Influence of Endothelial Cells on Vascular Smooth Muscle Cells Phenotype after Irradiation Implication in Radiation-Induced Vascular Damages

Damage to vessels is one of the most common effects of therapeutic irradiation on normal tissues. We undertook a study in patients treated with preoperative radiotherapy and demonstrated in vivo the importance of proliferation, migration

[1]  L. Truong,et al.  Essential Role of Smad3 in Angiotensin II–Induced Vascular Fibrosis , 2006, Circulation research.

[2]  J. Egido,et al.  Endothelin-1, via ETA Receptor and Independently of Transforming Growth Factor-&bgr;, Increases the Connective Tissue Growth Factor in Vascular Smooth Muscle Cells , 2005, Circulation research.

[3]  J. Egido,et al.  Angiotensin II Activates the Smad Pathway in Vascular Smooth Muscle Cells by a Transforming Growth Factor-β–Independent Mechanism , 2005, Circulation.

[4]  Dieter Raithel,et al.  Connective Tissue Growth Factor Is Overexpressed in Complicated Atherosclerotic Plaques and Induces Mononuclear Cell Chemotaxis In Vitro , 2005, Arteriosclerosis, thrombosis, and vascular biology.

[5]  J. Bourhis,et al.  Global gene expression profiles reveal an increase in mRNA levels of collagens, MMPs, and TIMPs in late radiation enteritis. , 2004, American journal of physiology. Gastrointestinal and liver physiology.

[6]  B. Perbal.  CCN proteins: multifunctional signalling regulators , 2004, The Lancet.

[7]  M. Gaugler,et al.  Irradiation Increases the Interactions of Platelets with the Endothelium In Vivo: Analysis by Intravital Microscopy , 2003, Radiation research.

[8]  C Norman Coleman,et al.  Effects of radiation on normal tissue: consequences and mechanisms. , 2003, The Lancet. Oncology.

[9]  J. Panés,et al.  Relative roles of ICAM-1 and VCAM-1 in the pathogenesis of experimental radiation-induced intestinal inflammation. , 2003, International journal of radiation oncology, biology, physics.

[10]  O. Kemmotsu,et al.  Normalization by edaravone, a free radical scavenger, of irradiation-reduced endothelial nitric oxide synthase expression. , 2003, European journal of pharmacology.

[11]  C. Haie-meder,et al.  Fibrogenic signals in patients with radiation enteritis are associated with increased connective tissue growth factor expression. , 2003, International journal of radiation oncology, biology, physics.

[12]  Ruediger C. Braun-Dullaeus,et al.  Vascular proliferation and atherosclerosis: New perspectives and therapeutic strategies , 2002, Nature Medicine.

[13]  L. Fink,et al.  Deficiency of microvascular thrombomodulin and up-regulation of protease-activated receptor-1 in irradiated rat intestine: possible link between endothelial dysfunction and chronic radiation fibrosis. , 2002, The American journal of pathology.

[14]  B. Hinz,et al.  Myofibroblasts and mechano-regulation of connective tissue remodelling , 2002, Nature Reviews Molecular Cell Biology.

[15]  James B. Mitchell,et al.  Mice lacking Smad3 are protected against cutaneous injury induced by ionizing radiation. , 2002, The American journal of pathology.

[16]  D. Dichek,et al.  Plasminogen Activator Inhibitor Type 1 Increases Neointima Formation in Balloon-Injured Rat Carotid Arteries , 2001, Circulation.

[17]  P. Visser,et al.  Irradiated versus nonirradiated endothelial cells: effect on proliferation of vascular smooth muscle cells. , 2001, Journal of vascular and interventional radiology : JVIR.

[18]  J. Panés,et al.  Role of P‐selectin in radiation‐induced intestinal inflammatory damage , 2001, International journal of cancer.

[19]  W. Fan,et al.  Connective tissue growth factor (CTGF) stimulates vascular smooth muscle cell growth and migration in vitro. , 2000, European journal of cell biology.

[20]  D. Vaughan,et al.  Aldosterone modulates plasminogen activator inhibitor-1 and glomerulosclerosis in vivo. , 2000, Kidney international.

[21]  M. Martin,et al.  TGF-beta1 and radiation fibrosis: a master switch and a specific therapeutic target? , 2000, International journal of radiation oncology, biology, physics.

[22]  E. Nabel,et al.  Nitric oxide modulates expression of cell cycle regulatory proteins: a cytostatic strategy for inhibition of human vascular smooth muscle cell proliferation. , 2000, Circulation.

[23]  A. Newby,et al.  Molecular mechanisms in intimal hyperplasia , 2000, The Journal of pathology.

[24]  T. Sugihara,et al.  Preferential impairment of nitric oxide-mediated endothelium-dependent relaxation in human cervical arteries after irradiation. , 1999, Circulation.

[25]  Shant Kumar,et al.  Irradiation induces upregulation of CD31 in human endothelial cells. , 1999, Arteriosclerosis, thrombosis, and vascular biology.

[26]  M. Hauer-Jensen,et al.  Cellular sources of transforming growth factor-beta isoforms in early and chronic radiation enteropathy. , 1998, The American journal of pathology.

[27]  J. Panés,et al.  Role of leukocyte-endothelial cell adhesion in radiation-induced microvascular dysfunction in rats. , 1995, Gastroenterology.

[28]  C. Peiró,et al.  Influence of endothelium on cultured vascular smooth muscle cell proliferation. , 1995, Hypertension.

[29]  D. Loskutoff,et al.  Increased type 1 plasminogen activator inhibitor gene expression in atherosclerotic human arteries. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[30]  H. Bartelink,et al.  Increased risk of ischemic stroke after radiotherapy on the neck in patients younger than 60 years. , 2002, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[31]  E. D. De Robertis,et al.  Connective-tissue growth factor (CTGF) modulates cell signalling by BMP and TGF-beta. , 2002, Nature cell biology.

[32]  J. Massagué.  How cells read TGF-beta signals. , 2000, Nature reviews. Molecular cell biology.

[33]  R. Ross,et al.  Cell biology of atherosclerosis. , 1995, Annual review of physiology.

[34]  V. Grégoire,et al.  Radiotherapy of the Nitric Oxide Pathway : Implications for Tumor Irradiation-induced Angiogenesis through the Up-regulation Updated Version Cited Articles Citing Articles E-mail Alerts Irradiation-induced Angiogenesis through the Up-regulation of the Nitric Oxide Pathway: Implications for Tumor Rad , 2022 .