Prevalence of six types of human papillomavirus in inverted papilloma and papillary transitional cell carcinoma of the bladder: an evaluation by polymerase chain reaction.

AIMS: To study the prevalence of high risk oncogenic human papillomaviruses (HPV) in inverted papilloma and papillary transitional cell carcinoma of the bladder. METHODS: Ten cases of inverted papilloma and 20 cases of papillary transitional cell carcinoma of the bladder from Chinese patients in Hong Kong were examined for the presence of HPV type 6, 11, 16, 18, 31, and 33 genomes using the polymerase chain reaction and HPV type specific primer probe combinations on paraffin wax embedded biopsy specimens. RESULTS: Of the 10 cases of inverted papilloma, cases 1 and 6 showed the presence of HPV types 16 and 18, respectively. Six of the 20 papillary transitional cell carcinomas were positive for HPV type 18. The other HPV types were not detected. CONCLUSIONS: HPV type 18 was found in 60% and 30% of cases of inverted papilloma and papillary transitional cell carcinoma of the bladder, respectively. These tumours were rarely associated with HPV types 6, 11, 16, 31, and 33. The role of HPV type 18 in oncogenesis of inverted papilloma and transitional cell carcinoma of the bladder requires further studies.

[1]  G. Srivastava,et al.  Accumulation of p53 protein in inverted transitional cell papilloma of the urinary bladder , 1996, Clinical molecular pathology.

[2]  R. Zappatore,et al.  p53 OVEREXPRESSION AND HUMAN PAPILLOMAVIRUS INFECTION IN TRANSITIONAL CELL CARCINOMA OF THE URINARY BLADDER: CORRELATION WITH HISTOLOGICAL PARAMETERS , 1996, The Journal of pathology.

[3]  A. López-Beltran,et al.  Transitional cell carcinoma of the bladder: low incidence of human papillomavirus DNA detected by the polymerase chain reaction and in situ hybridization , 1995, Histopathology.

[4]  Y. Soini,et al.  Human papillomavirus DNA and abnormal p53 expression in carcinoma of the urinary bladder , 1995, APMIS : acta pathologica, microbiologica, et immunologica Scandinavica.

[5]  G. Srivastava,et al.  Prevalence of human papillomavirus types 16 and 18 in penile carcinoma: a study of 41 cases using PCR. , 1994, Journal of clinical pathology.

[6]  M. Wu,et al.  Prevalence of human papillomaviruses 16 and 18 in transitional cell carcinoma of bladder. , 1993, Chinese medical journal.

[7]  H. Naiki,et al.  High frequency of human papillomavirus infection in carcinoma of the urinary bladder , 1992, Cancer.

[8]  Bert Vogelstein,et al.  p53 function and dysfunction , 1992, Cell.

[9]  M. Schoenberg,et al.  Human papillomavirus associated with bladder cancer. , 1992, Urology.

[10]  B. Vogelstein,et al.  p53 mutations in human cancers. , 1991, Science.

[11]  D. Wilson,et al.  Detection of human papillomavirus DNA in cancer of the urinary bladder by in situ hybridisation. , 1991, British journal of urology.

[12]  J. Walboomers,et al.  Difference in prevalence of human papillomavirus genotypes in cytomorphologically normal cervical smears is associated with a history of cervical intraepithelial neoplasia , 1991, International journal of cancer.

[13]  K. Vousden,et al.  RELATION BETWEEN INFECTION WITH A SUBTYPE OF HPV16 AND CERVICAL NEOPLASIA , 1989, The Lancet.

[14]  C. Woodman,et al.  The polymerase chain reaction: a new epidemiological tool for investigating cervical human papillomavirus infection. , 1989, BMJ.

[15]  K. Mullis,et al.  Enzymatic amplification of beta-globin genomic sequences and restriction site analysis for diagnosis of sickle cell anemia. , 1985, Science.

[16]  B. Lazarevic,et al.  Inverted papilloma and papillary transitional cell carcinoma of urinary bladder. Report of four cases of inverted papilloma, one showing papillary malignant transformation and review of the literature , 1978, Cancer.

[17]  M. Stanley,et al.  HPV and p 53 in cervical cancer , 2022 .