A selective inhibitor of mitofusin 1-βIIPKC association improves heart failure outcome in rats
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M. Disatnik | D. Mochly‐Rosen | A. Kowaltowski | Nir Qvit | X. Qi | B. Queliconi | P. Dourado | L. R. Bechara | V. Lima | L. Bozi | Juliane C Campos | J. Ferreira | Luiz R G Bechara
[1] U. Wisløff,et al. Endoplasmic reticulum stress impairs cardiomyocyte contractility through JNK-dependent upregulation of BNIP3. , 2018, International journal of cardiology.
[2] R. Vasan,et al. Ceramide Remodeling and Risk of Cardiovascular Events and Mortality , 2018, Journal of the American Heart Association.
[3] Jihui Chen,et al. Mitochondrial Fission Is Required for Angiotensin II-Induced Cardiomyocyte Apoptosis Mediated by a Sirt1-p53 Signaling Pathway , 2018, Front. Pharmacol..
[4] R. Gottlieb,et al. Exercise reestablishes autophagic flux and mitochondrial quality control in heart failure , 2017, Autophagy.
[5] D. Mochly‐Rosen,et al. Engineered Substrate-Specific Delta PKC Antagonists to Enhance Cardiac Therapeutics. , 2016, Angewandte Chemie.
[6] G. Dorn,et al. Correcting mitochondrial fusion by manipulating mitofusin conformations , 2016, Nature.
[7] M. Disatnik,et al. Selective Phosphorylation Inhibitor of Delta Protein Kinase C-Pyruvate Dehydrogenase Kinase Protein-Protein Interactions: Application for Myocardial Injury in Vivo. , 2016, Journal of the American Chemical Society.
[8] D. Mochly‐Rosen,et al. Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH) Protein-Protein Interaction Inhibitor Reveals a Non-catalytic Role for GAPDH Oligomerization in Cell Death* , 2016, The Journal of Biological Chemistry.
[9] L. Scorrano,et al. Extracellular Regulated Kinase Phosphorylates Mitofusin 1 to Control Mitochondrial Morphology and Apoptosis , 2015, Molecular cell.
[10] L. Wilkins. Circulation: Clinical Summaries Original Research Put Into Perspective for the Practicing Clinician , 2008, Circulation.
[11] M. Disatnik,et al. Aldehyde dehydrogenase 2 activation in heart failure restores mitochondrial function and improves ventricular function and remodelling. , 2014, Cardiovascular research.
[12] M. Drazner,et al. 2013 ACCF/AHA guideline for the management of heart failure: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. , 2013, Journal of the American College of Cardiology.
[13] J. Campos,et al. Acute Inhibition of Excessive Mitochondrial Fission After Myocardial Infarction Prevents Long‐term Cardiac Dysfunction , 2013, Journal of the American Heart Association.
[14] D. Mochly‐Rosen,et al. A novel Drp1 inhibitor diminishes aberrant mitochondrial fission and neurotoxicity , 2013, Journal of Cell Science.
[15] J. Campos,et al. Exercise Training Restores Cardiac Protein Quality Control in Heart Failure , 2012, PloS one.
[16] K. Das,et al. Protein kinase C, an elusive therapeutic target? , 2012, Nature Reviews Drug Discovery.
[17] T. Veenstra,et al. Stress-induced phosphorylation and proteasomal degradation of mitofusin 2 facilitates mitochondrial fragmentation and apoptosis. , 2012, Molecules and Cells.
[18] Julio C. B. Ferreira,et al. Protein Quality Control Disruption by PKCβII in Heart Failure; Rescue by the Selective PKCβII Inhibitor, βIIV5-3 , 2012, PloS one.
[19] R. Kloner,et al. An update on cardioprotection: a review of the latest adjunctive therapies to limit myocardial infarction size in clinical trials. , 2012, Journal of the American College of Cardiology.
[20] D. Mozaffarian,et al. Heart disease and stroke statistics--2012 update: a report from the American Heart Association. , 2012, Circulation.
[21] G. Dorn,et al. Mitochondrial Fusion is Essential for Organelle Function and Cardiac Homeostasis , 2011, Circulation research.
[22] D. Bernstein,et al. Pharmacological inhibition of βIIPKC is cardioprotective in late-stage hypertrophy. , 2011, Journal of molecular and cellular cardiology.
[23] Julio C. B. Ferreira,et al. βIIPKC and εPKC isozymes as potential pharmacological targets in cardiac hypertrophy and heart failure. , 2011, Journal of molecular and cellular cardiology.
[24] Daria Mochly-Rosen,et al. PKCβII inhibition attenuates myocardial infarction induced heart failure and is associated with a reduction of fibrosis and pro-inflammatory responses , 2011, Journal of cellular and molecular medicine.
[25] D. Xing,et al. Mitochondrial oxidative stress causes mitochondrial fragmentation via differential modulation of mitochondrial fission–fusion proteins , 2011, The FEBS journal.
[26] K. Kolaja,et al. Cardiotoxicity of kinase inhibitors: the prediction and translation of preclinical models to clinical outcomes , 2011, Nature Reviews Drug Discovery.
[27] R. Sobel,et al. Aberrant mitochondrial fission in neurons induced by protein kinase Cδ under oxidative stress conditions in vivo , 2011, Molecular biology of the cell.
[28] R. Youle,et al. Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin , 2010, The Journal of cell biology.
[29] D. Mochly‐Rosen,et al. Highly Specific Modulators of Protein Kinase C Localization: Applications to Heart Failure. , 2010, Drug discovery today. Disease mechanisms.
[30] Q. Lu,et al. Phosphorylation of Cardiac Troponin I at Protein Kinase C Site Threonine 144 Depresses Cooperative Activation of Thin Filaments* , 2010, The Journal of Biological Chemistry.
[31] E. B. Tahara,et al. Tissue-, substrate-, and site-specific characteristics of mitochondrial reactive oxygen species generation. , 2009, Free radical biology & medicine.
[32] S. Palaniyandi,et al. Protein kinase C in heart failure: a therapeutic target? , 2008, Cardiovascular research.
[33] C. Granger,et al. Intracoronary KAI-9803 as an Adjunct to Primary Percutaneous Coronary Intervention for Acute ST-Segment Elevation Myocardial Infarction , 2008, Circulation.
[34] Cecilia Hidalgo,et al. Changes in mitochondrial dynamics during ceramide-induced cardiomyocyte early apoptosis. , 2008, Cardiovascular research.
[35] A. Kowaltowski,et al. Pharmacological and physiological stimuli do not promote Ca(2+)-sensitive K+ channel activity in isolated heart mitochondria. , 2007, Cardiovascular research.
[36] S. Minucci,et al. Protein Kinase C ß and Prolyl Isomerase 1 Regulate Mitochondrial Effects of the Life-Span Determinant p66Shc , 2007, Science.
[37] K. Mihara,et al. Mitofusin 1 and 2 play distinct roles in mitochondrial fusion reactions via GTPase activity , 2004, Journal of Cell Science.
[38] P. Yock,et al. Inhibition of &dgr;-Protein Kinase C Protects Against Reperfusion Injury of the Ischemic Heart In Vivo , 2003, Circulation.
[39] A. Clerk,et al. Kinases as therapeutic targets for heart failure , 2003, Nature Reviews Drug Discovery.
[40] D. Mochly‐Rosen,et al. Molecular transporters for peptides: delivery of a cardioprotective epsilonPKC agonist peptide into cells and intact ischemic heart using a transport system, R(7). , 2001, Chemistry & biology.
[41] D. Mochly‐Rosen,et al. Binding Specificity for RACK1 Resides in the V5 Region of βII Protein Kinase C* , 2001, The Journal of Biological Chemistry.
[42] S. Vanni,et al. Cardiac Angiotensin II Formation in the Clinical Course of Heart Failure and Its Relationship With Left Ventricular Function , 2001, Circulation research.
[43] D. Mochly‐Rosen,et al. Binding specificity for RACK1 resides in the V5 region of beta II protein kinase C. , 2001, The Journal of biological chemistry.
[44] S. Schwarze,et al. In vivo protein transduction: delivery of a biologically active protein into the mouse. , 1999, Science.
[45] D. Mochly‐Rosen,et al. Peptide modulators of protein–protein interactions in intracellular signaling , 1998, Nature Biotechnology.
[46] R. Bonow,et al. Chronic heart failure in the United States: a manifestation of coronary artery disease. , 1998, Circulation.
[47] D. Mochly‐Rosen,et al. An autoregulatory region in protein kinase C: the pseudoanchoring site. , 1995, Proceedings of the National Academy of Sciences of the United States of America.
[48] J. Caldwell,et al. Cloning of an intracellular receptor for protein kinase C: a homolog of the beta subunit of G proteins. , 1994, Proceedings of the National Academy of Sciences of the United States of America.
[49] X. Huang. Treatment of urinary retention with acupuncture and moxibustion. , 1991, Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan.
[50] D. Lipman,et al. Improved tools for biological sequence comparison. , 1988, Proceedings of the National Academy of Sciences of the United States of America.
[51] N. Kruger,et al. The bradford method for protein quantitation. , 1988, Methods in molecular biology.
[52] M. Karnovsky. THE LOCALIZATION OF CHOLINESTERASE ACTIVITY IN RAT CARDIAC MUSCLE BY ELECTRON MICROSCOPY , 1964, The Journal of cell biology.
[53] T N P JOHNS,et al. EXPERIMENTAL MYOCARDIAL INFARCTION. I. A. METHOD OF CORONARY OCCLUSION IN SMALL ANIMALS , 1954, Annals of surgery.