Machine Learning-based Prediction of ICU Patient Mortality at Time of Admission

In this paper we describe the application of machine learning techniques to the prediction of hospital Intensive Care Unit (ICU) patient mortality. A large dataset of over 58,000 ICU admissions from the MIMIC III database was used in the development, training and evaluation of a number of all-condition patient mortality predictive models. Evaluation results are presented, showing favorable performance comparing with existing studies, in the specific context that this work presents models making predictions for patients of all conditions as opposed to restricting to patients with a given condition or group of conditions, and the models are developed using only input attributes that are patient administrative data available at time of hospital admission. In this way, our models provide a unique utility for ICU mortality prediction in terms of their being applicable to all patients and at the earliest point in time of admission and utilizing a minimal and routinely collected set of patient administrative data.

[1]  J. Hanley,et al.  The meaning and use of the area under a receiver operating characteristic (ROC) curve. , 1982, Radiology.

[2]  Robert Steele,et al.  Future Personal Health Records as a Foundation for Computational Health , 2009, ICCSA.

[3]  William A Knaus,et al.  Changes in hospital mortality for United States intensive care unit admissions from 1988 to 2012 , 2013, Critical Care.

[4]  L. Tarassenko,et al.  Dynamic Data During Hypotensive Episode Improves Mortality Predictions Among Patients With Sepsis and Hypotension* , 2013, Critical care medicine.

[5]  Robert Steele,et al.  Personal health record architectures: Technology infrastructure implications and dependencies , 2012, J. Assoc. Inf. Sci. Technol..

[6]  Cyril Ferdynus,et al.  A Comparison of a Machine Learning Model with EuroSCORE II in Predicting Mortality after Elective Cardiac Surgery: A Decision Curve Analysis , 2017, PloS one.

[7]  S. Lemeshow,et al.  A new Simplified Acute Physiology Score (SAPS II) based on a European/North American multicenter study. , 1993, JAMA.

[8]  Robert Steele,et al.  Elderly persons' perception and acceptance of using wireless sensor networks to assist healthcare , 2009, Int. J. Medical Informatics.

[9]  William Fleischman,et al.  Prediction of In-hospital Mortality in Emergency Department Patients With Sepsis: A Local Big Data-Driven, Machine Learning Approach. , 2016, Academic emergency medicine : official journal of the Society for Academic Emergency Medicine.

[10]  Peter Szolovits,et al.  MIMIC-III, a freely accessible critical care database , 2016, Scientific Data.

[11]  M. J. van der Laan,et al.  Mortality prediction in intensive care units with the Super ICU Learner Algorithm (SICULA): a population-based study. , 2015, The Lancet. Respiratory medicine.

[12]  M. Motwani,et al.  Machine learning for prediction of all-cause mortality in patients with suspected coronary artery disease: a 5-year multicentre prospective registry analysis , 2016, European heart journal.