Two images of Landsat TM/ETM+ which belong to 1990 and 1999 respectively, were used to get the information of Land Use/Cover Change (LUCC) of Sangong River basin. Land surface temperature (LST) of corresponding periods was calculated by using the mono-windows algorithm, Bihong Fu's algorithm and Hongbo Su's algorithm. Based on accuracy assessment, the response of LST to LUCC of this region and the relationship between LST and NDVI were analyzed by combining the LUCC and LST. The results showed that, in this decade (1990-1999), urban development and increasing of land use for agriculture caused significant changes of land use/cover in this region, which led to the land surface temperature rising by 10 in average. As the study area is oasis which is located in the edge of desert, the vegetation had an obvious influence on the LST which showed a negative correlation with vegetation index.