Apoptosis as the basic mechanism of cytotoxic action of ursolic and pomolic acids in glioma cells

[1]  H. Jain,et al.  Insights into the mechanism of natural terpenoids as NF-κB inhibitors: an overview on their anticancer potential. , 2016, Experimental oncology.

[2]  B. Aggarwal,et al.  Ursolic acid, a pentacyclin triterpene, potentiates TRAIL-induced apoptosis through p53-independent up-regulation of death receptors. EVIDENCE FOR THE ROLE OF REACTIVE OXYGEN SPECIES AND JNK. , 2016, The Journal of Biological Chemistry.

[3]  Byoungduck Park,et al.  Pomolic Acid Inhibits Invasion of Breast Cancer Cells Through the Suppression of CXC Chemokine Receptor Type 4 Expression , 2016, Journal of cellular biochemistry.

[4]  A. Sharma,et al.  Ursolic acid (UA): A metabolite with promising therapeutic potential. , 2016, Life sciences.

[5]  Xuan Zhu,et al.  A bioinformatic and mechanistic study elicits the antifibrotic effect of ursolic acid through the attenuation of oxidative stress with the involvement of ERK, PI3K/Akt, and p38 MAPK signaling pathways in human hepatic stellate cells and rat liver , 2015, Drug design, development and therapy.

[6]  E. Novellino,et al.  Combined inhibition of AKT/mTOR and MDM2 enhances Glioblastoma Multiforme cell apoptosis and differentiation of cancer stem cells , 2015, Scientific Reports.

[7]  Ho-Shik Kim,et al.  Nutlin-3 induces BCL2A1 expression by activating ELK1 through the mitochondrial p53-ROS-ERK1/2 pathway. , 2014, International journal of oncology.

[8]  Rui Zhang,et al.  Ursolic acid induces autophagy in U87MG cells via ROS-dependent endoplasmic reticulum stress. , 2014, Chemico-biological interactions.

[9]  Xiaobo Li,et al.  Ursolic acid induces apoptosis through mitochondrial intrinsic pathway and suppression of ERK1/2 MAPK in HeLa cells. , 2014, Journal of pharmacological sciences.

[10]  O. Sinitsyna,et al.  Isolation of pomolic acid from Chamaenerion angustifolium and the evaluation of its potential genotoxicity in bacterial test systems , 2014, Russian Journal of Bioorganic Chemistry.

[11]  Yanli Hao,et al.  Ursolic acid promotes cancer cell death by inducing Atg5‐dependent autophagy , 2013, International journal of cancer.

[12]  Moon‐Moo Kim,et al.  Ursolic acid induces apoptosis of SW480 cells via p53 activation. , 2013, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[13]  A. Alhaider,et al.  Ursolic acid inhibits tumor angiogenesis and induces apoptosis through mitochondrial-dependent pathway in Ehrlich ascites carcinoma tumor. , 2013, Chemico-biological interactions.

[14]  M. Noble,et al.  The structure of an MDM2-Nutlin-3a complex solved by the use of a validated MDM2 surface-entropy reduction mutant. , 2013, Acta crystallographica. Section D, Biological crystallography.

[15]  A. Bishayee,et al.  Ursolic acid in cancer prevention and treatment: molecular targets, pharmacokinetics and clinical studies. , 2013, Biochemical pharmacology.

[16]  X. Liang,et al.  Ursolic acid inhibits growth and induces apoptosis in gemcitabine-resistant human pancreatic cancer via the JNK and PI3K/Akt/NF-κB pathways. , 2012, Oncology reports.

[17]  P. Pandolfi,et al.  The functions and regulation of the PTEN tumour suppressor , 2012, Nature Reviews Molecular Cell Biology.

[18]  K. Black,et al.  Loss of PTEN Is Not Associated with Poor Survival in Newly Diagnosed Glioblastoma Patients of the Temozolomide Era , 2012, PloS one.

[19]  H. Seo,et al.  Induction of apoptotic cell death by ursolic acid through mitochondrial death pathway and extrinsic death receptor pathway in MDA-MB-231 cells , 2011, Archives of pharmacal research.

[20]  B. Aggarwal,et al.  Ursolic Acid, a Pentacyclin Triterpene, Potentiates TRAIL-induced Apoptosis through p53-independent Up-regulation of Death Receptors , 2010, The Journal of Biological Chemistry.

[21]  Tyler T. Risom,et al.  Discovery of pyrrolopyrimidine inhibitors of Akt. , 2010, Bioorganic & medicinal chemistry letters.

[22]  G. Yen,et al.  Ursolic acid, a naturally occurring triterpenoid, suppresses migration and invasion of human breast cancer cells by modulating c-Jun N-terminal kinase, Akt and mammalian target of rapamycin signaling. , 2010, Molecular nutrition & food research.

[23]  N. Xu,et al.  Mutations of PTEN gene in gliomas correlate to tumor differentiation and short-term survival rate. , 2010, Anticancer research.

[24]  Melanie N Laszczyk,et al.  Pentacyclic triterpenes of the lupane, oleanane and ursane group as tools in cancer therapy. , 2009, Planta medica.

[25]  U. Testa,et al.  Triterpenoids as new promising anticancer drugs. , 2009, Anti-cancer drugs.

[26]  Arthur J. Olson,et al.  AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading , 2009, J. Comput. Chem..

[27]  Giulio Cossu,et al.  Magic-Factor 1, a Partial Agonist of Met, Induces Muscle Hypertrophy by Protecting Myogenic Progenitors from Apoptosis , 2008, PloS one.

[28]  D. Koul.  PTEN Signaling pathways in glioblastoma , 2008, Cancer biology & therapy.

[29]  M. Recio,et al.  Anti-inflammatory and apoptotic activities of pomolic acid isolated from Cecropia pachystachya. , 2008, Planta medica.

[30]  C. Gattass,et al.  Pomolic acid-induced apoptosis in cells from patients with chronic myeloid leukemia exhibiting different drug resistance profile , 2007, Investigational New Drugs.

[31]  M. Sporn,et al.  Triterpenoids and rexinoids as multifunctional agents for the prevention and treatment of cancer , 2007, Nature Reviews Cancer.

[32]  G. Amarante-Mendes,et al.  Pomolic acid may overcome multidrug resistance mediated by overexpression of anti-apoptotic Bcl-2 proteins. , 2007, Cancer letters.

[33]  G. Amarante-Mendes,et al.  Pomolic acid triggers mitochondria-dependent apoptotic cell death in leukemia cell line. , 2005, Cancer letters.

[34]  Conrad C. Huang,et al.  UCSF Chimera—A visualization system for exploratory research and analysis , 2004, J. Comput. Chem..

[35]  B. Aggarwal,et al.  From chemoprevention to chemotherapy: common targets and common goals , 2004, Expert opinion on investigational drugs.

[36]  L. Vassilev,et al.  In Vivo Activation of the p53 Pathway by Small-Molecule Antagonists of MDM2 , 2004, Science.

[37]  W. Setzer,et al.  Plant-derived triterpenoids as potential antineoplastic agents. , 2003, Mini reviews in medicinal chemistry.

[38]  W. Goddard,et al.  UFF, a full periodic table force field for molecular mechanics and molecular dynamics simulations , 1992 .

[39]  T. Mosmann.  Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. , 1983, Journal of immunological methods.

[40]  Till Acker,et al.  Isolation and culture of primary glioblastoma cells from human tumor specimens. , 2015, Methods in molecular biology.

[41]  Jong-Hwa Park,et al.  Pomolic acid induces apoptosis in SK-OV-3 human ovarian adenocarcinoma cells through the mitochondrial-mediated intrinsic and death receptor-induced extrinsic pathways. , 2013, Oncology letters.

[42]  J. S. Lee,et al.  Anticancer properties of pomolic acid-induced AMP-activated protein kinase activation in MCF7 human breast cancer cells. , 2012, Biological & pharmaceutical bulletin.

[43]  A. Bishayee,et al.  Triterpenoids as potential agents for the chemoprevention and therapy of breast cancer. , 2011, Frontiers in bioscience.