the Absence of TGF-β Signaling , 2010, Nature.

[61]  B. '. ’t Hart,et al.  Effects of Early IL-17A Neutralization on Disease Induction in a Primate Model of Experimental Autoimmune Encephalomyelitis , 2010, Journal of Neuroimmune Pharmacology.

[62]  B. Ryffel,et al.  Interleukin 17 receptor signaling is deleterious during Toxoplasma gondii infection in susceptible BL6 mice. , 2010, The Journal of infectious diseases.

[63]  A. Shafferman,et al.  The Involvement of IL-17A in the Murine Response to Sub-Lethal Inhalational Infection with Francisella tularensis , 2010, PloS one.

[64]  D. Artis,et al.  Pathological versus protective functions of IL-22 in airway inflammation are regulated by IL-17A , 2010, The Journal of experimental medicine.

[65]  F. Bernard,et al.  Skin Inflammation Induced by the Synergistic Action of IL-17A, IL-22, Oncostatin M, IL-1α, and TNF-α Recapitulates Some Features of Psoriasis , 2010, The Journal of Immunology.

[66]  M. Kawaguchi,et al.  IL-17A and IL-17F stimulate chemokines via MAPK pathways (ERK1/2 and p38 but not JNK) in mouse cultured mesangial cells: synergy with TNF-alpha and IL-1beta. , 2010, American journal of physiology. Renal physiology.

[67]  J. D. Di Santo,et al.  Th17 Cells Are the Dominant T Cell Subtype Primed by Shigella flexneri Mediating Protective Immunity , 2010, The Journal of Immunology.

[68]  J. Alcorn,et al.  Critical Role of IL-17RA in Immunopathology of Influenza Infection , 2009, The Journal of Immunology.

[69]  R. Pawankar,et al.  Synergistic Induction of Macrophage Inflammatory Protein-3α/CCL20 Production by Interleukin-17A and Tumor Necrosis Factor-α in Nasal Polyp Fibroblasts , 2009, The World Allergy Organization journal.

[70]  M. Veldhoen,et al.  Interleukin-17-producing gammadelta T cells selectively expand in response to pathogen products and environmental signals. , 2009, Immunity.

[71]  M. Banerjee,et al.  Phenotype, distribution, generation, and functional and clinical relevance of Th17 cells in the human tumor environments. , 2009, Blood.

[72]  Margarida Saraiva,et al.  Interleukin-10 Production by Th1 Cells Requires Interleukin-12-Induced STAT4 Transcription Factor and ERK MAP Kinase Activation by High Antigen Dose , 2009, Immunity.

[73]  Jianxu Li,et al.  Erratum: Dual nature of the adaptive immune system in lampreys , 2009 .

[74]  W. Zou,et al.  Endogenous IL-17 contributes to reduced tumor growth and metastasis. , 2009, Blood.

[75]  Hua Yu,et al.  IL-17 can promote tumor growth through an IL-6–Stat3 signaling pathway , 2009, The Journal of experimental medicine.

[76]  S. Gaffen Structure and signalling in the IL-17 receptor family , 2009, Nature Reviews Immunology.

[77]  Richard A Flavell,et al.  A protective function for interleukin 17A in T cell–mediated intestinal inflammation , 2009, Nature Immunology.

[78]  Brantley R. Herrin,et al.  Dual Nature of the Adaptive Immune System in Lampreys , 2009, Nature.

[79]  H. Volk,et al.  IL-22 and IL-20 are key mediators of the epidermal alterations in psoriasis while IL-17 and IFN-γ are not , 2009, Journal of Molecular Medicine.

[80]  Thomas Korn,et al.  IL-17 and Th17 Cells. , 2009, Annual review of immunology.

[81]  J. Pober,et al.  Interleukin-17 and Interferon-γ Are Produced Concomitantly by Human Coronary Artery–Infiltrating T Cells and Act Synergistically on Vascular Smooth Muscle Cells , 2009, Circulation.

[82]  R. Écochard,et al.  Genome-Wide Comparison between IL-17A- and IL-17F-Induced Effects in Human Rheumatoid Arthritis Synoviocytes1 , 2009, The Journal of Immunology.

[83]  S. Gaffen,et al.  Th17 cells and IL-17 receptor signaling are essential for mucosal host defense against oral candidiasis , 2009, The Journal of experimental medicine.

[84]  J. Renauld,et al.  Proinflammatory role of the Th17 cytokine interleukin-22 in collagen-induced arthritis in C57BL/6 mice. , 2009, Arthritis and rheumatism.

[85]  M. Veldhoen,et al.  Natural agonists for aryl hydrocarbon receptor in culture medium are essential for optimal differentiation of Th17 T cells , 2009, The Journal of experimental medicine.

[86]  C. Sasakawa,et al.  Differential roles of interleukin-17A and -17F in host defense against mucoepithelial bacterial infection and allergic responses. , 2009, Immunity.

[87]  O. Mandelboim,et al.  Microbial flora drives interleukin 22 production in intestinal NKp46+ cells that provide innate mucosal immune defense. , 2008, Immunity.

[88]  S. Nakae,et al.  The roles of IL‐17A in inflammatory immune responses and host defense against pathogens , 2008, Immunological reviews.

[89]  M. Hashizume,et al.  IL-6 trans-signalling directly induces RANKL on fibroblast-like synovial cells and is involved in RANKL induction by TNF-alpha and IL-17. , 2008, Rheumatology.

[90]  J. Kolls,et al.  Cytokine-mediated regulation of antimicrobial proteins , 2008, Nature Reviews Immunology.

[91]  Judy H. Cho,et al.  Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease , 2008, Nature Genetics.

[92]  V. Bronte Th17 and cancer: friends or foes? , 2008, Blood.

[93]  S. Tangye,et al.  Deficiency of Th17 cells in hyper IgE syndrome due to mutations in STAT3 , 2008, The Journal of experimental medicine.

[94]  M. Leppert,et al.  Novel signal transducer and activator of transcription 3 (STAT3) mutations, reduced T(H)17 cell numbers, and variably defective STAT3 phosphorylation in hyper-IgE syndrome. , 2008, The Journal of allergy and clinical immunology.

[95]  S. Gaffen,et al.  The Interleukin-17 Receptor Plays a Gender-Dependent Role in Host Protection against Porphyromonas gingivalis-Induced Periodontal Bone Loss , 2008, Infection and Immunity.

[96]  R. Broaddus,et al.  Regulation of inflammatory responses by IL-17F , 2008, The Journal of experimental medicine.

[97]  M. Ostrowski,et al.  Virus-Specific Interleukin-17-Producing CD4+ T Cells Are Detectable in Early Human Immunodeficiency Virus Type 1 Infection , 2008, Journal of Virology.

[98]  J. Lord,et al.  Prolonged, granulocyte–macrophage colony-stimulating factor-dependent, neutrophil survival following rheumatoid synovial fibroblast activation by IL-17 and TNFalpha , 2008, Arthritis research & therapy.

[99]  S. Sa,et al.  Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens , 2008, Nature Medicine.

[100]  M. Fei,et al.  IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia , 2008, Nature Medicine.

[101]  J. Oakes,et al.  IL‐17 receptor signaling influences virus‐induced corneal inflammation , 2008, Journal of leukocyte biology.

[102]  Robert W. Williams,et al.  Interleukin 17–producing T helper cells and interleukin 17 orchestrate autoreactive germinal center development in autoimmune BXD2 mice , 2008, Nature Immunology.

[103]  Lisa C. Zaba,et al.  Amelioration of epidermal hyperplasia by TNF inhibition is associated with reduced Th17 responses , 2007, The Journal of experimental medicine.

[104]  B. Becher,et al.  IL-22 Is Expressed by Th17 Cells in an IL-23-Dependent Fashion, but Not Required for the Development of Autoimmune Encephalomyelitis1 , 2007, The Journal of Immunology.

[105]  F. Morel,et al.  A role for T cell‐derived interleukin 22 in psoriatic skin inflammation , 2007, Clinical and experimental immunology.

[106]  M. Veldhoen,et al.  Th17 T cells: linking innate and adaptive immunity. , 2007, Seminars in immunology.

[107]  P. Tak,et al.  Inflammation and ectopic lymphoid structures in rheumatoid arthritis synovial tissues dissected by genomics technology: identification of the interleukin-7 signaling pathway in tissues with lymphoid neogenesis. , 2007, Arthritis and rheumatism.

[108]  C. Griffiths,et al.  Pathogenesis and clinical features of psoriasis , 2007, The Lancet.

[109]  N. Bostanci,et al.  Regulation of RANKL and OPG gene expression in human gingival fibroblasts and periodontal ligament cells by Porphyromonas gingivalis: a putative role of the Arg-gingipains. , 2007, Microbial pathogenesis.

[110]  Brigitta Stockinger,et al.  Differentiation and function of Th17 T cells. , 2007, Current opinion in immunology.

[111]  D. Jarrossay,et al.  Surface phenotype and antigenic specificity of human interleukin 17–producing T helper memory cells , 2007, Nature Immunology.

[112]  J. Ross,et al.  Identification of an Interleukin 17F/17A Heterodimer in Activated Human CD4+ T Cells* , 2007, Journal of Biological Chemistry.

[113]  S. Gaffen,et al.  An essential role for IL-17 in preventing pathogen-initiated bone destruction: recruitment of neutrophils to inflamed bone requires IL-17 receptor-dependent signals. , 2007, Blood.

[114]  J. Shellito,et al.  Interleukin-23 (IL-23)-IL-17 Cytokine Axis in Murine Pneumocystis carinii Infection , 2007, Infection and Immunity.

[115]  R. Locksley,et al.  IL-23 and IL-17 in the establishment of protective pulmonary CD4+ T cell responses after vaccination and during Mycobacterium tuberculosis challenge , 2007, Nature Immunology.

[116]  P. Valdez,et al.  Interleukin-22, a TH17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis , 2007, Nature.

[117]  Steven J. Schrodi,et al.  A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes. , 2007, American journal of human genetics.

[118]  Kathleen M. Smith,et al.  IL-23 stimulates epidermal hyperplasia via TNF and IL-20R2–dependent mechanisms with implications for psoriasis pathogenesis , 2006, The Journal of experimental medicine.

[119]  Y. Kadono,et al.  Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction , 2006, The Journal of experimental medicine.

[120]  C. Uyttenhove,et al.  Development of an anti‐IL‐17A auto‐vaccine that prevents experimental auto‐immune encephalomyelitis , 2006, European journal of immunology.

[121]  L. Fouser,et al.  Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides , 2006, The Journal of experimental medicine.

[122]  J. Flynn,et al.  IL-17 Production Is Dominated by γδ T Cells rather than CD4 T Cells during Mycobacterium tuberculosis Infection1 , 2006, The Journal of Immunology.

[123]  R. J. Hocking,et al.  Signals mediated by transforming growth factor-β initiate autoimmune encephalomyelitis, but chronic inflammation is needed to sustain disease , 2006, Nature Immunology.

[124]  M. Neurath,et al.  Cutting edge: IL-23 cross-regulates IL-12 production in T cell-dependent experimental colitis. , 2006, Journal of immunology.

[125]  Zihua Hu,et al.  Identification of Common Transcriptional Regulatory Elements in Interleukin-17 Target Genes* , 2006, Journal of Biological Chemistry.

[126]  M. Veldhoen,et al.  TGFbeta1, a "Jack of all trades": the link with pro-inflammatory IL-17-producing T cells. , 2006, Trends in immunology.

[127]  J. Derry,et al.  Cutting Edge: Interleukin 17 Signals through a Heteromeric Receptor Complex , 2006, The Journal of Immunology.

[128]  T. Mcclanahan,et al.  IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6. , 2006, The Journal of clinical investigation.

[129]  J. Kolls,et al.  Critical role of IL‐17 receptor signaling in acute TNBS‐induced colitis , 2006, Inflammatory bowel diseases.

[130]  V. Lievin-Le Moal,et al.  The Front Line of Enteric Host Defense against Unwelcome Intrusion of Harmful Microorganisms: Mucins, Antimicrobial Peptides, and Microbiota , 2006, Clinical Microbiology Reviews.

[131]  Ying Wang,et al.  A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17 , 2005, Nature Immunology.

[132]  R. D. Hatton,et al.  Interleukin 17–producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages , 2005, Nature Immunology.

[133]  L. Joosten,et al.  Interleukin-17 receptor deficiency results in impaired synovial expression of interleukin-1 and matrix metalloproteinases 3, 9, and 13 and prevents cartilage destruction during chronic reactivated streptococcal cell wall-induced arthritis. , 2005, Arthritis and rheumatism.

[134]  S. Khader,et al.  IL-23 Compensates for the Absence of IL-12p70 and Is Essential for the IL-17 Response during Tuberculosis but Is Dispensable for Protection and Antigen-Specific IFN-γ Responses if IL-12p70 Is Available1 , 2005, The Journal of Immunology.

[135]  J. Schwartzman,et al.  Interleukin-17/Interleukin-17 Receptor-Mediated Signaling Is Important for Generation of an Optimal Polymorphonuclear Response against Toxoplasma gondii Infection , 2005, Infection and Immunity.

[136]  R. Wu,et al.  IL-17 Markedly Up-Regulates β-Defensin-2 Expression in Human Airway Epithelium via JAK and NF-κB Signaling Pathways1 , 2004, The Journal of Immunology.

[137]  P. Schwarzenberger,et al.  Requirement of interleukin-17A for systemic anti-Candida albicans host defense in mice. , 2004, The Journal of infectious diseases.

[138]  L. Joosten,et al.  Treatment with a neutralizing anti-murine interleukin-17 antibody after the onset of collagen-induced arthritis reduces joint inflammation, cartilage destruction, and bone erosion. , 2004, Arthritis and rheumatism.

[139]  Sarah L. Gaffen,et al.  Functional Cooperation between Interleukin-17 and Tumor Necrosis Factor-α Is Mediated by CCAAT/Enhancer-binding Protein Family Members* , 2004, Journal of Biological Chemistry.

[140]  S. Nakae,et al.  Suppression of Immune Induction of Collagen-Induced Arthritis in IL-17-Deficient Mice 1 , 2003, The Journal of Immunology.

[141]  Ann-Marie Broome,et al.  S100 Protein Subcellular Localization During Epidermal Differentiation and Psoriasis , 2003, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[142]  L. Joosten,et al.  IL-17 Promotes Bone Erosion in Murine Collagen-Induced Arthritis Through Loss of the Receptor Activator of NF-κB Ligand/Osteoprotegerin Balance 1 , 2003, The Journal of Immunology.

[143]  A. Andoh,et al.  Increased expression of interleukin 17 in inflammatory bowel disease , 2003, Gut.

[144]  I. Homma,et al.  Antigen-specific T cell sensitization is impaired in IL-17-deficient mice, causing suppression of allergic cellular and humoral responses. , 2002, Immunity.

[145]  A. Andoh,et al.  IL-17 Selectively Down-Regulates TNF-α-Induced RANTES Gene Expression in Human Colonic Subepithelial Myofibroblasts1 , 2002, The Journal of Immunology.

[146]  P. Schwarzenberger,et al.  Overexpression of IL-17 in the knee joint of collagen type II immunized mice promotes collagen arthritis and aggravates joint destruction , 2002, Inflammation Research.

[147]  S. Deventer,et al.  Contrasting roles of IL‐12p40 and IL‐12p35 in the development of hapten‐induced colitis , 2002, European journal of immunology.

[148]  A. Gurney,et al.  IL‐17: prototype member of an emerging cytokine family , 2002, Journal of leukocyte biology.

[149]  R. Kelley,et al.  IL‐17s adopt a cystine knot fold: structure and activity of a novel cytokine, IL‐17F, and implications for receptor binding , 2001, The EMBO journal.

[150]  J. Shellito,et al.  Requirement of Interleukin 17 Receptor Signaling for Lung Cxc Chemokine and Granulocyte Colony-Stimulating Factor Expression, Neutrophil Recruitment, and Host Defense , 2001, The Journal of experimental medicine.

[151]  Karolina Palucka,et al.  Linking innate and adaptive immunity , 1999, Nature Medicine.

[152]  T. Martin,et al.  IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis. , 1999, The Journal of clinical investigation.

[153]  J. Quach,et al.  Interleukin-17-induced Gene Expression in Articular Chondrocytes Is Associated with Activation of Mitogen-activated Protein Kinases and NF-κB* , 1998, The Journal of Biological Chemistry.

[154]  J. Banchereau,et al.  T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines , 1996, The Journal of experimental medicine.

[155]  M. Seldin,et al.  Herpesvirus saimiri encodes a new cytokine, IL-17, which binds to a novel cytokine receptor. , 1995, Journal of immunology.

[156]  F. Denizot,et al.  CTLA-8, cloned from an activated T cell, bearing AU-rich messenger RNA instability sequences, and homologous to a herpesvirus saimiri gene. , 1993, Journal of immunology.

[157]  R. Panush Autoantibodies against IL-17A, IL-17F, and IL-22 in patients with chronic mucocutaneous candidiasis and autoimmune polyendocrine syndrome type I , 2011 .

[158]  小椋 英樹,et al.  Interleukin-17 promotes autoimmunity by triggering a positive-feedback loop via interleukin-6 induction , 2009 .

[159]  André Reis,et al.  Psoriasis is associated with increased β-defensin genomic copy number , 2008, Nature Genetics.

[160]  浜田 聡 IL-17A produced by γδ T cells plays a critical role in innate immunity against Listeria monocytogenes infection in the liver , 2008 .

[161]  R. Deberardinis,et al.  The biology of cancer: metabolic reprogramming fuels cell growth and proliferation. , 2008, Cell metabolism.

[162]  R. Kastelein,et al.  Understanding the IL-23-IL-17 immune pathway. , 2006, Trends in immunology.

[163]  S. Takemura Lymphoid neogenesis in rheumatoid synovitis , 2003 .

[164]  J. Nelson,et al.  The evolution of vertebrate antigen receptors: a phylogenetic approach. , 2000, Molecular biology and evolution.

[165]  M. Veldhoen,et al.  Interleukin-17-Producing gd T Cells Selectively Expand in Response to Pathogen Products and Environmental Signals , 2022 .