Stage I‐II follicular lymphoma: Treatment results for 76 patients

Clinical features and treatment results are analyzed for 76 patients with Stage I‐II follicular lymphoma seen between 1974 and 1981. During this period, 66% of the patients received involved‐field radiotherapy (XRT) alone, and 34% received chemotherapy with or without XRT. At 5 years, the overall survival was 67%, the cause‐specific survival was 73%, and the relapse‐free survival (RFS) was 48%, with no relapses to date among nine patients followed beyond 60 months. Adverse prognostic features for survival included extranodal disease and elevated serum lactate dehydrogenase. For RFS, adverse features included extranodal disease and bulky abdominal disease. The RFS was significantly better for patients receiving chemotherapy with or without XRT than for XRT alone (64% versus 37% at 5 years, P = 0.02), despite a higher frequency of adverse prognostic features in the chemotherapy‐treated group. About 50% of Stage I‐II follicular lymphoma patients may be curable, and the inclusion of chemotherapy in the initial treatment may increase the potentially curable fraction.

[1]  G. Pinkus,et al.  Circulating monoclonal B lymphocytes in non-Hodgkin's lymphoma. , 1984, The New England journal of medicine.

[2]  S. Horning,et al.  The natural history of initially untreated low-grade non-Hodgkin's lymphomas. , 1984, The New England journal of medicine.

[3]  T. Colby,et al.  The role of radiation therapy in the management of stage III follicular lymphomas. , 1984, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[4]  H. Kantarjian,et al.  Follicular large cell lymphoma: analysis and prognostic factors in 62 patients. , 1984, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[5]  M. Gospodarowicz,et al.  Prognostic factors in nodular lymphomas: a multivariate analysis based on the Princess Margaret Hospital experience. , 1984, International journal of radiation oncology, biology, physics.

[6]  T. Colby,et al.  Analysis of non‐Hodgkin's lymphomas with nodular and favorable histologies, stages I and II , 1983, Cancer.

[7]  R. Hartsock,et al.  Improved complete remission rates and survival for patients with large cell lymphoma treated with chemoimmunotherapy: A southwest oncology group study , 1983, Cancer.

[8]  S. Rosenberg,et al.  The treatment of advanced stage favorable histology non-Hodgkin's lymphoma: a preliminary report of a randomized trial comparing single agent chemotherapy, combination chemotherapy, and whole body irradiation. , 1981, Blood.

[9]  L. Fuller,et al.  Laparotomy findings in lymphangiogram‐staged I and II non‐Hodgkin's lymphomas , 1980, Cancer.

[10]  E. Frenkel,et al.  Detection of tumor cells in the peripheral blood of nonleukemic patients with B-cell lymphoma: analysis of "clonal excess". , 1980, Blood.

[11]  G. Bonadonna,et al.  Improved five year survival after combined radiotherapy-chemotherapy for stage I-II non-Hodgkin's lymphoma. , 1980, International journal of radiation oncology, biology, physics.

[12]  L. Fuller,et al.  Laparotomy staged I and II non‐Hodgkin's lymphomas preliminary results of radiotherapy and adjunctive chemotherapy , 1980, Cancer.

[13]  F. Cabanillas,et al.  Nodular malignant lymphomas. Factors affecting complete response rate and survival , 1979, Cancer.

[14]  T. Landberg,et al.  CVP—Remission—maintenance in stage I or II non‐Hodgkin's lymphomas Preliminary results of a randomized study , 1979, Cancer.

[15]  R. DeLellis,et al.  Nodular non‐Hodgkin's lymphoma (NHL): Factors influencing prognosis and indications for aggressive treatment , 1979, Cancer.

[16]  L. Prosnitz,et al.  Results of radiotherapy in control of stage I and II non‐Hodgkin's lymphoma , 1979, Cancer.

[17]  S. Rosenberg,et al.  No initial therapy for stage III and IV non-Hodgkin's lymphomas of favorable histologic types. , 1979, Annals of internal medicine.

[18]  J. Kinzie,et al.  Non‐hodgkin's lymphoma, poorly differentiated lymphocytic and mixed cell types. Results of sequential staging procedures, response to therapy, and survival of 100 patients , 1978, Cancer.

[19]  V. Devita,et al.  Sequential Nonsurgical and Surgical Staging of Non-Hodgkin's Lymphoma , 1976 .

[20]  R. Qazi,et al.  The natural history of nodular lymphoma , 1976, Cancer.

[21]  Z. Fuks,et al.  Non‐hodgkin's lymphomas iv. clinicopathologic correlation in 405 cases , 1973, Cancer.

[22]  M Tubiana,et al.  Report of the Committee on Hodgkin's Disease Staging Classification. , 1971, Cancer research.

[23]  E. Gehan.  A GENERALIZED WILCOXON TEST FOR COMPARING ARBITRARILY SINGLY-CENSORED SAMPLES. , 1965, Biometrika.

[24]  E. Kaplan,et al.  Nonparametric Estimation from Incomplete Observations , 1958 .