Adult siRNA-induced knockdown of mGlu7 receptors reduces anxiety in the mouse

[1]  M. Popoli,et al.  The Action of Antidepressants on the Glutamate System: Regulation of Glutamate Release and Glutamate Receptors , 2013, Biological Psychiatry.

[2]  J. Cryan,et al.  The effects of mGlu7 receptor modulation in behavioural models sensitive to antidepressant action in two mouse strains , 2013, Behavioural pharmacology.

[3]  T. Salt,et al.  ADX71743, a Potent and Selective Negative Allosteric Modulator of Metabotropic Glutamate Receptor 7: In Vitro and In Vivo Characterization , 2013, The Journal of Pharmacology and Experimental Therapeutics.

[4]  Andrzej Pilc,et al.  A selective mGlu7 receptor antagonist MMPIP reversed antidepressant-like effects of AMN082 in rats , 2013, Behavioural Brain Research.

[5]  T. Dinan,et al.  Hippocampal group III mGlu receptor mRNA levels are not altered in specific mouse models of stress, depression and antidepressant action , 2013, Pharmacology Biochemistry and Behavior.

[6]  W. Klimesch.  Alpha-band oscillations, attention, and controlled access to stored information , 2012, Trends in Cognitive Sciences.

[7]  F. Ferraguti,et al.  Histone deacetylase inhibitors, glutamatergic drugs and deep brain stimulation rescue resistance to fear extinction in a genetic mouse model , 2012, BMC Pharmacology and Toxicology.

[8]  J. Uslaner,et al.  The mGluR7 allosteric agonist AMN082 produces antidepressant-like effects by modulating glutamatergic signaling , 2012, Pharmacology Biochemistry and Behavior.

[9]  Zhen Yan,et al.  Regulation of N-Methyl-d-aspartic Acid (NMDA) Receptors by Metabotropic Glutamate Receptor 7*♦ , 2012, The Journal of Biological Chemistry.

[10]  J. Cryan,et al.  The age of anxiety: role of animal models of anxiolytic action in drug discovery , 2011, British journal of pharmacology.

[11]  J. Dwyer,et al.  The Metabotropic Glutamate Receptor 7 Allosteric Modulator AMN082: A Monoaminergic Agent in Disguise? , 2011, Journal of Pharmacology and Experimental Therapeutics.

[12]  T. Dinan,et al.  Comparison of hippocampal metabotropic glutamate receptor 7 (mGlu7) mRNA levels in two animal models of depression , 2010, Neuroscience Letters.

[13]  Andrzej Pilc,et al.  The Antidepressant-Like Action of Metabotropic Glutamate 7 Receptor Agonist N,N′-Bis(Diphenylmethyl)-1,2-Ethanediamine (AMN082) Is Serotonin-Dependent , 2010, Journal of Pharmacology and Experimental Therapeutics.

[14]  J. Cryan,et al.  Metabotropic glutamate receptor 7: at the interface of cognition and emotion. , 2010, European journal of pharmacology.

[15]  T. Dinan,et al.  Leptin-deficient mice retain normal appetitive spatial learning yet exhibit marked increases in anxiety-related behaviours , 2010, Psychopharmacology.

[16]  M. Fendt,et al.  The effect of mGlu8 deficiency in animal models of psychiatric diseases , 2010, Genes, brain, and behavior.

[17]  J. Cryan,et al.  G Protein-Coupled Receptors: Role of metabotropic glutamate receptors in CNS disorders , 2010 .

[18]  M. Fendt,et al.  Fear-reducing effects of intra-amygdala neuropeptide Y infusion in animal models of conditioned fear: an NPY Y1 receptor independent effect , 2009, Psychopharmacology.

[19]  P. Kelly,et al.  Increased exploratory activity of APP23 mice in a novel environment is reversed by siRNA , 2008, Brain Research.

[20]  M. Fendt,et al.  mGluR7 facilitates extinction of aversive memories and controls amygdala plasticity , 2008, Molecular Psychiatry.

[21]  J. Cryan,et al.  Selective activation of metabotropic G-protein-coupled glutamate 7 receptor elicits anxiolytic-like effects in mice by modulating GABAergic neurotransmission , 2008, Behavioural pharmacology.

[22]  P. Flor,et al.  Activation of the mGlu7 receptor elicits antidepressant-like effects in mice , 2007, Psychopharmacology.

[23]  K. Roche,et al.  mGluR7 undergoes rapid internalization in response to activation by the allosteric agonist AMN082 , 2007, Neuropharmacology.

[24]  J. Cryan,et al.  Feeling Strained? Influence of Genetic Background on Depression-Related Behavior in Mice: A Review , 2007, Behavior genetics.

[25]  Francesco Ferraguti,et al.  Metabotropic glutamate receptors , 2006, Cell and Tissue Research.

[26]  R. D'Hooge,et al.  Concomitant Deficits in Working Memory and Fear Extinction Are Functionally Dissociated from Reduced Anxiety in Metabotropic Glutamate Receptor 7-Deficient Mice , 2006, The Journal of Neuroscience.

[27]  J. Cryan,et al.  Metabotropic Glutamate Receptor Subtype 7 Ablation Causes Dysregulation of the HPA Axis and Increases Hippocampal BDNF Protein Levels: Implications for Stress-Related Psychiatric Disorders , 2006, Neuropsychopharmacology.

[28]  J. A. Boer,et al.  Evidence-based guidelines for the pharmacological treatment of anxiety disorders: recommendations from the British Association for Psychopharmacology , 2005, Journal of psychopharmacology.

[29]  Dieter Huesken,et al.  Design of a genome-wide siRNA library using an artificial neural network , 2005, Nature Biotechnology.

[30]  F. Natt,et al.  siRNA-mediated knockdown of the serotonin transporter in the adult mouse brain , 2005, Molecular Psychiatry.

[31]  J. Olesen,et al.  Cost of disorders of the brain in Europe , 2005, European journal of neurology.

[32]  C. Swanson,et al.  Metabotropic glutamate receptors as novel targets for anxiety and stress disorders , 2005, Nature Reviews Drug Discovery.

[33]  D. Nutt.  Overview of Diagnosis and Drug Treatments of Anxiety Disorders , 2005, CNS Spectrums.

[34]  M. Geyer,et al.  Anxiogenic treatments do not increase fear-potentiated startle in mice , 2005, Biological Psychiatry.

[35]  F. Natt,et al.  siRNA-mediated knockdown of the serotonin transporter in the adult mouse brain , 2005, Molecular Psychiatry.

[36]  F. Natt,et al.  Neurochemical and behavioral consequences of widespread gene knockdown in the adult mouse brain by using nonviral RNA interference. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[37]  P. Kelly,et al.  Behavioral Characterization of the Novel GABAB Receptor-Positive Modulator GS39783 (N,N′-Dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine): Anxiolytic-Like Activity without Side Effects Associated with Baclofen or Benzodiazepines , 2004, Journal of Pharmacology and Experimental Therapeutics.

[38]  J. Cryan,et al.  Genetic and Pharmacological Evidence of a Role for GABAB Receptors in the Modulation of Anxiety- and Antidepressant-Like Behavior , 2004, Neuropsychopharmacology.

[39]  D. Hoyer,et al.  Withdrawal from chronic amphetamine induces Depressive-Like behavioral effects in rodents , 2003, Biological Psychiatry.

[40]  P. Kelly,et al.  Antidepressant and anxiolytic‐like effects in mice lacking the group III metabotropic glutamate receptor mGluR7 , 2003, The European journal of neuroscience.

[41]  M. Hascöet,et al.  The mouse light/dark box test. , 2003, European journal of pharmacology.

[42]  R. Gerlai.  Afraid of complications in gene targeting? Anxiety plays a role! , 2002, Trends in Neurosciences.

[43]  G. Collingridge,et al.  Increased Seizure Susceptibility in Mice Lacking Metabotropic Glutamate Receptor 7 , 2001, The Journal of Neuroscience.

[44]  G. Griebel,et al.  Measuring normal and pathological anxiety-like behaviour in mice: a review , 2001, Behavioural Brain Research.

[45]  C. Lüscher,et al.  Epilepsy, Hyperalgesia, Impaired Memory, and Loss of Pre- and Postsynaptic GABAB Responses in Mice Lacking GABAB(1) , 2001, Neuron.

[46]  Neil Upton,et al.  Epileptogenesis and Enhanced Prepulse Inhibition in GABAB1-Deficient Mice , 2001, Molecular and Cellular Neuroscience.

[47]  J. Crawley.  Behavioral phenotyping of transgenic and knockout mice: experimental design and evaluation of general health, sensory functions, motor abilities, and specific behavioral tests 1 Published on the World Wide Web on 2 December 1998. 1 , 1999, Brain Research.

[48]  S. Nakanishi,et al.  Metabotropic Glutamate Receptor Subtype 7 Ablation Causes Deficit in Fear Response and Conditioned Taste Aversion , 1999, The Journal of Neuroscience.

[49]  George Paxinos,et al.  The Mouse Brain in Stereotaxic Coordinates , 2001 .

[50]  J. Turner,et al.  Fear-potentiated startle in two strains of inbred mice. , 1997, Behavioral neuroscience.

[51]  S. Heinemann,et al.  Spatial distribution of kainate receptor subunit mRNA in the mouse basal ganglia and ventral mesencephalon , 1997, The Journal of comparative neurology.

[52]  T. Knöpfel,et al.  A Novel Splice Variant of a Metabotropic Glutamate Receptor, Human mGluR7b , 1997, Neuropharmacology.