Classification of delusions in Alzheimer's disease and their neural correlates

Background:  Previous findings on neural correlates of delusion in Alzheimer's disease (AD) have been inconsistent because of methodological issues, such as treating multiple delusions as a single entity. In this retrospective study, we classified AD delusions and investigated their neural correlates by using single‐photon emission computed tomography data.

[1]  H. Matsuda,et al.  Comparative SPECT Study of Stroke Using Tc-99m ECD, I-123 IMP, and Tc-99m HMPAO , 1993, Clinical nuclear medicine.

[2]  E. Rubin.  Delusions as part of Alzheimer's disease : Psychosis in neurologic diseases , 1992 .

[3]  E. H. Burrows,et al.  Focal retrograde amnesia following bilateral temporal lobe pathology. A neuropsychological and magnetic resonance study. , 1992, Brain : a journal of neurology.

[4]  M. Ikeda,et al.  Delusions of Japanese patients with Alzheimer's disease , 2003, International journal of geriatric psychiatry.

[5]  P. Benson,et al.  Towards a functional neuroanatomy of self processing: effects of faces and words. , 2000, Brain research. Cognitive brain research.

[6]  Karl Magnus Petersson,et al.  The role of precuneus and left inferior frontal cortex during source memory episodic retrieval , 2005, NeuroImage.

[7]  J. Cummings,et al.  Psychometric and SPECT studies in alzheimer’s disease with and without delusions , 1995 .

[8]  K. Kotrla,et al.  SPECT findings on psychosis in Alzheimer's disease. , 1995, The American journal of psychiatry.

[9]  C. Pedone,et al.  Antipsychotics for the Treatment of Behavioral and Psychological Symptoms of Dementia (BPSD) , 2008, Current neuropharmacology.

[10]  Jae-On Kim,et al.  Factor Analysis: Statistical Methods and Practical Issues , 1978 .

[11]  A. Burns,et al.  The delusional misidentification syndromes in patients with and without evidence of organic cerebral disorder: A structured review of case reports , 1993, Biological Psychiatry.

[12]  Arthur W. Toga,et al.  A Probabilistic Atlas of the Human Brain: Theory and Rationale for Its Development The International Consortium for Brain Mapping (ICBM) , 1995, NeuroImage.

[13]  R. Leiguarda,et al.  A SPECT study of delusions in Alzheimer's disease , 1994, Neurology.

[14]  S. Tsai,et al.  Phantom boarder symptom in dementia , 2003, International journal of geriatric psychiatry.

[15]  H. Arai,et al.  Risk factors for delusion of theft in patients with Alzheimer's disease showing mild Dementia in Japan , 2009, Aging & mental health.

[16]  S. Awata,et al.  Behavioral and psychological symptoms of dementia characteristic of mild Alzheimer patients , 2005, Psychiatry and clinical neurosciences.

[17]  Desmond J Oathes,et al.  Worry facilitates corticospinal motor response to transcranial magnetic stimulation , 2008, Depression and anxiety.

[18]  P. Gloor,et al.  The role of the limbic system in experiential phenomena of temporal lobe epilepsy , 1982, Annals of neurology.

[19]  W. Hauser,et al.  Predictors of disease course in patients with probable Alzheimer's disease , 1987, Neurology.

[20]  Albert Gjedde,et al.  Subcortical elevation of metabolism in Parkinson's disease — A critical reappraisal in the context of global mean normalization , 2009, NeuroImage.

[21]  G. Wilcock,et al.  Classification of psychotic symptoms in dementia sufferers , 1995, Acta psychiatrica Scandinavica.

[22]  T. Feinberg,et al.  Misidentification-reduplication and the right hemisphere. , 1989 .

[23]  A. Kertesz,et al.  The Prevalence of Misidentification Syndromes in Neurodegenerative Diseases , 2008, Alzheimer disease and associated disorders.

[24]  Gene E. Alexander,et al.  Abnormal brain glucose metabolism in the delusional misidentification syndromes: A positron emission tomography study in Alzheimer disease , 1995, Biological Psychiatry.

[25]  B. Lipkin.  Capgras Syndrome Heralding the Development of Dementia , 1988, British Journal of Psychiatry.

[26]  Tim D. Fryer,et al.  Declarative memory impairments in Alzheimer's disease and semantic dementia , 2006, NeuroImage.

[27]  H. Matsuda,et al.  Relationship between Delusions and Regional Cerebral Blood Flow in Alzheimer’s Disease , 2005, Dementia and Geriatric Cognitive Disorders.

[28]  G A Chase,et al.  Psychiatric symptoms and nursing home placement of patients with Alzheimer's disease. , 1990, The American journal of psychiatry.

[29]  T. Schormann,et al.  Functional delineation of the human occipito-temporal areas related to face and scene processing. A PET study. , 2000, Brain : a journal of neurology.

[30]  Nadim Joni Shah,et al.  Gender differences in brain networks supporting empathy , 2008, NeuroImage.

[31]  M F Weiner,et al.  The Behavior Rating Scale for Dementia of the Consortium to Establish a Registry for Alzheimer's Disease. The Behavioral Pathology Committee of the Consortium to Establish a Registry for Alzheimer's Disease. , 1995, The American journal of psychiatry.

[32]  Hiroshi Fukuda,et al.  Database of normal human cerebral blood flow measured by SPECT: I. Comparison between I-123-IMP, Tc-99m-HMPAO, and Tc-99m-ECD as referred with O-15 labeled water PET and voxel-based morphometry , 2006, Annals of nuclear medicine.

[33]  Jeffrey L. Cummings,et al.  The spectrum of behavioral changes in Alzheimer's disease , 1996, Neurology.

[34]  T L Babb,et al.  Activity of human hippocampal formation and amygdala neurons during memory testing. , 1978, Electroencephalography and clinical neurophysiology.

[35]  R. Levy,et al.  Neuroanatomical correlates of clinical misidentification and misperception in senile dementia of the Alzheimer type. , 1991, The Journal of clinical psychiatry.

[36]  Albert Gjedde,et al.  Normalization in PET group comparison studies—The importance of a valid reference region , 2008, NeuroImage.

[37]  D. Anderson,et al.  The organic and psychological antecedents of delusional jealousy in old age , 1994 .

[38]  J. Butman,et al.  Neuropsychiatric symptoms as a predictor of caregiver burden in Alzheimer’s disease , 2006, Neuropsychiatric disease and treatment.

[39]  S H Ferris,et al.  Behavioral symptoms in Alzheimer's disease: phenomenology and treatment. , 1987, The Journal of clinical psychiatry.

[40]  M. Folstein,et al.  Clinical diagnosis of Alzheimer's disease: Report of the NINCDS—ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease , 2011, Neurology.

[41]  S. Wisniewski,et al.  Psychotic symptoms in Alzheimer disease: evidence for subtypes. , 2003, The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry.

[42]  K. Ishii,et al.  Alteration of regional cerebral glucose utilization with delusions in Alzheimer's disease. , 1998, The Journal of neuropsychiatry and clinical neurosciences.

[43]  S. Folstein,et al.  "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. , 1975, Journal of psychiatric research.

[44]  Howard J. Rosen,et al.  Neuroanatomical correlates of impaired recognition of emotion in dementia , 2006, Neuropsychologia.

[45]  R. Staff,et al.  Delusions in Alzheimer's Disease: Spet Evidence of Right Hemispheric Dysfunction , 1999, Cortex.

[46]  A. Dale,et al.  Multi-modal imaging predicts memory performance in normal aging and cognitive decline , 2010, Neurobiology of Aging.

[47]  M. Folstein,et al.  Delusions in newly admitted residents of nursing homes. , 1990, The American journal of psychiatry.

[48]  J. Cummings,et al.  Delusional thoughts and regional frontal/temporal cortex metabolism in Alzheimer's disease. , 2003, The American journal of psychiatry.

[49]  N. Nagaratnam,et al.  Misidentification in patients with dementia. , 2003, Archives of gerontology and geriatrics.

[50]  E. Mori,et al.  [Japanese version of the Neuropsychiatric Inventory--a scoring system for neuropsychiatric disturbance in dementia patients]. , 1997, No to shinkei = Brain and nerve.

[51]  J. Gross,et al.  The Neural Bases of Emotion Regulation: Reappraisal and Suppression of Negative Emotion , 2008, Biological Psychiatry.

[52]  M. Ikeda,et al.  Alteration of rCBF in Alzheimer's disease patients with delusions of theft , 2001, Neuroreport.

[53]  R. Harvey.  Review: delusions in dementia. , 1996, Age and ageing.

[54]  R. Post,et al.  Regional brain activity during transient self-induced anxiety and anger in healthy adults , 1999, Biological Psychiatry.

[55]  Magda Tsolaki,et al.  Grouping for behavioral and psychological symptoms in dementia: clinical and biological aspects. Consensus paper of the European Alzheimer disease consortium , 2005, European Psychiatry.

[56]  G. Binetti,et al.  Risk of Mortality and Institutionalization in Demented Patients with Delusions , 1996, Journal of geriatric psychiatry and neurology.

[57]  R. Ownby,et al.  The behavioral pathology in Alzheimer's disease scale (BEHAVE‐AD): factor structure among community‐dwelling Alzheimer's disease patients , 1998, International journal of geriatric psychiatry.

[58]  Tobias Egner,et al.  Neural Dynamics of Rejection Sensitivity , 2007, Journal of Cognitive Neuroscience.

[59]  Jesper Andersson,et al.  Isolating the retrieval of imagined pictures during episodic memory: activation of the left precuneus and left prefrontal cortex , 2003, NeuroImage.