Artemisinin production and precursor ratio in full grown Artemisia annua L. plants subjected to external stress

[1]  A. Kjær,et al.  Effect of external stress on density and size of glandular trichomes in full-grown Artemisia annua, the source of anti-malarial artemisinin , 2012, AoB PLANTS.

[2]  S. Ćavar,et al.  Chemical composition and antioxidant and antimicrobial activity of essential oil of Artemisia annua L. from Bosnia , 2012 .

[3]  P. Brodelius,et al.  Trichome isolation with and without fixation using laser microdissection and pressure catapulting followed by RNA amplification: expression of genes of terpene metabolism in apical and sub-apical trichome cells of Artemisia annua L. , 2012, Plant science : an international journal of experimental plant biology.

[4]  A. Shukla,et al.  UV-B and UV-C pre-treatments induce physiological changes and artemisinin biosynthesis in Artemisia annua L. - an antimalarial plant. , 2011, Journal of photochemistry and photobiology. B, Biology.

[5]  T. Efferth,et al.  Cytotoxic activity of secondary metabolites derived from Artemisia annua L. towards cancer cells in comparison to its designated active constituent artemisinin. , 2011, Phytomedicine : international journal of phytotherapy and phytopharmacology.

[6]  P. Tudzynski,et al.  Reactive oxygen species in phytopathogenic fungi: signaling, development, and disease. , 2011, Annual review of phytopathology.

[7]  R. Sirdeshmukh,et al.  Transcriptomic and Proteomic Profile of Aspergillus fumigatus on Exposure to Artemisinin , 2011, Mycopathologia.

[8]  Moinuddin,et al.  Enhancing the growth, photosynthetic capacity and artemisinin content in Artemisia annua L. by irradiated sodium alginate , 2011 .

[9]  P. Arsenault,et al.  Trichomes + roots + ROS = artemisinin: regulating artemisinin biosynthesis in Artemisia annua L. , 2011, In Vitro Cellular & Developmental Biology - Plant.

[10]  Yanming Zhu,et al.  Chemotype-dependent metabolic response to methyl jasmonate elicitation in Artemisia annua. , 2011, Planta medica.

[11]  K. Tang,et al.  Effect of wounding on gene expression involved in artemisinin biosynthesis and artemisinin production in Artemisia annua , 2010, Russian Journal of Plant Physiology.

[12]  Geoffrey D. Brown.  The Biosynthesis of Artemisinin (Qinghaosu) and the Phytochemistry of Artemisia annua L. (Qinghao) , 2010, Molecules.

[13]  P. Arsenault,et al.  Reproductive Development Modulates Gene Expression and Metabolite Levels with Possible Feedback Inhibition of Artemisinin in Artemisia annua1[C][W][OA] , 2010, Plant Physiology.

[14]  Chunzhao Liu,et al.  DMSO triggers the generation of ROS leading to an increase in artemisinin and dihydroartemisinic acid in Artemisia annua shoot cultures , 2010, Plant Cell Reports.

[15]  Yi Li,et al.  The Genetic Map of Artemisia annua L. Identifies Loci Affecting Yield of the Antimalarial Drug Artemisinin , 2010, Science.

[16]  Devanand L. Luthria,et al.  Drying affects artemisinin, dihydroartemisinic acid, artemisinic acid, and the antioxidant capacity of Artemisia annua L. leaves. , 2010, Journal of agricultural and food chemistry.

[17]  Juan Li,et al.  Supporting Information to : Isolation and Identification of Novel Genes Involved in Artemisinin Production from Flowers of Artemisia Annua Using Suppression Subtractive Hybridization and Metabolite Analysis , 2009 .

[18]  Hong Wang,et al.  Salicylic acid activates artemisinin biosynthesis in Artemisia annua L. , 2009, Plant Cell Reports.

[19]  M. Olsson,et al.  Localization of enzymes of artemisinin biosynthesis to the apical cells of glandular secretory trichomes of Artemisia annua L. , 2009, Phytochemistry.

[20]  G. Marconi,et al.  Distribution of artemisinin and bioactive flavonoids from Artemisia annua L. during plant growth , 2008 .

[21]  Chenfei Ma,et al.  Metabolic fingerprinting investigation of Artemisia annua L. in different stages of development by gas chromatography and gas chromatography-mass spectrometry. , 2008, Journal of chromatography. A.

[22]  H. Bouwmeester,et al.  Artemisinin and sesquiterpene precursors in dead and green leaves of Artemisia annua L. crops. , 2007, Planta medica.

[23]  R. Kapoor,et al.  Effects of arbuscular mycorrhiza and phosphorus application on artemisinin concentration in Artemisia annua L. , 2007, Mycorrhiza.

[24]  Y. Shoyama,et al.  Improvement of artemisinin production by chitosan in hairy root cultures of Artemisia annua L. , 2007, Biotechnology Letters.

[25]  H. Ye,et al.  Effect of Development Stage on the Artemisinin Content and the Sequence Characterized Amplified Region (SCAR) Marker of High-Artemisinin Yielding Strains of Artemisia annua L. , 2006 .

[26]  Timothy S. Ham,et al.  Production of the antimalarial drug precursor artemisinic acid in engineered yeast , 2006, Nature.

[27]  H. Bouwmeester,et al.  Trichome dynamics and artemisinin accumulation during development and senescence of Artemisia annua leaves. , 2006, Planta medica.

[28]  R. Tan,et al.  Improved artemisinin accumulation in hairy root cultures of Artemisia annua by (22S, 23S)-homobrassinolide , 2002, Biotechnology Letters.

[29]  R. Tan,et al.  Terpenoids and flavonoids from Artemisia species. , 2000, Planta medica.

[30]  W. Quax,et al.  Seasonal Variation of Artemisinin and its Biosynthetic Precursors in Plants of Artemisia annua of Different Geographical Origin: Proof for the Existence of Chemotypes , 2000, Planta medica.

[31]  H. Bouwmeester,et al.  Amorpha-4,11-diene synthase catalyses the first probable step in artemisinin biosynthesis. , 1999, Phytochemistry.

[32]  Pras,et al.  Isolation and identification of dihydroartemisinic acid hydroperoxide from artemisia annua: A novel biosynthetic precursor of artemisinin , 1999, Journal of natural products.

[33]  F. Ouyang,et al.  Improvement of artemisinin accumulation in hairy root cultures of Artemisia annua L by fungal elicitor , 1999 .

[34]  J. Janick.  Floral Morphology of Artemisia annua with Special Reference to Trichomes , 1995, International Journal of Plant Sciences.

[35]  S. Duke.  Glandular Trichomes-A Focal Point of Chemical and Structural Interactions , 1994, International Journal of Plant Sciences.

[36]  S. Duke,et al.  Development and Fine Structure of the Glandular Trichomes of Artemisia annua L. , 1993, International Journal of Plant Sciences.

[37]  R. Liersch,et al.  Formation of Artemisinin in Artemisia annua During One Vegetation Period*,1 , 1986, Planta medica.

[38]  R Core Team,et al.  R: A language and environment for statistical computing. , 2014 .

[39]  D. Inzé,et al.  Dissection of the phytohormonal regulation of trichome formation and biosynthesis of the antimalarial compound artemisinin in Artemisia annua plants. , 2011, The New phytologist.

[40]  Hong Wang,et al.  Foliar application of chitosan activates artemisinin biosynthesis in Artemisia annua L. , 2011 .

[41]  Patrick S Covello.  Making artemisinin. , 2008, Phytochemistry.

[42]  H. Bouwmeester,et al.  Identification of intermediates and enzymes involved in the early steps of artemisinin biosynthesis in Artemisia annua. , 2005, Planta medica.