Inositol 1,3,4,5-tetrakisphosphate negatively regulates phosphatidylinositol-3,4,5- trisphosphate signaling in neutrophils.

[1]  S. Schurmans,et al.  Inositol 1,3,4,5-tetrakisphosphate controls proapoptotic Bim gene expression and survival in B cells , 2007, Proceedings of the National Academy of Sciences.

[2]  A. Andreotti,et al.  Positive Regulation of Itk PH Domain Function by Soluble IP4 , 2007, Science.

[3]  H. Hattori,et al.  Tumor suppressor PTEN is a physiologic suppressor of chemoattractant-mediated neutrophil functions. , 2007, Blood.

[4]  M. Cooke,et al.  Production of Ins(1,3,4,5)P4 mediated by the kinase Itpkb inhibits store-operated calcium channels and regulates B cell selection and activation , 2007, Nature Immunology.

[5]  C. Mitchell,et al.  The inositol polyphosphate 5-phosphatases: traffic controllers, waistline watchers and tumour suppressors? , 2007, Biochemical Society symposium.

[6]  H. Hattori,et al.  Deactivation of phosphatidylinositol 3,4,5-trisphosphate/Akt signaling mediates neutrophil spontaneous death , 2006, Proceedings of the National Academy of Sciences.

[7]  L. Cantley,et al.  Ras, PI(3)K and mTOR signalling controls tumour cell growth , 2006, Nature.

[8]  Norihiro Suzuki,et al.  Inositol Hexakisphosphate Kinase-2, a Physiologic Mediator of Cell Death* , 2005, Journal of Biological Chemistry.

[9]  F. Nielsen,et al.  The transcriptional program of terminal granulocytic differentiation. , 2004, Blood.

[10]  Tim Wiltshire,et al.  Inositol (1,4,5) trisphosphate 3 kinase B controls positive selection of T cells and modulates Erk activity. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[11]  S. Shears How versatile are inositol phosphate kinases? , 2004, The Biochemical journal.

[12]  G. Borisy,et al.  Cell Migration: Integrating Signals from Front to Back , 2003, Science.

[13]  S. Schurmans,et al.  Inositol 1,3,4,5-tetrakisphosphate is essential for T lymphocyte development , 2003, Nature Immunology.

[14]  E. Nagata,et al.  Akt as a mediator of cell death , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[15]  E. Nagata,et al.  Inositol Pyrophosphates Mediate Chemotaxis in Dictyostelium via Pleckstrin Homology Domain-PtdIns(3,4,5)P3 Interactions , 2003, Cell.

[16]  L. Missiaen,et al.  The three isoenzymes of human inositol-1,4,5-trisphosphate 3-kinase show specific intracellular localization but comparable Ca2+ responses on transfection in COS-7 cells. , 2003, The Biochemical journal.

[17]  Jingsong Xu,et al.  Divergent Signals and Cytoskeletal Assemblies Regulate Self-Organizing Polarity in Neutrophils , 2003, Cell.

[18]  G. Mayr,et al.  Rat Inositol 1,4,5-Trisphosphate 3-Kinase C Is Enzymatically Specialized for Basal Cellular Inositol Trisphosphate Phosphorylation and Shuttles Actively between Nucleus and Cytoplasm* , 2003, Journal of Biological Chemistry.

[19]  R. Firtel,et al.  Receptor-mediated regulation of PI3Ks confines PI(3,4,5)P3 to the leading edge of chemotaxing cells. , 2003, Molecular biology of the cell.

[20]  M. Lemmon,et al.  Phosphoinositide Recognition Domains , 2003, Traffic.

[21]  K. Hahn,et al.  Spatial and Temporal Analysis of Rac Activation during Live Neutrophil Chemotaxis , 2002, Current Biology.

[22]  P. Devreotes,et al.  Temporal and spatial regulation of chemotaxis. , 2002, Developmental cell.

[23]  Henry R. Bourne,et al.  Cell polarity: A chemical compass , 2002, Nature.

[24]  Klaus Ley,et al.  Chemokines and chemokine receptors in leukocyte trafficking. , 2002, American journal of physiology. Regulatory, integrative and comparative physiology.

[25]  Paul Herzmark,et al.  Lipid products of PI(3)Ks maintain persistent cell polarity and directed motility in neutrophils , 2002, Nature Cell Biology.

[26]  C. Sawyers,et al.  The phosphatidylinositol 3-Kinase–AKT pathway in human cancer , 2002, Nature Reviews Cancer.

[27]  A. Theibert,et al.  Functions of PI 3-kinase in development of the nervous system , 2002, International Journal of Developmental Neuroscience.

[28]  Lewis C Cantley,et al.  The phosphoinositide 3-kinase pathway. , 2002, Science.

[29]  R. Michell Inositol Phosphates: A Remarkably Versatile Enzyme , 2002, Current Biology.

[30]  P. Hawkins,et al.  Roles of PI3Ks in leukocyte chemotaxis and phagocytosis. , 2002, Current opinion in cell biology.

[31]  D. Roymans,et al.  Cloning and expression of a full-length cDNA encoding human inositol 1,4,5-trisphosphate 3-kinase B. , 2002, Biochemical and biophysical research communications.

[32]  P. Majerus,et al.  Phosphoinositide-specific Inositol Polyphosphate 5-Phosphatase IV Inhibits Akt/Protein Kinase B Phosphorylation and Leads to Apoptotic Cell Death* , 2002, The Journal of Biological Chemistry.

[33]  E. Nagata,et al.  Inositol pyrophosphates are required for DNA hyperrecombination in protein kinase c1 mutant yeast. , 2002, Biochemistry.

[34]  E. Nagata,et al.  GRAB: A Physiologic Guanine Nucleotide Exchange Factor for Rab3a, which Interacts with Inositol Hexakisphosphate Kinase , 2001, Neuron.

[35]  D. Kalvakolanu,et al.  Inositol Hexakisphosphate Kinase 2 Mediates Growth Suppressive and Apoptotic Effects of Interferon-β in Ovarian Carcinoma Cells* , 2001, The Journal of Biological Chemistry.

[36]  Richard A. Firtel,et al.  Role of Phosphatidylinositol 3′ Kinase and a Downstream Pleckstrin Homology Domain–Containing Protein in Controlling Chemotaxis inDictyostelium , 2001, The Journal of cell biology.

[37]  M. Schell,et al.  Back in the water: the return of the inositol phosphates , 2001, Nature Reviews Molecular Cell Biology.

[38]  D. Cantrell Phosphoinositide 3-kinase signalling pathways. , 2001, Journal of cell science.

[39]  S. Snyder,et al.  The Inositol Hexakisphosphate Kinase Family , 2000, Journal of Biological Chemistry.

[40]  M. Lemmon,et al.  Structural basis for discrimination of 3-phosphoinositides by pleckstrin homology domains. , 2000, Molecular cell.

[41]  S. Lietzke,et al.  Structural basis of 3-phosphoinositide recognition by pleckstrin homology domains. , 2000, Molecular cell.

[42]  R. Sessions,et al.  Molecular modelling and site-directed mutagenesis of the inositol 1,3,4,5-tetrakisphosphate-binding pleckstrin homology domain from the Ras GTPase-activating protein GAP1IP4BP. , 2000, The Biochemical journal.

[43]  M. Berridge,et al.  Inositol 1,4,5-trisphosphate-induced Ca2+ release is inhibited by mitochondrial depolarization. , 2000, The Biochemical journal.

[44]  G. Neubauer,et al.  Regulation of intracellular calcium by a signalling complex of IRAG, IP3 receptor and cGMP kinase Iβ , 2000, Nature.

[45]  Pier Paolo Pandolfi,et al.  The Multiple Roles of PTEN in Tumor Suppression , 2000, Cell.

[46]  Dianqing Wu,et al.  Roles of PLC-β2 and -β3 and PI3Kγ in Chemoattractant-Mediated Signal Transduction , 2000 .

[47]  J W Sedat,et al.  Polarization of chemoattractant receptor signaling during neutrophil chemotaxis. , 2000, Science.

[48]  C. Brearley,et al.  PiUS (Pi uptake stimulator) is an inositol hexakisphosphate kinase , 1999, FEBS letters.

[49]  C. Parent,et al.  A cell's sense of direction. , 1999, Science.

[50]  J. Dixon,et al.  PTEN: a tumour suppressor that functions as a phospholipid phosphatase. , 1999, Trends in cell biology.

[51]  M. Wigler,et al.  The lipid phosphatase activity of PTEN is critical for its tumor supressor function. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[52]  José Luis de la Pompa,et al.  Negative Regulation of PKB/Akt-Dependent Cell Survival by the Tumor Suppressor PTEN , 1998, Cell.

[53]  D. Storm,et al.  Enhanced hippocampal CA1 LTP but normal spatial learning in inositol 1,4,5-trisphosphate 3-kinase(A)-deficient mice. , 1998, Learning & memory.

[54]  R. Tsien,et al.  D-myo-Inositol 1,4,5,6-tetrakisphosphate produced in human intestinal epithelial cells in response to Salmonella invasion inhibits phosphoinositide 3-kinase signaling pathways. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[55]  M. Simon,et al.  Roles of phospholipase C beta2 in chemoattractant-elicited responses. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[56]  C. Turck,et al.  Identification and Cloning of Centaurin-α , 1996, The Journal of Biological Chemistry.

[57]  G. Bokoch Chemoattractant signaling and leukocyte activation. , 1995, Blood.

[58]  Peter J. Cullen,et al.  Identification of a specific lns(l,3,4,5)P4-binding protein as a member of the GAP1 family , 1995, Nature.

[59]  C. D’Santos,et al.  Tissue- and cell-specific expression of Ins(1,4,5)P3 3-kinase isoenzymes. , 1995, The Biochemical journal.

[60]  R. Irvine Inositide evolution: what can it tell us about functions? , 1995, Biochemical Society transactions.

[61]  P. V. van Haastert,et al.  Phosphorylation of inositol 1,4,5-trisphosphate analogues by 3-kinase and dephosphorylation of inositol 1,3,4,5-tetrakisphosphate analogues by 5-phosphatase. , 1994, European journal of biochemistry.

[62]  J. Stuart,et al.  The intracellular distribution of inositol polyphosphates in HL60 promyeloid cells. , 1994, The Biochemical journal.

[63]  M. Berridge Inositol trisphosphate and calcium signalling , 1993, Nature.

[64]  P. Newell,et al.  Accumulation of [3H]-inositol into inositol polyphosphates during development of Dictyostelium. , 1991, Biochemical and biophysical research communications.

[65]  C. Bunce,et al.  Changes in the levels of inositol lipids and phosphates during the differentiation of HL60 promyelocytic cells towards neutrophils or monocytes , 1991, Proceedings of the Royal Society of London. Series B: Biological Sciences.

[66]  J. Dumont,et al.  Molecular cloning and expression of a new putative inositol 1,4,5-trisphosphate 3-kinase isoenzyme. , 1991, The Biochemical journal.

[67]  D. Fruman,et al.  Changes in inositol 1,4,5-trisphosphate mass in agonist-stimulated human neutrophils , 1991, Agents and Actions.

[68]  S. Y. Lee,et al.  Molecular cloning and expression of a complementary DNA for inositol 1,4,5-trisphosphate 3-kinase. , 1990, Science.

[69]  S. Zigmond Chemotactic response of neutrophils. , 1989, American journal of respiratory cell and molecular biology.

[70]  P. Bradford,et al.  Quantitative changes in inositol 1,4,5-trisphosphate in chemoattractant-stimulated neutrophils. , 1986, The Journal of biological chemistry.

[71]  P. Finan,et al.  PI(3)Kγ has an important context-dependent role in neutrophil chemokinesis , 2007, Nature Cell Biology.