Modeling the dishabituation hierarchy: The role of the primordial hippocampus

We present a neural model for the organization and neural dynamics of the medial pallium, the toad's homolog of mammalian hippocampus. A neural mechanism, called cumulative shrinking, is proposed for mapping temporal responses from the anterior thalamus into a form of population coding referenced by spatial positions. Synaptic plasticity is modeled as an interaction of two dynamic processes which simulates acquisition and both short-term and long-term forgetting. The structure of the medial pallium model plus the plasticity model allows us to provide an account of the neural mechanisms of habituation and dishabituation. Computer simulations demonstrate a remarkable match between the model performance and the original experimental data on which the dishabituation hierarchy was based. A set of model predictions is presented, concerning mechanisms of habituation and cellular organization of the medial pallium

[1]  Michael A. Arbib,et al.  Hierarchical dishabituation of visual discrimination in toads , 1991 .

[2]  C. Judson Herrick,et al.  The amphibian forebrain. VIII. Cerebral hemispheres and pallial primordia , 1933 .

[3]  J. Ewert,et al.  Effects of visual associative conditioning on behavior and cerebral metabolic activity in toads , 1988, Naturwissenschaften.

[4]  J. Ewert,et al.  Stimulus-specific long-term habituation of visually guided orienting behavior toward prey in toads: a14C-2DG study , 1988, Journal of Comparative Physiology A.

[5]  R. F. Thompson,et al.  Modeling the neural substrates of associative learning and memory: a computational approach. , 1987, Psychological review.

[6]  Stephen Grossberg,et al.  Neural dynamics of adaptive sensory-motor control , 1986 .

[7]  J. Ewert.  Tectal Mechanisms That Underlie Prey-Catching and Avoidance Behaviors in Toads , 1984 .

[8]  S. Grossberg,et al.  Adaptive pattern classification and universal recoding: I. Parallel development and coding of neural feature detectors , 1976, Biological Cybernetics.

[9]  F. Cervantes-Pérez,et al.  Modulation of prey-catching behavior in toads: data and modeling , 1991 .

[10]  Richard F. Thompson,et al.  Modeling the Neural Substrates of Associative Learning and Memory: A Computational Approach , 1987 .

[11]  T. Finkenstädt.  Visual Associative Learning: Searching for Behaviorally Relevant Brain Structures in Toads , 1989 .

[12]  G. Lynch,et al.  The neurobiology of learning and memory , 1989, Cognition.

[13]  DeLiang Wang,et al.  SLONN: A Simulation Language for modeling of Neural Networks , 1990, Simul..

[14]  S. Ebbesson,et al.  Organization of the “Nonolfactory” Telencephalon , 1976 .

[15]  P. Groves,et al.  Habituation: a dual-process theory. , 1970, Psychological review.

[16]  D Wang,et al.  A NEURON MODEL FOR COMPUTER SIMULATION OF NEURAL NETS , 1988 .

[17]  J.-P. Ewert,et al.  Neuroethology: Toward a Functional Analysis of Stimulus-Response Mediating and Modulating Neural Circuitries , 1987 .

[18]  J. Ewert,et al.  Excitatory effects following habituation of prey-catching activity in frogs and toads. , 1971, Journal of comparative and physiological psychology.

[19]  M. Arbib,et al.  A model of the neural mechanisms responsible for pattern recognition and stimulus specific habituation in toads , 2004, Biological Cybernetics.

[20]  Michael A. Arbib,et al.  Neural mechanisms of visuomotor coordination: the evolution of Rana computatrix , 1991 .

[21]  E R Kandel,et al.  Cellular analysis of long-term habituation of the gill-withdrawal reflex of Aplysia californica. , 1978, Science.

[22]  E. Kandel.  Cellular basis of behavior: An introduction to behavioral neurobiology. , 1976 .

[23]  J. -P. Ewert,et al.  Configurational prey-selection by individual experience in the toadBufo bufo , 2004, Journal of comparative physiology.

[24]  C. H. Bailey,et al.  Morphological basis of long-term habituation and sensitization in Aplysia. , 1983, Science.

[25]  M. A. Arbib,et al.  How does the toad's visual system discriminate different worm-like stimuli? , 2004, Biological Cybernetics.

[26]  T. Finkenstädt.  Stimulus-Specific Habituation in Toads: 2DG Studies and Lesion Experiments , 1989 .

[27]  DeLiang Wang,et al.  Three neural models which process temporal information , 1988, Neural Networks.

[28]  H. Hoffman.  The olfactory bulb, accessory olfactory bulb, and hemisphere of some anurans , 1963, The Journal of comparative neurology.

[29]  J. Ewert,et al.  Configurational pattern discrimination responsible for dishabituation in common toads Bufo bufo (L.): Behavioral tests of the predictions of a neural model , 1992, Journal of Comparative Physiology A.