Ending hunger and achieving food security - one of the UN sustainable development goals - is a major global challenge. To inform the policy debate, quantified global scenarios and projections are used to assess long-term future global food security under a range of socio-economic and climate change scenarios. However, due to differences in model design and scenario assumptions, there is uncertainty about the range of food security projections and outcomes. We conducted a systematic literature review and meta-analysis to assess the range of future global food security projections to 2050. We reviewed 57 global food security projection and quantitative scenario studies that have been published over the last two decades and discussed the methodology, underlying drivers, indicators and projections. We harvested quantitative information from 26 studies to compare future trends of the two most used global food security indicators: per capita food demand (593 projections) and population at risk of hunger (358 projections). We found that across five representative scenarios that span divergent but plausible socio-economic futures total global food demand is expected to increase by +35% to +56% between 2010 and 2050, while population at risk of hunger is expected to change by -91% to +8% over the same period. If climate change is taken into account the range changes slightly (+30% to +62% for total food demand and -91% to +30% for population at risk of hunger) but overall we do not find statistical support for differences in projections with and without climate change. Finally, our review suggests that current modeling approaches can be improved by better incorporating several options that have been proposed to tackle global food security, in particular aquaculture and ‘future foods’, and expand the number of indicators to better cover the multiple dimensions of food security. The results of our review can be used to benchmark new global food security projections and quantitative scenario studies and inform policy analysis and the public debate on the future of food.