Successful Treatment of Generalized Pustular Psoriasis of Pregnancy with Oral Cyclosporine

Generalized pustular psoriasis of pregnancy (GPPP) is a rare dermatosis that usually occurs during the third trimester of pregnancy. The diagnosis is primarily clinical, confirmed by laboratory investigations and histopathological typical findings. Here we report, a 26-year-old, gravida one woman, in 37 weeks of pregnancy, presenting with extensive erythematous, pruritic plaques with peripheral scaling and pustules. Patient was induced at 37 +4  weeks and delivered a healthy 2900g male infant. GPPP was eventually controlled with oral cyclosporine.

[1]  K. Karthikeyan,et al.  Telmisartan aggravates pustular psoriasis , 2015, Journal of pharmacology & pharmacotherapeutics.

[2]  Zhen-ying Zhang,et al.  Personal treatment experience for severe generalized pustular psoriasis of pregnancy: two case reports , 2014, Dermatologic therapy.

[3]  Fernanda Mendes Araújo,et al.  Pustular psoriasis of pregnancy (Impetigo herpetiformis) - Case report* , 2013, Anais brasileiros de dermatologia.

[4]  D. Sotiriadis,et al.  Cyclosporine in the Management of Impetigo Herpetiformis: A Case Report and Review of the Literature , 2013, Case Reports in Dermatology.

[5]  Pensée Wu,et al.  First trimester impetigo herpetiformis in multiparous female successfully treated with oral cyclosporine , 2011, BMJ Case Reports.

[6]  D. Hazarika Generalized pustular psoriasis of pregnancy successfully treated with cyclosporine. , 2009, Indian journal of dermatology, venereology and leprology.

[7]  F. B. Yap Impetigo herpetiformis: a rare dermatosis of pregnancy. , 2009 .

[8]  T. Phillips,et al.  Third-trimester impetigo herpetiformis treated with cyclosporine. , 2007, Journal of the American Academy of Dermatology.

[9]  C. Egan,et al.  Generalized pustular psoriasis of pregnancy treated with narrowband UVB and topical steroids. , 2006, Journal of the American Academy of Dermatology.

[10]  Arthur Rook,et al.  Rook's Textbook of Dermatology , 2004 .

[11]  Lucia Arruda,et al.  Systemic treatment of psoriasis - Part I: methotrexate and acitretin , 2004 .

[12]  L. Azulay-Abulafia,et al.  Pustular psoriasis of pregnancy (impetigo herpetiformis): a report of two cases and review of the literature , 2004 .

[13]  M. Gokcu,et al.  Impetigo herpetiformis unresponsive to therapy in a pregnant adolescent. , 2003, Journal of pediatric and adolescent gynecology.

[14]  O. Oumeish,et al.  Some aspects of impetigo herpetiformis. , 1982, Archives of dermatology.

[15]  A. Shah,et al.  Pustular Psoriasis of Pregnancy with Acrodermatitis Continua of Hallopeau , 2016, Indian journal of dermatology.

[16]  E. Itoi,et al.  Two cases of acrodermatitis continua of Hallopeau associated with generalized arthritis. , 2013, Acta dermatovenerologica Croatica : ADC.

[17]  Felix Boon Bin Yap Impetigo herpetiformis: a rare dermatosis of pregnancy. , 2009, Southern medical journal.

[18]  D. Sasseville,et al.  Dermatologic Diseases of Pregnancy , 2006 .

[19]  Masaaki Ito,et al.  Successful treatment of impetigo herpetiformis with oral cyclosporine during pregnancy. , 2002, Archives of dermatology.