Source localization of brain electric activity during positive, neutral and negative emotional states

In order to clarify the differences in source localization of brain electric activity between positive, neutral and negative emotional states, we recorded 19-channel, eyes-closed EEG: (a) before and after autogenic training in 12 right-handed normal subjects (5 males, 7 females, mean age 22.3±1.9 years) and (b) during listening to independently assessed joyful and sad music in 12 right-handed normal subjects (5 males, 7 females, mean age 23.6±1.8 years). Forty artifact-free seconds/subject/condition were analyzed using FFT Dipole Approximation and Low Resolution Electromagnetic Tomography (LORETA). Global tests revealed differences (p<0.06) between source gravity center locations of the (excitatory) beta3 frequencies (21.5–30 Hz): (a) before and after autogenic training, and (b) during the two emotional music experiences. Post-hoc, paired t-tests (p<0.2) showed that the sources were located: (a) more posterior-left for beta3 after than before autogenic training, and (b) more posterior-inferior for beta3 during joyful than sad music. LORETA specified (with p<0.05) that autogenic training compared to rest produced the weakest activity in right Brodmann area 6 (frontal lobe), right Brodmann area 6, and middle Brodmann area 10 (frontal lobe) for routine/resting alpha2 frequencies (10.5–12 Hz), excitatory beta2 (18.5–21 Hz), and beta3, respectively. Also, LORETA specified (with p<0.05) that joyful music showed maximally weaker activity than sad music in left Brodmann area 36 (temporal lobe) for routine/resting or inhibitory theta frequencies (6.5–8 Hz). Thus, the three emotional states (positive such as relaxation after autogenic training and during joyful music, neutral such as resting before autogenic training, and negative such as during sad music) were clearly associated with activity of different neural populations in the brain; i.e., positive emotions were generally related to posterior-left-inferior brain electric activity compared to neutral and negative emotions.

[1]  A. Alavi,et al.  Positron emission tomographic studies of perceptual tasks , 1984, Annals of neurology.

[2]  P. Ekman,et al.  Approach-withdrawal and cerebral asymmetry: emotional expression and brain physiology. I. , 1990, Journal of personality and social psychology.

[3]  W M Herrmann,et al.  Reflections on the topics: EEG frequency bands and regulation of vigilance. , 1979, Pharmakopsychiatrie, Neuro-Psychopharmakologie.

[4]  W. Kaschka,et al.  Reduced benzodiazepine receptor binding in panic disorders measured by iomazenil SPECT. , 1995, Journal of psychiatric research.

[5]  J D Watson,et al.  Nonparametric Analysis of Statistic Images from Functional Mapping Experiments , 1996, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[6]  Dylan M. Jones,et al.  Refining the measurement of mood: The UWIST Mood Adjective Checklist , 1990 .

[7]  J. Karhu,et al.  Cerebral benzodiazepine receptor binding and distribution in generalized anxiety disorder: a fractal analysis , 1997, Molecular Psychiatry.

[8]  D Lehmann,et al.  Affective attitudes to face images associated with intracerebral EEG source location before face viewing. , 1999, Brain research. Cognitive brain research.

[9]  Takashi Taniguchi,et al.  Construction of an Affective Value Scale of Music and Examination of Relations between the Scale and a Multiple Mood Scale , 1995 .

[10]  T. Koenig,et al.  Low resolution brain electromagnetic tomography (LORETA) functional imaging in acute, neuroleptic-naive, first-episode, productive schizophrenia , 1999, Psychiatry Research: Neuroimaging.

[11]  D Lehmann,et al.  Source localization of EEG activity during hypnotically induced anxiety and relaxation. , 2001, International journal of psychophysiology : official journal of the International Organization of Psychophysiology.

[12]  D. Lehmann,et al.  EEG reconsidered : from neuroelectric signals to human conscious experience , 2000 .

[13]  G Wiedemann,et al.  Frontal brain asymmetry as a biological substrate of emotions in patients with panic disorders. , 1999, Archives of general psychiatry.

[14]  J Wackermann,et al.  Multichannel EEG fields during and without visual input: frequency domain model source locations and dimensional complexities , 1997, Neuroscience Letters.

[15]  A. Pitkänen,et al.  Abnormal regional benzodiazepine receptor uptake in the prefrontal cortex in patients with panic disorder , 1995, Nuclear medicine communications.

[16]  D Lehmann,et al.  Mood state and brain electric activity in Ecstasy users , 2000, Neuroreport.

[17]  W J Ray,et al.  EEG activity and heart rate during recall of emotional events in hypnosis: relationships with hypnotizability and suggestibility. , 1998, International journal of psychophysiology : official journal of the International Organization of Psychophysiology.

[18]  C M Michel,et al.  Intracerebral dipole source localization for FFT power maps. , 1990, Electroencephalography and clinical neurophysiology.

[19]  M. Torrens.  Co-Planar Stereotaxic Atlas of the Human Brain—3-Dimensional Proportional System: An Approach to Cerebral Imaging, J. Talairach, P. Tournoux. Georg Thieme Verlag, New York (1988), 122 pp., 130 figs. DM 268 , 1990 .

[20]  R. Pascual-Marqui.  Review of methods for solving the EEG inverse problem , 1999 .

[21]  G. Gainotti.  Emotional behavior and hemispheric side of the lesion. , 1972, Cortex; a journal devoted to the study of the nervous system and behavior.

[22]  Dietrich Lehmann,et al.  Faces and emotions: brain electric field sources during covert emotional processing , 1998, Neuropsychologia.