Genetic manipulation of myocardial beta-adrenergic receptor activation and desensitization.
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[1] W. Koch,et al. Targeted &bgr;-Adrenergic Receptor Kinase (&bgr;ARK1) Inhibition by Gene Transfer in Failing Human Hearts , 2004 .
[2] S. Emani,et al. Right ventricular targeted gene transfer of a beta-adrenergic receptor kinase inhibitor improves ventricular performance after pulmonary artery banding. , 2004, The Journal of thoracic and cardiovascular surgery.
[3] R. Spang,et al. Differential myocardial gene expression in the development and rescue of murine heart failure. , 2003, Physiological genomics.
[4] W. Koch,et al. The β-adrenergic receptor kinase in heart failure , 2003 .
[5] G. Dorn,et al. β1-adrenergic receptor polymorphisms confer differential function and predisposition to heart failure , 2003, Nature Medicine.
[6] S. Emani,et al. Catheter-based intracoronary myocardial adenoviral gene delivery: importance of intraluminal seal and infusion flow rate. , 2003, Molecular therapy : the journal of the American Society of Gene Therapy.
[7] J. Murabito,et al. Lifetime Risk for Developing Congestive Heart Failure: The Framingham Heart Study , 2002, Circulation.
[8] W. Koch,et al. Heterotopic transplantation as a model to study functional recovery of unloaded failing hearts. , 2002, The Journal of thoracic and cardiovascular surgery.
[9] W. Koch,et al. Donor heart contractile dysfunction following prolonged ex vivo preservation can be prevented by gene-mediated beta-adrenergic signaling modulation. , 2002, European Journal of Cardio-Thoracic Surgery.
[10] S. Kardia,et al. Synergistic Polymorphisms of β1- and α2C-Adrenergic Receptors and the Risk of Congestive Heart Failure , 2002 .
[11] W. Koch,et al. Myocardial Gene Transfer and Overexpression of &bgr;2-Adrenergic Receptors Potentiates the Functional Recovery of Unloaded Failing Hearts , 2002, Circulation.
[12] R. Lefkowitz,et al. Inhibition of βARK1 restores impaired biochemical β-adrenergic receptor responsiveness but does not rescue CREBA133 induced cardiomyopathy , 2002 .
[13] A. Gerdes,et al. Myocyte Redistribution of GRK2 and GRK5 in Hypertensive, Heart-Failure–Prone Rats , 2002, Hypertension.
[14] W. Koch,et al. Specific β2AR Blocker ICI 118,551 Actively Decreases Contraction Through a Gi-Coupled Form of the β2AR in Myocytes From Failing Human Heart , 2002 .
[15] P. Binkley,et al. Myocardial overexpression of the cardiac b-adrenergic receptor kinase-1 inhibitor (BARKI) delay the development of cardiomyopathy induced by myocardial expression of monocyte chemo-tactic protein-1 (MCP-1) , 2002 .
[16] Robert J. Lefkowitz,et al. Seven-transmembrane-spanning receptors and heart function , 2002, Nature.
[17] W. Koch,et al. Expression of a beta-adrenergic receptor kinase inhibitor reverses dysfunction in failing cardiomyocytes. , 2002, Molecular therapy : the journal of the American Society of Gene Therapy.
[18] G. Andersen,et al. Myocardial distribution and regulation of GRK and beta-arrestin isoforms in congestive heart failure in rats. , 2001, American journal of physiology. Heart and circulatory physiology.
[19] T. Kohout,et al. Augmentation of Cardiac Contractility Mediated by the Human &bgr;3-Adrenergic Receptor Overexpressed in the Hearts of Transgenic Mice , 2001, Circulation.
[20] S. Emani,et al. Right ventricular gene therapy with a beta-adrenergic receptor kinase inhibitor improves survival after pulmonary artery banding. , 2001, The Annals of thoracic surgery.
[21] W. Koch,et al. Ventricular Dysfunction After Cardioplegic Arrest Is Improved After Myocardial Gene Transfer of a &bgr;-Adrenergic Receptor Kinase Inhibitor , 2001, Circulation.
[22] N. Smedira,et al. Mechanical Unloading Restores &bgr;-Adrenergic Responsiveness and Reverses Receptor Downregulation in the Failing Human Heart , 2001, Circulation.
[23] R. Lefkowitz,et al. Regulation of myocardial βARK1 expression in catecholamine-induced cardiac hypertrophy in transgenic mice overexpressing α1B-adrenergic receptors , 2001 .
[24] S. Emani,et al. Cardiac Gene Delivery With Cardiopulmonary Bypass , 2001, Circulation.
[25] C. Scorer,et al. Expression of GRK2 is increased in the left ventricles of cardiomyopathic hamsters , 2001, Basic Research in Cardiology.
[26] R. Lefkowitz,et al. Cardiac βARK1 inhibition prolongs survival and augments β blocker therapy in a mouse model of severe heart failure , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[27] L. Leinwand,et al. Alterations in cardiac adrenergic signaling and calcium cycling differentially affect the progression of cardiomyopathy. , 2001, The Journal of clinical investigation.
[28] S. Emani,et al. In Vivo Ventricular Gene Delivery of a &bgr;-Adrenergic Receptor Kinase Inhibitor to the Failing Heart Reverses Cardiac Dysfunction , 2001, Circulation.
[29] B. Kobilka,et al. Dual modulation of cell survival and cell death by beta(2)-adrenergic signaling in adult mouse cardiac myocytes. , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[30] W. Koch,et al. Physiological Induction of a &bgr;-Adrenergic Receptor Kinase Inhibitor Transgene Preserves &bgr;-Adrenergic Responsiveness in Pressure-Overload Cardiac Hypertrophy , 2000, Circulation.
[31] K. Urasawa,et al. Intracoronary Delivery of Adenovirus Encoding Adenylyl Cyclase VI Increases Left Ventricular Function and cAMP-Generating Capacity , 2000, Circulation.
[32] 川平 洋一. In Vivo Transfer of a β2-Adrenergic Receptor Gene Into the Pressure-Overloaded Rat Heart Enhances Cardiac Response to β-Adrenergic Agonist , 2000 .
[33] W. Koch,et al. The effect of Gi‐protein inactivation on basal, and β1‐ and β2AR‐stimulated contraction of myocytes from transgenic mice overexpressing the β2‐adrenoceptor , 2000 .
[34] R. Lefkowitz,et al. Preservation of myocardial β-adrenergic receptor signaling delays the development of heart failure after myocardial infarction , 2000 .
[35] M. Raynolds,et al. Myocardial-directed overexpression of the human beta(1)-adrenergic receptor in transgenic mice. , 2000, Journal of molecular and cellular cardiology.
[36] G. Dorn,et al. Early and delayed consequences of beta(2)-adrenergic receptor overexpression in mouse hearts: critical role for expression level. , 2000, Circulation.
[37] R. Lefkowitz,et al. Intracoronary adenovirus-mediated delivery and overexpression of the beta(2)-adrenergic receptor in the heart : prospects for molecular ventricular assistance. , 2000, Circulation.
[38] R. Lefkowitz,et al. Hybrid transgenic mice reveal in vivo specificity of G protein-coupled receptor kinases in the heart. , 2000, Circulation research.
[39] R. Lefkowitz,et al. Functional consequences of altering myocardial adrenergic receptor signaling. , 2000, Annual review of physiology.
[40] R. Gainetdinov,et al. Muscarinic Supersensitivity and Impaired Receptor Desensitization in G Protein–Coupled Receptor Kinase 5–Deficient Mice , 1999, Neuron.
[41] Catherine Communal,et al. Opposing Effects of β1- and β2-Adrenergic Receptors on Cardiac Myocyte Apoptosis Role of a Pertussis Toxin–Sensitive G Protein , 1999 .
[42] R. Lefkowitz,et al. Overexpression of the cardiac beta(2)-adrenergic receptor and expression of a beta-adrenergic receptor kinase-1 (betaARK1) inhibitor both increase myocardial contractility but have differential effects on susceptibility to ischemic injury. , 1999, Circulation research.
[43] R. Lefkowitz,et al. In Vivo Inhibition of Elevated Myocardial β-Adrenergic Receptor Kinase Activity in Hybrid Transgenic Mice Restores Normal β-Adrenergic Signaling and Function , 1999 .
[44] R. Lefkowitz,et al. Adenovirus-mediated gene transfer of the β2-adrenergic receptor to donor hearts enhances cardiac function , 1999, Gene Therapy.
[45] R. Lefkowitz,et al. Enhancement of cardiac function after adenoviral-mediated in vivo intracoronary beta2-adrenergic receptor gene delivery. , 1999, The Journal of clinical investigation.
[46] M. Gao,et al. Cardiac-directed adenylyl cyclase expression improves heart function in murine cardiomyopathy. , 1999, Circulation.
[47] Fach,et al. Effect of metoprolol CR/XL in chronic heart failure: Metoprolol CR/XL Randomised Intervention Trial in-Congestive Heart Failure (MERIT-HF) , 1999, The Lancet.
[48] M. Lohse,et al. Progressive hypertrophy and heart failure in beta1-adrenergic receptor transgenic mice. , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[49] D. Glower,et al. Molecular β-adrenergic signaling abnormalities in failing rabbit hearts after infarction. , 1999, American journal of physiology. Heart and circulatory physiology.
[50] G. Dorn,et al. Low- and high-level transgenic expression of β2-adrenergic receptors differentially affect cardiac hypertrophy and function in Gαq-overexpressing mice , 1999 .
[51] R. Palmiter,et al. Enhanced contractility and decreased beta-adrenergic receptor kinase-1 in mice lacking endogenous norepinephrine and epinephrine. , 1999, Circulation.
[52] W. Koch,et al. L-type calcium current and contractility in ventricular myocytes from mice overexpressing the cardiac β2-adrenoceptor , 1999 .
[53] R. Lefkowitz,et al. β2‐Adrenergic receptor overexpression in the developing mouse heart: evidence for targeted modulation of ion channels , 1999, The Journal of physiology.
[54] E. Lakatta,et al. Coupling of beta2-adrenoceptor to Gi proteins and its physiological relevance in murine cardiac myocytes. , 1999, Circulation research.
[55] S. Vatner,et al. Apoptosis of Cardiac Myocytes in Gsα Transgenic Mice , 1999 .
[56] R. Lefkowitz,et al. β-Adrenergic Receptor Kinase-1 Levels in Catecholamine-Induced Myocardial Hypertrophy Regulation by β- but not α1-Adrenergic Stimulation , 1999 .
[57] R. Willette,et al. The myocardial beta-adrenergic system in spontaneously hypertensive heart failure (SHHF) rats. , 1999, Hypertension.
[58] Y. Kaneda,et al. In vivo transfer of a beta 2-adrenergic receptor gene into the pressure-overloaded rat heart enhances cardiac response to beta-adrenergic agonist. , 1998, Circulation.
[59] W. Koch,et al. Myocardial recovery after ischemia and reperfusion injury is significantly impaired in hearts with transgenic overexpression of beta-adrenergic receptor kinase. , 1998, Circulation.
[60] R. Lefkowitz,et al. Reciprocal in vivo regulation of myocardial G protein-coupled receptor kinase expression by beta-adrenergic receptor stimulation and blockade. , 1998, Circulation.
[61] T. McIntosh,et al. The Ile164 beta2-adrenergic receptor polymorphism adversely affects the outcome of congestive heart failure. , 1998, The Journal of clinical investigation.
[62] W. Koch,et al. Myocardial overexpression of GRK3 in transgenic mice: evidence for in vivo selectivity of GRKs. , 1998, American journal of physiology. Heart and circulatory physiology.
[63] Marc G. Caron,et al. Control of Myocardial Contractile Function by the Level of β-Adrenergic Receptor Kinase 1 in Gene-targeted Mice* , 1998, The Journal of Biological Chemistry.
[64] J. Ross,et al. Expression of a beta-adrenergic receptor kinase 1 inhibitor prevents the development of myocardial failure in gene-targeted mice. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[65] Y. Kaneda,et al. In vivo transfer of a β2-Adrenergic receptor gene into the pressure-overloaded rat heart enhances cardiac response to β-adrenergic agonist. Commentary , 1998 .
[66] R. Lefkowitz,et al. Restoration of beta-adrenergic signaling in failing cardiac ventricular myocytes via adenoviral-mediated gene transfer. , 1997, Proceedings of the National Academy of Sciences of the United States of America.
[67] Marc G. Caron,et al. G Protein-coupled Receptor Kinase 3 (GRK3) Gene Disruption Leads to Loss of Odorant Receptor Desensitization* , 1997, The Journal of Biological Chemistry.
[68] P. Ping,et al. Adenylyl cyclase and G protein receptor kinase expression during development of heart failure. , 1997, The American journal of physiology.
[69] W. Koch,et al. Mechanism of β-Adrenergic Receptor Desensitization in Cardiac Hypertrophy Is Increased β-Adrenergic Receptor Kinase* , 1997, The Journal of Biological Chemistry.
[70] J. Benovic,et al. G-protein-coupled receptor kinase activity is increased in hypertension. , 1997, The Journal of clinical investigation.
[71] M. Drazner,et al. Potentiation of beta-adrenergic signaling by adenoviral-mediated gene transfer in adult rabbit ventricular myocytes. , 1997, The Journal of clinical investigation.
[72] M. Elam,et al. Increased cardiac adrenergic drive precedes generalized sympathetic activation in human heart failure. , 1997, Circulation.
[73] M. Caron,et al. Essential role of beta-adrenergic receptor kinase 1 in cardiac development and function. , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[74] R. Lefkowitz,et al. Receptor-specific in vivo desensitization by the G protein-coupled receptor kinase-5 in transgenic mice. , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[75] M. Lohse,et al. Activation of β-Adrenergic Receptor Kinase During Myocardial Ischemia , 1996 .
[76] J. Cohn,et al. The effect of carvedilol on morbidity and mortality in patients with chronic heart failure. U.S. Carvedilol Heart Failure Study Group. , 1996, The New England journal of medicine.
[77] S. Vatner,et al. Adverse Effects of Chronic Endogenous Sympathetic Drive Induced by Cardiac Gsα Overexpression , 1996 .
[78] R. Lefkowitz,et al. Cardiac function in mice overexpressing the beta-adrenergic receptor kinase or a beta ARK inhibitor. , 1995, Science.
[79] R. S. Williams. Boosting cardiac contractility with genes. , 1995, The New England journal of medicine.
[80] R. Lefkowitz,et al. Enhanced myocardial function in transgenic mice overexpressing the beta 2-adrenergic receptor. , 1994, Science.
[81] M. Böhm,et al. Expression of beta-arrestins and beta-adrenergic receptor kinases in the failing human heart. , 1994, Circulation research.
[82] J. Port,et al. Reduced beta 1 receptor messenger RNA abundance in the failing human heart. , 1993, The Journal of clinical investigation.
[83] R. Lefkowitz,et al. Structure and mechanism of the G protein-coupled receptor kinases. , 1993, The Journal of biological chemistry.
[84] M. Packer,et al. The development of positive inotropic agents for chronic heart failure: how have we gone astray? , 1993, Journal of the American College of Cardiology.
[85] R. Lefkowitz,et al. The binding site for the beta gamma subunits of heterotrimeric G proteins on the beta-adrenergic receptor kinase. , 1993, The Journal of biological chemistry.
[86] M. Böhm,et al. Altered expression of beta-adrenergic receptor kinase and beta 1-adrenergic receptors in the failing human heart. , 1993, Circulation.
[87] O. Brodde. Beta-adrenoceptors in cardiac disease. , 1993, Pharmacology & therapeutics.
[88] J. Robbins,et al. Tissue-specific regulation of the alpha-myosin heavy chain gene promoter in transgenic mice. , 1991, The Journal of biological chemistry.
[89] J. Thorner,et al. Model systems for the study of seven-transmembrane-segment receptors. , 1991, Annual review of biochemistry.
[90] M. Caron,et al. Turning off the signal: desensitization of β‐adrenergic receptor function , 1990, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[91] H. C. Hartzell,et al. Regulation of cardiac ion channels by catecholamines, acetylcholine and second messenger systems. , 1988, Progress in biophysics and molecular biology.
[92] S. Jamieson,et al. Beta 1- and beta 2-adrenergic-receptor subpopulations in nonfailing and failing human ventricular myocardium: coupling of both receptor subtypes to muscle contraction and selective beta 1-receptor down-regulation in heart failure. , 1986, Circulation research.
[93] J. Cohn,et al. Plasma norepinephrine as a guide to prognosis in patients with chronic congestive heart failure. , 1984, The New England journal of medicine.
[94] D C Harrison,et al. Decreased catecholamine sensitivity and beta-adrenergic-receptor density in failing human hearts. , 1982, The New England journal of medicine.
[95] R. Ahlquist,et al. A study of the adrenotropic receptors. , 1948, The American journal of physiology.