Tyrosine kinase inhibitor Thiotanib targets Bcr-Abl and induces apoptosis and autophagy in human chronic myeloid leukemia cells

[1]  J. Schneider,et al.  Autophagy and Metabolism , 2016 .

[2]  C. Boularan,et al.  Resistance to Inhibitors of Cholinesterase (Ric)-8A and Gαi Contribute to Cytokinesis Abscission by Controlling Vacuolar Protein-Sorting (Vps)34 Activity , 2014, PloS one.

[3]  Kun-Liang Guan,et al.  Autophagy regulation by nutrient signaling , 2013, Cell Research.

[4]  Shao-kai Wang,et al.  Involvement of autophagy in recombinant human arginase-induced cell apoptosis and growth inhibition of malignant melanoma cells , 2014, Applied Microbiology and Biotechnology.

[5]  K. Guan,et al.  Regulation of PIK3C3/VPS34 complexes by MTOR in nutrient stress-induced autophagy , 2013, Autophagy.

[6]  A. Choi,et al.  Autophagic flux and oxidative capacity of skeletal muscles during acute starvation , 2013, Autophagy.

[7]  T. Bouwmeester,et al.  Atg4b-Dependent Autophagic Flux Alleviates Huntington’s Disease Progression , 2013, PloS one.

[8]  H. Aslam,et al.  Bcr-Abl tyrosine kinase inhibitors- current status , 2013, Infectious Agents and Cancer.

[9]  W. Jung,et al.  Cleavage of BCR–ABL transcripts at the T315I point mutation by DNAzyme promotes apoptotic cell death in imatinib-resistant BCR–ABL leukemic cells , 2013, Leukemia.

[10]  Weiwu Wang,et al.  Suppression of Autophagy Enhanced Growth Inhibition and Apoptosis of Interferon-β in Human Glioma Cells , 2013, Molecular Neurobiology.

[11]  Xuejun Jiang,et al.  The ULK1 complex , 2013, Autophagy.

[12]  P. Dubey,et al.  A Facile Total Synthesis for Large-Scale Production of Imatinib Base , 2012 .

[13]  Jai-Sing Yang,et al.  Bufalin increases sensitivity to AKT/mTOR-induced autophagic cell death in SK-HEP-1 human hepatocellular carcinoma cells. , 2012, International journal of oncology.

[14]  Jean Qiu,et al.  A novel image-based cytometry method for autophagy detection in living cells , 2012, Autophagy.

[15]  Chen Li,et al.  Porcine reproductive and respiratory syndrome virus induces autophagy to promote virus replication , 2012, Autophagy.

[16]  P. Li,et al.  Glutamate Induces Mitochondrial Dynamic Imbalance and Autophagy Activation: Preventive Effects of Selenium , 2012, PloS one.

[17]  Jorge Cortes,et al.  Tyrosine kinase inhibitors in acute and chronic leukemias , 2012, Expert opinion on pharmacotherapy.

[18]  D. Dobrota,et al.  Why mitochondria are excellent targets for cancer therapy. , 2012, Klinicka onkologie : casopis Ceske a Slovenske onkologicke spolecnosti.

[19]  J. Chai,et al.  A novel agonistic anti-human death receptor 5 monoclonal antibody with tumoricidal activity induces caspase- and mitochondrial-dependent apoptosis in human leukemia Jurkat cells. , 2011, Cancer biotherapy & radiopharmaceuticals.

[20]  Isei Tanida.  Autophagy basics , 2011, Microbiology and immunology.

[21]  Z. Fan,et al.  Roles of autophagy in cetuximab-mediated cancer therapy against EGFR , 2010, Autophagy.

[22]  Z. Fan,et al.  The epidermal growth factor receptor antibody cetuximab induces autophagy in cancer cells by downregulating HIF-1alpha and Bcl-2 and activating the beclin 1/hVps34 complex. , 2010, Cancer research.

[23]  E. Carreira,et al.  Synthesis of azaspirocycles and their evaluation in drug discovery. , 2010, Angewandte Chemie.

[24]  Franz Schuler,et al.  Oxetanes in drug discovery: structural and synthetic insights. , 2010, Journal of medicinal chemistry.

[25]  M. Talpaz,et al.  CHRONIC MYELOID LEUKEMIA: AFTER A DECADE OF IMATINIB _________________________________________________________ , 2022 .

[26]  D. Green,et al.  Caspase-independent cell death: leaving the set without the final cut , 2008, Oncogene.

[27]  S. Pattingre,et al.  Regulation of macroautophagy by mTOR and Beclin 1 complexes. , 2008, Biochimie.

[28]  F. Lacombe,et al.  Imatinib and Nilotinib induce apoptosis of chronic myeloid leukemia cells through a Bim-dependant pathway modulated by cytokines , 2007, Cancer biology & therapy.

[29]  G. Evan,et al.  Autophagy inhibition enhances therapy-induced apoptosis in a Myc-induced model of lymphoma. , 2007, The Journal of clinical investigation.

[30]  E. White,et al.  Role of Autophagy in Cancer: Management of Metabolic Stress , 2007, Autophagy.

[31]  E. Carreira,et al.  Oxetanes as promising modules in drug discovery. , 2006, Angewandte Chemie.

[32]  T. Niwa,et al.  Design and synthesis of 3-substituted benzamide derivatives as Bcr-Abl kinase inhibitors. , 2006, Bioorganic & medicinal chemistry letters.

[33]  R. Ren,et al.  Mechanisms of BCR–ABL in the pathogenesis of chronic myelogenous leukaemia , 2005, Nature Reviews Cancer.

[34]  A. Kimchi,et al.  Autophagy as a cell death and tumor suppressor mechanism , 2004, Oncogene.

[35]  J. Melo,et al.  The molecular biology of chronic myeloid leukemia. , 2000, Blood.

[36]  Z. Estrov,et al.  The biology of chronic myeloid leukemia. , 1999, The New England journal of medicine.

[37]  D. Cortez,et al.  The BCR-ABL tyrosine kinase inhibits apoptosis by activating a Ras-dependent signaling pathway. , 1996, Oncogene.

[38]  B. Zehnbauer,et al.  Inhibition of apoptosis by BCR-ABL in chronic myeloid leukemia. , 1994, Blood.

[39]  O. Witte,et al.  Tyrosine kinase activity and transformation potency of bcr-abl oncogene products. , 1990, Science.