Genetic manipulation of myocardial beta-adrenergic receptor activation and desensitization.

[1]  W. Koch,et al.  Targeted &bgr;-Adrenergic Receptor Kinase (&bgr;ARK1) Inhibition by Gene Transfer in Failing Human Hearts , 2004 .

[2]  S. Emani,et al.  Right ventricular targeted gene transfer of a beta-adrenergic receptor kinase inhibitor improves ventricular performance after pulmonary artery banding. , 2004, The Journal of thoracic and cardiovascular surgery.

[3]  R. Spang,et al.  Differential myocardial gene expression in the development and rescue of murine heart failure. , 2003, Physiological genomics.

[4]  W. Koch,et al.  The β-adrenergic receptor kinase in heart failure , 2003 .

[5]  G. Dorn,et al.  β1-adrenergic receptor polymorphisms confer differential function and predisposition to heart failure , 2003, Nature Medicine.

[6]  S. Emani,et al.  Catheter-based intracoronary myocardial adenoviral gene delivery: importance of intraluminal seal and infusion flow rate. , 2003, Molecular therapy : the journal of the American Society of Gene Therapy.

[7]  J. Murabito,et al.  Lifetime Risk for Developing Congestive Heart Failure: The Framingham Heart Study , 2002, Circulation.

[8]  W. Koch,et al.  Heterotopic transplantation as a model to study functional recovery of unloaded failing hearts. , 2002, The Journal of thoracic and cardiovascular surgery.

[9]  W. Koch,et al.  Donor heart contractile dysfunction following prolonged ex vivo preservation can be prevented by gene-mediated beta-adrenergic signaling modulation. , 2002, European Journal of Cardio-Thoracic Surgery.

[10]  S. Kardia,et al.  Synergistic Polymorphisms of β1- and α2C-Adrenergic Receptors and the Risk of Congestive Heart Failure , 2002 .

[11]  W. Koch,et al.  Myocardial Gene Transfer and Overexpression of &bgr;2-Adrenergic Receptors Potentiates the Functional Recovery of Unloaded Failing Hearts , 2002, Circulation.

[12]  R. Lefkowitz,et al.  Inhibition of βARK1 restores impaired biochemical β-adrenergic receptor responsiveness but does not rescue CREBA133 induced cardiomyopathy , 2002 .

[13]  A. Gerdes,et al.  Myocyte Redistribution of GRK2 and GRK5 in Hypertensive, Heart-Failure–Prone Rats , 2002, Hypertension.

[14]  W. Koch,et al.  Specific β2AR Blocker ICI 118,551 Actively Decreases Contraction Through a Gi-Coupled Form of the β2AR in Myocytes From Failing Human Heart , 2002 .

[15]  P. Binkley,et al.  Myocardial overexpression of the cardiac b-adrenergic receptor kinase-1 inhibitor (BARKI) delay the development of cardiomyopathy induced by myocardial expression of monocyte chemo-tactic protein-1 (MCP-1) , 2002 .

[16]  Robert J. Lefkowitz,et al.  Seven-transmembrane-spanning receptors and heart function , 2002, Nature.

[17]  W. Koch,et al.  Expression of a beta-adrenergic receptor kinase inhibitor reverses dysfunction in failing cardiomyocytes. , 2002, Molecular therapy : the journal of the American Society of Gene Therapy.

[18]  G. Andersen,et al.  Myocardial distribution and regulation of GRK and beta-arrestin isoforms in congestive heart failure in rats. , 2001, American journal of physiology. Heart and circulatory physiology.

[19]  T. Kohout,et al.  Augmentation of Cardiac Contractility Mediated by the Human &bgr;3-Adrenergic Receptor Overexpressed in the Hearts of Transgenic Mice , 2001, Circulation.

[20]  S. Emani,et al.  Right ventricular gene therapy with a beta-adrenergic receptor kinase inhibitor improves survival after pulmonary artery banding. , 2001, The Annals of thoracic surgery.

[21]  W. Koch,et al.  Ventricular Dysfunction After Cardioplegic Arrest Is Improved After Myocardial Gene Transfer of a &bgr;-Adrenergic Receptor Kinase Inhibitor , 2001, Circulation.

[22]  N. Smedira,et al.  Mechanical Unloading Restores &bgr;-Adrenergic Responsiveness and Reverses Receptor Downregulation in the Failing Human Heart , 2001, Circulation.

[23]  R. Lefkowitz,et al.  Regulation of myocardial βARK1 expression in catecholamine-induced cardiac hypertrophy in transgenic mice overexpressing α1B-adrenergic receptors , 2001 .

[24]  S. Emani,et al.  Cardiac Gene Delivery With Cardiopulmonary Bypass , 2001, Circulation.

[25]  C. Scorer,et al.  Expression of GRK2 is increased in the left ventricles of cardiomyopathic hamsters , 2001, Basic Research in Cardiology.

[26]  R. Lefkowitz,et al.  Cardiac βARK1 inhibition prolongs survival and augments β blocker therapy in a mouse model of severe heart failure , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[27]  L. Leinwand,et al.  Alterations in cardiac adrenergic signaling and calcium cycling differentially affect the progression of cardiomyopathy. , 2001, The Journal of clinical investigation.

[28]  S. Emani,et al.  In Vivo Ventricular Gene Delivery of a &bgr;-Adrenergic Receptor Kinase Inhibitor to the Failing Heart Reverses Cardiac Dysfunction , 2001, Circulation.

[29]  B. Kobilka,et al.  Dual modulation of cell survival and cell death by beta(2)-adrenergic signaling in adult mouse cardiac myocytes. , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[30]  W. Koch,et al.  Physiological Induction of a &bgr;-Adrenergic Receptor Kinase Inhibitor Transgene Preserves &bgr;-Adrenergic Responsiveness in Pressure-Overload Cardiac Hypertrophy , 2000, Circulation.

[31]  K. Urasawa,et al.  Intracoronary Delivery of Adenovirus Encoding Adenylyl Cyclase VI Increases Left Ventricular Function and cAMP-Generating Capacity , 2000, Circulation.

[32]  川平 洋一 In Vivo Transfer of a β2-Adrenergic Receptor Gene Into the Pressure-Overloaded Rat Heart Enhances Cardiac Response to β-Adrenergic Agonist , 2000 .

[33]  W. Koch,et al.  The effect of Gi‐protein inactivation on basal, and β1‐ and β2AR‐stimulated contraction of myocytes from transgenic mice overexpressing the β2‐adrenoceptor , 2000 .

[34]  R. Lefkowitz,et al.  Preservation of myocardial β-adrenergic receptor signaling delays the development of heart failure after myocardial infarction , 2000 .

[35]  M. Raynolds,et al.  Myocardial-directed overexpression of the human beta(1)-adrenergic receptor in transgenic mice. , 2000, Journal of molecular and cellular cardiology.

[36]  G. Dorn,et al.  Early and delayed consequences of beta(2)-adrenergic receptor overexpression in mouse hearts: critical role for expression level. , 2000, Circulation.

[37]  R. Lefkowitz,et al.  Intracoronary adenovirus-mediated delivery and overexpression of the beta(2)-adrenergic receptor in the heart : prospects for molecular ventricular assistance. , 2000, Circulation.

[38]  R. Lefkowitz,et al.  Hybrid transgenic mice reveal in vivo specificity of G protein-coupled receptor kinases in the heart. , 2000, Circulation research.

[39]  R. Lefkowitz,et al.  Functional consequences of altering myocardial adrenergic receptor signaling. , 2000, Annual review of physiology.

[40]  R. Gainetdinov,et al.  Muscarinic Supersensitivity and Impaired Receptor Desensitization in G Protein–Coupled Receptor Kinase 5–Deficient Mice , 1999, Neuron.

[41]  Catherine Communal,et al.  Opposing Effects of β1- and β2-Adrenergic Receptors on Cardiac Myocyte Apoptosis Role of a Pertussis Toxin–Sensitive G Protein , 1999 .

[42]  R. Lefkowitz,et al.  Overexpression of the cardiac beta(2)-adrenergic receptor and expression of a beta-adrenergic receptor kinase-1 (betaARK1) inhibitor both increase myocardial contractility but have differential effects on susceptibility to ischemic injury. , 1999, Circulation research.

[43]  R. Lefkowitz,et al.  In Vivo Inhibition of Elevated Myocardial β-Adrenergic Receptor Kinase Activity in Hybrid Transgenic Mice Restores Normal β-Adrenergic Signaling and Function , 1999 .

[44]  R. Lefkowitz,et al.  Adenovirus-mediated gene transfer of the β2-adrenergic receptor to donor hearts enhances cardiac function , 1999, Gene Therapy.

[45]  R. Lefkowitz,et al.  Enhancement of cardiac function after adenoviral-mediated in vivo intracoronary beta2-adrenergic receptor gene delivery. , 1999, The Journal of clinical investigation.

[46]  M. Gao,et al.  Cardiac-directed adenylyl cyclase expression improves heart function in murine cardiomyopathy. , 1999, Circulation.

[47]  Fach,et al.  Effect of metoprolol CR/XL in chronic heart failure: Metoprolol CR/XL Randomised Intervention Trial in-Congestive Heart Failure (MERIT-HF) , 1999, The Lancet.

[48]  M. Lohse,et al.  Progressive hypertrophy and heart failure in beta1-adrenergic receptor transgenic mice. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[49]  D. Glower,et al.  Molecular β-adrenergic signaling abnormalities in failing rabbit hearts after infarction. , 1999, American journal of physiology. Heart and circulatory physiology.

[50]  G. Dorn,et al.  Low- and high-level transgenic expression of β2-adrenergic receptors differentially affect cardiac hypertrophy and function in Gαq-overexpressing mice , 1999 .

[51]  R. Palmiter,et al.  Enhanced contractility and decreased beta-adrenergic receptor kinase-1 in mice lacking endogenous norepinephrine and epinephrine. , 1999, Circulation.

[52]  W. Koch,et al.  L-type calcium current and contractility in ventricular myocytes from mice overexpressing the cardiac β2-adrenoceptor , 1999 .

[53]  R. Lefkowitz,et al.  β2‐Adrenergic receptor overexpression in the developing mouse heart: evidence for targeted modulation of ion channels , 1999, The Journal of physiology.

[54]  E. Lakatta,et al.  Coupling of beta2-adrenoceptor to Gi proteins and its physiological relevance in murine cardiac myocytes. , 1999, Circulation research.

[55]  S. Vatner,et al.  Apoptosis of Cardiac Myocytes in Gsα Transgenic Mice , 1999 .

[56]  R. Lefkowitz,et al.  β-Adrenergic Receptor Kinase-1 Levels in Catecholamine-Induced Myocardial Hypertrophy Regulation by β- but not α1-Adrenergic Stimulation , 1999 .

[57]  R. Willette,et al.  The myocardial beta-adrenergic system in spontaneously hypertensive heart failure (SHHF) rats. , 1999, Hypertension.

[58]  Y. Kaneda,et al.  In vivo transfer of a beta 2-adrenergic receptor gene into the pressure-overloaded rat heart enhances cardiac response to beta-adrenergic agonist. , 1998, Circulation.

[59]  W. Koch,et al.  Myocardial recovery after ischemia and reperfusion injury is significantly impaired in hearts with transgenic overexpression of beta-adrenergic receptor kinase. , 1998, Circulation.

[60]  R. Lefkowitz,et al.  Reciprocal in vivo regulation of myocardial G protein-coupled receptor kinase expression by beta-adrenergic receptor stimulation and blockade. , 1998, Circulation.

[61]  T. McIntosh,et al.  The Ile164 beta2-adrenergic receptor polymorphism adversely affects the outcome of congestive heart failure. , 1998, The Journal of clinical investigation.

[62]  W. Koch,et al.  Myocardial overexpression of GRK3 in transgenic mice: evidence for in vivo selectivity of GRKs. , 1998, American journal of physiology. Heart and circulatory physiology.

[63]  Marc G. Caron,et al.  Control of Myocardial Contractile Function by the Level of β-Adrenergic Receptor Kinase 1 in Gene-targeted Mice* , 1998, The Journal of Biological Chemistry.

[64]  J. Ross,et al.  Expression of a beta-adrenergic receptor kinase 1 inhibitor prevents the development of myocardial failure in gene-targeted mice. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[65]  Y. Kaneda,et al.  In vivo transfer of a β2-Adrenergic receptor gene into the pressure-overloaded rat heart enhances cardiac response to β-adrenergic agonist. Commentary , 1998 .

[66]  R. Lefkowitz,et al.  Restoration of beta-adrenergic signaling in failing cardiac ventricular myocytes via adenoviral-mediated gene transfer. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[67]  Marc G. Caron,et al.  G Protein-coupled Receptor Kinase 3 (GRK3) Gene Disruption Leads to Loss of Odorant Receptor Desensitization* , 1997, The Journal of Biological Chemistry.

[68]  P. Ping,et al.  Adenylyl cyclase and G protein receptor kinase expression during development of heart failure. , 1997, The American journal of physiology.

[69]  W. Koch,et al.  Mechanism of β-Adrenergic Receptor Desensitization in Cardiac Hypertrophy Is Increased β-Adrenergic Receptor Kinase* , 1997, The Journal of Biological Chemistry.

[70]  J. Benovic,et al.  G-protein-coupled receptor kinase activity is increased in hypertension. , 1997, The Journal of clinical investigation.

[71]  M. Drazner,et al.  Potentiation of beta-adrenergic signaling by adenoviral-mediated gene transfer in adult rabbit ventricular myocytes. , 1997, The Journal of clinical investigation.

[72]  M. Elam,et al.  Increased cardiac adrenergic drive precedes generalized sympathetic activation in human heart failure. , 1997, Circulation.

[73]  M. Caron,et al.  Essential role of beta-adrenergic receptor kinase 1 in cardiac development and function. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[74]  R. Lefkowitz,et al.  Receptor-specific in vivo desensitization by the G protein-coupled receptor kinase-5 in transgenic mice. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[75]  M. Lohse,et al.  Activation of β-Adrenergic Receptor Kinase During Myocardial Ischemia , 1996 .

[76]  J. Cohn,et al.  The effect of carvedilol on morbidity and mortality in patients with chronic heart failure. U.S. Carvedilol Heart Failure Study Group. , 1996, The New England journal of medicine.

[77]  S. Vatner,et al.  Adverse Effects of Chronic Endogenous Sympathetic Drive Induced by Cardiac Gsα Overexpression , 1996 .

[78]  R. Lefkowitz,et al.  Cardiac function in mice overexpressing the beta-adrenergic receptor kinase or a beta ARK inhibitor. , 1995, Science.

[79]  R. S. Williams Boosting cardiac contractility with genes. , 1995, The New England journal of medicine.

[80]  R. Lefkowitz,et al.  Enhanced myocardial function in transgenic mice overexpressing the beta 2-adrenergic receptor. , 1994, Science.

[81]  M. Böhm,et al.  Expression of beta-arrestins and beta-adrenergic receptor kinases in the failing human heart. , 1994, Circulation research.

[82]  J. Port,et al.  Reduced beta 1 receptor messenger RNA abundance in the failing human heart. , 1993, The Journal of clinical investigation.

[83]  R. Lefkowitz,et al.  Structure and mechanism of the G protein-coupled receptor kinases. , 1993, The Journal of biological chemistry.

[84]  M. Packer,et al.  The development of positive inotropic agents for chronic heart failure: how have we gone astray? , 1993, Journal of the American College of Cardiology.

[85]  R. Lefkowitz,et al.  The binding site for the beta gamma subunits of heterotrimeric G proteins on the beta-adrenergic receptor kinase. , 1993, The Journal of biological chemistry.

[86]  M. Böhm,et al.  Altered expression of beta-adrenergic receptor kinase and beta 1-adrenergic receptors in the failing human heart. , 1993, Circulation.

[87]  O. Brodde Beta-adrenoceptors in cardiac disease. , 1993, Pharmacology & therapeutics.

[88]  J. Robbins,et al.  Tissue-specific regulation of the alpha-myosin heavy chain gene promoter in transgenic mice. , 1991, The Journal of biological chemistry.

[89]  J. Thorner,et al.  Model systems for the study of seven-transmembrane-segment receptors. , 1991, Annual review of biochemistry.

[90]  M. Caron,et al.  Turning off the signal: desensitization of β‐adrenergic receptor function , 1990, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[91]  H. C. Hartzell,et al.  Regulation of cardiac ion channels by catecholamines, acetylcholine and second messenger systems. , 1988, Progress in biophysics and molecular biology.

[92]  S. Jamieson,et al.  Beta 1- and beta 2-adrenergic-receptor subpopulations in nonfailing and failing human ventricular myocardium: coupling of both receptor subtypes to muscle contraction and selective beta 1-receptor down-regulation in heart failure. , 1986, Circulation research.

[93]  J. Cohn,et al.  Plasma norepinephrine as a guide to prognosis in patients with chronic congestive heart failure. , 1984, The New England journal of medicine.

[94]  D C Harrison,et al.  Decreased catecholamine sensitivity and beta-adrenergic-receptor density in failing human hearts. , 1982, The New England journal of medicine.

[95]  R. Ahlquist,et al.  A study of the adrenotropic receptors. , 1948, The American journal of physiology.