Assessing the role of the EGF receptor in the development and progression of pancreatic cancer
暂无分享,去创建一个
[1] D. Hedley,et al. Phase II trial of erlotinib in advanced pancreatic cancer (PC). , 2016, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[2] A. Montagnini,et al. Prognostic significance of epidermal growth factor receptor overexpression in pancreas cancer and nodal metastasis , 2015, ANZ journal of surgery.
[3] P. Jänne,et al. The quest to overcome resistance to EGFR-targeted therapies in cancer , 2013, Nature Medicine.
[4] David Goldstein,et al. Increased survival in pancreatic cancer with nab-paclitaxel plus gemcitabine. , 2013, The New England journal of medicine.
[5] A. Sauvanet,et al. EGFR expression in pancreatic adenocarcinoma. Relationship to tumour morphology and cell adhesion proteins , 2013, Journal of Clinical Pathology.
[6] D. Wheeler,et al. Nuclear EGFR as a molecular target in cancer. , 2013, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.
[7] J. Pearson,et al. Clinical and molecular characterization of HER2 amplified-pancreatic cancer , 2013, Genome Medicine.
[8] N. Tebbutt,et al. Targeting the ERBB family in cancer: couples therapy , 2013, Nature Reviews Cancer.
[9] David T. W. Jones,et al. Signatures of mutational processes in human cancer , 2013, Nature.
[10] M. Choti,et al. Phase 2 study of erlotinib combined with adjuvant chemoradiation and chemotherapy in patients with resectable pancreatic cancer. , 2013, International journal of radiation oncology, biology, physics.
[11] R. Salgia,et al. Nuclear EGFR protein expression predicts poor survival in early stage non-small cell lung cancer. , 2013, Lung cancer.
[12] Wenping Ding,et al. Efficacy and safety profile of combining agents against epidermal growth factor receptor or vascular endothelium growth factor receptor with gemcitabine-based chemotherapy in patients with advanced pancreatic cancer: a meta-analysis. , 2013, Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.].
[13] D. Goldstein,et al. Comparison of chemoradiotherapy (CRT) and chemotherapy (CT) in patients with a locally advanced pancreatic cancer (LAPC) controlled after 4 months of gemcitabine with or without erlotinib: Final results of the international phase III LAP 07 study. , 2013, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[14] V. Heinemann,et al. KRAS mutation status is not predictive for objective response to anti-EGFR treatment with erlotinib in patients with advanced pancreatic cancer , 2013, Journal of Gastroenterology.
[15] R. López,et al. Phase II trial of erlotinib plus capecitabine as first-line treatment for metastatic pancreatic cancer (XELTA study). , 2013, Anticancer research.
[16] U. Mansmann,et al. EGFR pathway biomarkers in erlotinib-treated patients with advanced pancreatic cancer: translational results from the randomised, crossover phase 3 trial AIO-PK0104 , 2012, British Journal of Cancer.
[17] M. Korc,et al. Neoadjuvant cetuximab, twice-weekly gemcitabine, and intensity-modulated radiotherapy (IMRT) in patients with pancreatic adenocarcinoma. , 2012, Annals of oncology : official journal of the European Society for Medical Oncology.
[18] H. Crawford,et al. KRAS above and beyond – EGFR in pancreatic cancer , 2012, Oncotarget.
[19] G. Lopes,et al. Phase II Study of Gemcitabine, Oxaliplatin, and Cetuximab in Advanced Pancreatic Cancer , 2012, American journal of clinical oncology.
[20] Keunchil Park,et al. Randomized phase II study of dacomitinib (PF-00299804), an irreversible pan-human epidermal growth factor receptor inhibitor, versus erlotinib in patients with advanced non-small-cell lung cancer. , 2012, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[21] Jens T Siveke,et al. EGF receptor is required for KRAS-induced pancreatic tumorigenesis. , 2012, Cancer cell.
[22] M. Barbacid,et al. EGF receptor signaling is essential for k-ras oncogene-driven pancreatic ductal adenocarcinoma. , 2012, Cancer cell.
[23] H. Lenz,et al. A phase II randomized study of cetuximab and bevacizumab alone or in combination with gemcitabine as first-line therapy for metastatic pancreatic adenocarcinoma , 2012, Investigational New Drugs.
[24] Gur Pines,et al. The ERBB network: at last, cancer therapy meets systems biology , 2012, Nature Reviews Cancer.
[25] H. Tsuda,et al. Membranous and cytoplasmic expression of epidermal growth factor receptor in metastatic pancreatic ductal adenocarcinoma. , 2012, Experimental and therapeutic medicine.
[26] M. Ducreux,et al. O-0007 Exploratory Serum Biomarker Analyses from BO21129, a Phase II Study of Erlotinib in Second-Line Pancreatic Cancer: Potential Role of Amphiregulin? , 2012 .
[27] Chiun Hsu,et al. DOSE ESCALATION TO RASH FOR ERLOTINIB PLUS GEMCITABINE IN PATIENTS WITH METASTATIC PANCREATIC CANCER: THE PHASE II RACHEL (BO21128) STUDY , 2012 .
[28] F. Lordick,et al. Phase II study of nimotuzumab, a humanized monoclonal anti-epidermal growth factor receptor (EGFR) antibody, in patients with locally advanced or metastatic pancreatic cancer , 2012, Investigational New Drugs.
[29] Y. Ko,et al. Gemcitabine plus erlotinib followed by capecitabine versus capecitabine plus erlotinib followed by gemcitabine in advanced pancreatic cancer: final results of a randomised phase 3 trial of the ‘Arbeitsgemeinschaft Internistische Onkologie’ (AIO-PK0104) , 2012, Gut.
[30] S. Ramaswamy,et al. Systematic identification of genomic markers of drug sensitivity in cancer cells , 2012, Nature.
[31] C. Schmoor,et al. Multicentre phase II trial of trastuzumab and capecitabine in patients with HER2 overexpressing metastatic pancreatic cancer , 2012, British Journal of Cancer.
[32] D. Richel,et al. A phase I/II, non-randomized, feasibility/safety and efficacy study of the combination of everolimus, cetuximab and capecitabine in patients with advanced pancreatic cancer , 2012, Investigational New Drugs.
[33] I. Hwang,et al. A phase II trial of Erlotinib in combination with gemcitabine and cisplatin in advanced pancreatic cancer , 2012, Investigational New Drugs.
[34] Moorthy P Ponnusamy,et al. Targeting the EGFR signaling pathway in cancer therapy , 2012, Expert opinion on therapeutic targets.
[35] D. Wheeler,et al. The nuclear epidermal growth factor receptor signaling network and its role in cancer. , 2011, Discovery medicine.
[36] M. Sliwkowski,et al. A two-in-one antibody against HER3 and EGFR has superior inhibitory activity compared with monospecific antibodies. , 2011, Cancer cell.
[37] Joon-Oh Park,et al. Impact of KRAS Mutations on Clinical Outcomes in Pancreatic Cancer Patients Treated with First-line Gemcitabine-Based Chemotherapy , 2011, Molecular Cancer Therapeutics.
[38] Jeffrey E. Lee,et al. Phase II trial of cetuximab, gemcitabine, and oxaliplatin followed by chemoradiation with cetuximab for locally advanced (T4) pancreatic adenocarcinoma: correlation of Smad4(Dpc4) immunostaining with pattern of disease progression. , 2011, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[39] F. Sarkar,et al. A phase II study of isoflavones, erlotinib, and gemcitabine in advanced pancreatic cancer , 2011, Investigational New Drugs.
[40] Pierre Michel,et al. FOLFIRINOX versus gemcitabine for metastatic pancreatic cancer. , 2011, The New England journal of medicine.
[41] P. Yue,et al. A Functional Nuclear Epidermal Growth Factor Receptor, Src and Stat3 Heteromeric Complex in Pancreatic Cancer Cells , 2011, PloS one.
[42] A. Moser,et al. Phase II Study of Gemcitabine and Erlotinib as Adjuvant Therapy for Patients with Resected Pancreatic Cancer , 2011, Annals of Surgical Oncology.
[43] S. Varadarajulu,et al. A phase I study evaluating the role of the anti-epidermal growth factor receptor (EGFR) antibody cetuximab as a radiosensitizer with chemoradiation for locally advanced pancreatic cancer , 2011, Cancer Chemotherapy and Pharmacology.
[44] E. Van Cutsem,et al. Axitinib plus gemcitabine versus placebo plus gemcitabine in patients with advanced pancreatic adenocarcinoma: a double-blind randomised phase 3 study. , 2011, The Lancet. Oncology.
[45] D. Riese,et al. Ligand stimulation of ErbB4 and a constitutively-active ErbB4 mutant result in different biological responses in human pancreatic tumor cell lines. , 2011, Experimental cell research.
[46] M. Tsao,et al. Molecular predictors of outcome in a phase 3 study of gemcitabine and erlotinib therapy in patients with advanced pancreatic cancer , 2010, Cancer.
[47] L. Fei,et al. Intraductal papillary mucinous neoplasms of the pancreas: diagnosis and management. , 2010, European journal of gastroenterology & hepatology.
[48] P. Harari,et al. Understanding resistance to EGFR inhibitors—impact on future treatment strategies , 2010, Nature Reviews Clinical Oncology.
[49] G. V. Vande Woude,et al. MET kinase inhibitor SGX523 synergizes with epidermal growth factor receptor inhibitor erlotinib in a hepatocyte growth factor-dependent fashion to suppress carcinoma growth. , 2010, Cancer research.
[50] Sabine Tejpar,et al. Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: a retrospective consortium analysis. , 2010, The Lancet. Oncology.
[51] A. Khorana,et al. Phase III study comparing gemcitabine plus cetuximab versus gemcitabine in patients with advanced pancreatic adenocarcinoma: Southwest Oncology Group-directed intergroup trial S0205. , 2010, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[52] F. Lordick,et al. Safety, efficacy and pharmacokinetics of nimotuzumab, a humanized monoclonal anti-epidermal growth factor receptor (EGFR) antibody, in patients with locally advanced or metastatic pancreatic cancer. , 2010, International journal of clinical pharmacology and therapeutics.
[53] R. Kelley,et al. A phase II study of bevacizumab plus erlotinib for gemcitabine-refractory metastatic pancreatic cancer , 2010, Cancer Chemotherapy and Pharmacology.
[54] F. Ali-Osman,et al. Cyclooxygenase-2 Is a Novel Transcriptional Target of the Nuclear EGFR-STAT3 and EGFRvIII-STAT3 Signaling Axes , 2010, Molecular Cancer Research.
[55] D. Wheeler,et al. Nuclear EGFR contributes to acquired resistance to cetuximab , 2009, Oncogene.
[56] A. Bardelli,et al. Biomarkers Predicting Clinical Outcome of Epidermal Growth Factor Receptor–Targeted Therapy in Metastatic Colorectal Cancer , 2009, Journal of the National Cancer Institute.
[57] P. V. van Diest,et al. HER-family gene amplification and expression in resected pancreatic cancer. , 2009, European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology.
[58] M. Hung,et al. Nuclear expression of epidermal growth factor receptor is a novel prognostic value in patients with ovarian cancer , 2009, Molecular carcinogenesis.
[59] K. Wakasa,et al. HER2 overexpression correlates with survival after curative resection of pancreatic cancer , 2009, Cancer science.
[60] David Allard,et al. Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer , 2009, Science.
[61] Y. Bang,et al. A phase II trial of erlotinib in combination with gemcitabine and capecitabine in previously untreated metastatic/recurrent pancreatic cancer: combined analysis with translational research , 2009, Investigational New Drugs.
[62] W. Scheithauer,et al. Phase III trial of bevacizumab in combination with gemcitabine and erlotinib in patients with metastatic pancreatic cancer. , 2009, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[63] A. Hinke,et al. Cetuximab plus gemcitabine/oxaliplatin (GEMOXCET) in first-line metastatic pancreatic cancer: a multicentre phase II study , 2009, British Journal of Cancer.
[64] J. Schlesselman,et al. Phase II Study of Docetaxel and Gefitinib as Second-Line Therapy in Gemcitabine Pretreated Patients with Advanced Pancreatic Cancer , 2009, Oncology.
[65] Dongsheng Tu,et al. K-ras mutations and benefit from cetuximab in advanced colorectal cancer. , 2008, The New England journal of medicine.
[66] Gordon C Jayson,et al. Angiogenesis as a therapeutic target in cancer. , 2008, Clinical medicine.
[67] D. Yee,et al. Acquired resistance to EGFR tyrosine kinase inhibitors in cancer cells is mediated by loss of IGF-binding proteins. , 2008, The Journal of clinical investigation.
[68] B. Bereczky,et al. Evidence for efficient phosphorylation of EGFR and rapid endocytosis of phosphorylated EGFR via the early/late endocytic pathway in a gefitinib-sensitive non-small cell lung cancer cell line , 2008, Molecular Cancer.
[69] M. Hung,et al. Survival of cancer cells is maintained by EGFR independent of its kinase activity. , 2008, Cancer cell.
[70] Manuel Hidalgo,et al. Coordinated epidermal growth factor receptor pathway gene overexpression predicts epidermal growth factor receptor inhibitor sensitivity in pancreatic cancer. , 2008, Cancer research.
[71] G. Tortora,et al. Inhibition of mTOR pathway by everolimus cooperates with EGFR inhibitors in human tumours sensitive and resistant to anti-EGFR drugs , 2008, British Journal of Cancer.
[72] A. Kemona,et al. Expression of EGF and EGFR strongly correlates with metastasis of pancreatic ductal carcinoma. , 2008, Anticancer research.
[73] N. Normanno,et al. The role of the EGFR signaling in tumor microenvironment , 2008, Journal of cellular physiology.
[74] George Fountzilas,et al. Gemcitabine Combined with Gefitinib in Patients with Inoperable or Metastatic Pancreatic Cancer: A Phase II Study of the Hellenic Cooperative Oncology Group with Biomarker Evaluation , 2008, Cancer investigation.
[75] Eric T. Sawey,et al. Matrix metalloproteinase 7 controls pancreatic acinar cell transdifferentiation by activating the Notch signaling pathway , 2007, Proceedings of the National Academy of Sciences.
[76] V. Georgoulias,et al. A Multicenter Phase II Study of Docetaxel in Combination with Gefitinib in Gemcitabine-Pretreated Patients with Advanced/Metastatic Pancreatic Cancer , 2007, Oncology.
[77] R. Hruban,et al. Tumorigenesis and Neoplastic Progression Acinar Cells Contribute to the Molecular Heterogeneity of Pancreatic Intraepithelial Neoplasia , 2007 .
[78] P. Murawa,et al. Erlotinib Plus Gemcitabine Compared With Gemcitabine Alone in Patients With Advanced Pancreatic Cancer: A Phase III Trial of the National Cancer Institute of Canada Clinical Trials Group , 2023, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[79] M. Heslin,et al. Epidermal growth factor receptor (EGFR) is highly conserved in pancreatic cancer , 2007 .
[80] M. Hung,et al. Nuclear‐cytoplasmic transport of EGFR involves receptor endocytosis, importin β1 and CRM1 , 2006, Journal of cellular biochemistry.
[81] A. Bhardwaj,et al. Epidermal Growth Factor Receptor Expression in Pancreatic Carcinoma Using Tissue Microarray Technique , 2006, Digestive Surgery.
[82] Janusz Jankowski,et al. Epidermal Growth Factor Receptor Kinase Domain Mutations in Esophageal and Pancreatic Adenocarcinomas , 2006, Clinical Cancer Research.
[83] H. Tsuda,et al. Potential crosstalk between insulin-like growth factor receptor type 1 and epidermal growth factor receptor in progression and metastasis of pancreatic cancer , 2006, Modern Pathology.
[84] Ralph Weissleder,et al. Both p16(Ink4a) and the p19(Arf)-p53 pathway constrain progression of pancreatic adenocarcinoma in the mouse. , 2006, Proceedings of the National Academy of Sciences of the United States of America.
[85] A. Molven,et al. Molecular analysis of the EGFR-RAS-RAF pathway in pancreatic ductal adenocarcinomas: lack of mutations in the BRAF and EGFR genes , 2006, Virchows Archiv.
[86] R. Hruban,et al. Molecular pathogenesis of pancreatic cancer. , 2006, Annual review of genomics and human genetics.
[87] M. Hung,et al. EGFR signaling pathway in breast cancers: from traditional signal transduction to direct nuclear translocalization , 2006, Breast Cancer Research and Treatment.
[88] Napoleone Ferrara,et al. Angiogenesis as a therapeutic target , 2005, Nature.
[89] S. Leach,et al. Pancreatic epithelial plasticity mediated by acinar cell transdifferentiation and generation of nestin-positive intermediates , 2005, Development.
[90] D. Rimm,et al. Quantitative Determination of Nuclear and Cytoplasmic Epidermal Growth Factor Receptor Expression in Oropharyngeal Squamous Cell Cancer by Using Automated Quantitative Analysis , 2005, Clinical Cancer Research.
[91] Sheng-Chieh Hsu,et al. Nuclear interaction of EGFR and STAT3 in the activation of the iNOS/NO pathway. , 2005, Cancer cell.
[92] H. Lane,et al. ERBB receptors and cancer: the complexity of targeted inhibitors , 2005, Nature Reviews Cancer.
[93] M. Iorio,et al. Role of HER receptors family in development and differentiation , 2004, Journal of cellular physiology.
[94] R. Wolff,et al. Cetuximab, a monoclonal antibody targeting the epidermal growth factor receptor, in combination with gemcitabine for advanced pancreatic cancer: a multicenter phase II Trial. , 2004, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[95] Patricia L. Harris,et al. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. , 2004, The New England journal of medicine.
[96] D. Iannitti,et al. Herceptin and Gemcitabine for Metastatic Pancreatic Cancers That Overexpress HER-2/neu , 2004 .
[97] E. Petricoin,et al. Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse. , 2003, Cancer cell.
[98] J. Cameron,et al. Multicomponent Analysis of the Pancreatic Adenocarcinoma Progression Model Using a Pancreatic Intraepithelial Neoplasia Tissue Microarray , 2003, Modern Pathology.
[99] Masato Nakamura,et al. Epidermal growth factor receptor expression in human pancreatic cancer: Significance for liver metastasis. , 2003, International journal of molecular medicine.
[100] D. Iannitti,et al. Overexpression of the HER-2/ neu Oncogene in Pancreatic Adenocarcinoma , 2001, American journal of clinical oncology.
[101] K. Makino,et al. Nuclear localization of EGF receptor and its potential new role as a transcription factor , 2001, Nature Cell Biology.
[102] T. Mattfeldt,et al. A murine tumor progression model for pancreatic cancer recapitulating the genetic alterations of the human disease. , 2001, Genes & development.
[103] Y. Yarden,et al. Untangling the ErbB signalling network , 2001, Nature Reviews Molecular Cell Biology.
[104] I. Fidler,et al. Blockade of the epidermal growth factor receptor signaling by a novel tyrosine kinase inhibitor leads to apoptosis of endothelial cells and therapy of human pancreatic carcinoma. , 2000, Cancer research.
[105] N. Robert,et al. Multinational study of the efficacy and safety of humanized anti-HER2 monoclonal antibody in women who have HER2-overexpressing metastatic breast cancer that has progressed after chemotherapy for metastatic disease. , 1999, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[106] H. Friess,et al. ErbB‐4 mRNA expression is decreased in non‐metastatic pancreatic cancer , 1999, International journal of cancer.
[107] Y. Nio,et al. Clinicopathological significance of epidermal growth factor and its receptor in human pancreatic cancer. , 1997, Anticancer research.
[108] W. Kabsch,et al. The Ras-RasGAP complex: structural basis for GTPase activation and its loss in oncogenic Ras mutants. , 1997, Science.
[109] M. Korc,et al. Overexpression of transforming growth factor-alpha and epidermal growth factor receptor, but not epidermal growth factor, in exocrine pancreatic tumours in hamsters. , 1996, Carcinogenesis.
[110] S. Goodman,et al. Immunohistochemical evaluation of HER-2/neu expression in pancreatic adenocarcinoma and pancreatic intraepithelial neoplasms. , 1996, Human pathology.
[111] H. Friess,et al. Enhanced erbB-3 expression in human pancreatic cancer correlates with tumor progression. , 1995, Clinical cancer research : an official journal of the American Association for Cancer Research.
[112] B. Nakata,et al. Overexpression of HER2/neu oncogene in pancreatic cancer correlates with shortened survival , 1995, International journal of pancreatology : official journal of the International Association of Pancreatology.
[113] R. Hruban,et al. p53 mutations in pancreatic carcinoma and evidence of common involvement of homocopolymer tracts in DNA microdeletions. , 1994, Cancer research.
[114] H. Friess,et al. Overexpression of HER2/neu oncogene in human pancreatic carcinoma. , 1993, Human pathology.
[115] Y. Yamanaka. The immunohistochemical expressions of epidermal growth factors, epidermal growth factor receptors and c-erbB-2 oncoprotein in human pancreatic cancer. , 1992, Nihon Ika Daigaku zasshi.
[116] R. Palmiter,et al. Overexpression of TGFα in transgenic mice: Induction of epithelial hyperplasia, pancreatic metaplasia, and carcinoma of the breast , 1990, Cell.
[117] G. Merlino,et al. TGFα overexpression in transgenic mice induces liver neoplasia and abnormal development of the mammary gland and pancreas , 1990, Cell.
[118] G. Fleuren,et al. KRAS codon 12 mutations occur very frequently in pancreatic adenocarcinomas. , 1988, Nucleic acids research.
[119] A. Pandiella,et al. HER3 Overexpression and Survival in Solid Tumors , 2012 .
[120] D. Moore,et al. Randomized phase II trial of panitumumab (P), erlotinib (E), and gemcitabine (G) versus erlotinib-gemcitabine in patients with untreated, metastatic pancreatic adenocarcinoma. , 2011, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[121] J. Feliu,et al. Phase II study of a fixed dose-rate infusion of gemcitabine associated with erlotinib in advanced pancreatic cancer , 2010, Cancer Chemotherapy and Pharmacology.
[122] J. Shipley,et al. Lapatinib and gemcitabine for metastatic pancreatic cancer: A phase II study. , 2009, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[123] Michael Goggins,et al. Update on pancreatic intraepithelial neoplasia. , 2008, International journal of clinical and experimental pathology.
[124] N. Hanna,et al. MET Amplification Leads to Gefitinib Resistance in Lung Cancer by Activating ERBB3 Signaling , 2008 .
[125] S. Barni,et al. Cetuximab plus gemcitabine and cisplatin compared with gemcitabine and cisplatin alone in patients with advanced pancreatic cancer: a randomised, multicentre, phase II trial. , 2008, The Lancet. Oncology.
[126] R. DePinho,et al. Genetics and biology of pancreatic ductal adenocarcinoma , 2006, Genes & development.
[127] H. Juhl,et al. Comparative analysis of the EGF-receptor family in pancreatic cancer: expression of HER-4 correlates with a favourable tumor stage. , 2001, International journal of surgical investigation.
[128] National Cancer Institute of Canada Clinical Trials Group. , 1994, Annals of oncology : official journal of the European Society for Medical Oncology.
[129] H. Friess,et al. Coexpression of epidermal growth factor receptor and ligands in human pancreatic cancer is associated with enhanced tumor aggressiveness. , 1993, Anticancer research.
[130] N. Dubrawsky. Cancer statistics , 1989, CA: a cancer journal for clinicians.
[131] B. Burtness,et al. Dovepress Open Access to Scientific and Medical Research Open Access Full Text Article Dovepress Treatment of Pancreatic Cancer with Epidermal Growth Factor Receptor-targeted Therapy , 2022 .