Do you need a pharmacokinetic model, and, if so, which one?

As part of the defense of the first thesis, a survey will be made of the simple pharmacokinetic models. Figure 1 shows the linear mammillary disposition models with from one to three compartments. A disposition model is one representing bolus intravenous administration of the drug. In each case, the concentration in compartment 1 is assumed to represent the whole blood (plasma or serum) concentration of unchanged drug. There is only one "one-compartment open model"; there are three different "two-compartment open models"; there are 13 "three-compartment open models." Within each class, the differences between the models resides in the compartment or compartments from which