Mutual effect of cerebral amyloid β and peripheral lymphocytes in cognitively normal older individuals

We hypothesized that cerebral amyloid accumulation is reflected in the periphery in the pre‐dementia stage and used flow cytometry to investigate the peripheral lymphocytes as an easily accessible biomarker to observe neuro‐inflammation. We aimed to determine whether peripheral lymphocytes are related to the cortical amyloid burden or vice versa in cognitively normal older subjects.

[1]  F. Yasuno,et al.  Low amyloid‐β deposition correlates with high education in cognitively normal older adults: a pilot study , 2015, International journal of geriatric psychiatry.

[2]  Michael Deppe,et al.  Clinical relevance of specific T-cell activation in the blood and cerebrospinal fluid of patients with mild Alzheimer's disease , 2015, Neurobiology of Aging.

[3]  E. Remmerswaal,et al.  Characteristics of differentiated CD8+ and CD4+ T cells present in the human brain , 2013, Acta Neuropathologica.

[4]  Michael S. McGrath,et al.  Systemic immune system alterations in early stages of Alzheimer's disease , 2013, Journal of Neuroimmunology.

[5]  B. Engelhardt,et al.  The anatomical and cellular basis of immune surveillance in the central nervous system , 2012, Nature Reviews Immunology.

[6]  F. Yasuno,et al.  Increased binding of peripheral benzodiazepine receptor in mild cognitive impairment–dementia converters measured by positron emission tomography with [11C]DAA1106 , 2012, Psychiatry Research: Neuroimaging.

[7]  P. Kubes,et al.  Immune surveillance in the central nervous system , 2012, Nature Neuroscience.

[8]  H. Soininen,et al.  CSF biomarkers for Alzheimer disease correlate with cortical brain biopsy findings , 2012, Neurology.

[9]  J. Landowski,et al.  Beta-Amyloid Peptides Enhance the Proliferative Response of Activated CD4+CD28+ Lymphocytes from Alzheimer Disease Patients and from Healthy Elderly , 2012, PloS one.

[10]  J. O'Sullivan,et al.  Frequency and function of regulatory T cells after ischaemic stroke in humans , 2012, Journal of Neuroimmunology.

[11]  G. Pawelec,et al.  Immune profiling of Alzheimer patients , 2012, Journal of Neuroimmunology.

[12]  J. Kornak,et al.  Amyloid Vs Fdg-pet in the Differential Diagnosis of Ad And , 2022 .

[13]  S Ourselin,et al.  β-Amyloid burden in the temporal neocortex is related to hippocampal atrophy in elderly subjects without dementia , 2010, Neurology.

[14]  Bo Li,et al.  Amyloid β Interaction with Receptor for Advanced Glycation End Products Up-Regulates Brain Endothelial CCR5 Expression and Promotes T Cells Crossing the Blood-Brain Barrier1 , 2009, The Journal of Immunology.

[15]  F. Yasuno,et al.  Increased Binding of Peripheral Benzodiazepine Receptor in Alzheimer's Disease Measured by Positron Emission Tomography with [11C]DAA1106 , 2008, Biological Psychiatry.

[16]  R. P. Maguire,et al.  Consensus Nomenclature for in vivo Imaging of Reversibly Binding Radioligands , 2007, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[17]  J. Julien,et al.  Bone Marrow-Derived Microglia Play a Critical Role in Restricting Senile Plaque Formation in Alzheimer's Disease , 2006, Neuron.

[18]  W. Klunk,et al.  Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound‐B , 2004, Annals of neurology.

[19]  J. Aarli,et al.  Role of cytokines in neurological disorders. , 2003, Current medicinal chemistry.

[20]  R. Mrak,et al.  Interleukin‐1 in the genesis and progression of and risk for development of neuronal degeneration in Alzheimer’s disease , 2002, Journal of leukocyte biology.

[21]  Makoto Inoue,et al.  Template-Based Method for Multiple Volumes of Interest of Human Brain PET Images , 2002, NeuroImage.

[22]  Masanori Kato,et al.  Occurrence of T cells in the brain of Alzheimer's disease and other neurological diseases , 2002, Journal of Neuroimmunology.

[23]  C. Plata-salamán,et al.  Inflammation and Alzheimer’s disease , 2000, Neurobiology of Aging.

[24]  R. Weller.  Pathology of Cerebrospinal Fluid and Interstitial Fluid of the CNS: Significance for Alzheimer Disease, Prion Disorders and Multiple Sclerosis , 1998, Journal of neuropathology and experimental neurology.

[25]  N. Volkow,et al.  Distribution Volume Ratios without Blood Sampling from Graphical Analysis of PET Data , 1996, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[26]  Jerry L Prince,et al.  Measurement of Radiotracer Concentration in Brain Gray Matter Using Positron Emission Tomography: MRI-Based Correction for Partial Volume Effects , 1992, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[27]  S. Folstein,et al.  "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. , 1975, Journal of psychiatric research.

[28]  R. Maccioni,et al.  Neuroinflammation: implications for the pathogenesis and molecular diagnosis of Alzheimer's disease. , 2008, Archives of medical research.

[29]  A. Batra,et al.  Altered lymphocyte distribution in Alzheimer's disease. , 2007, Journal of psychiatric research.

[30]  R. Flavell,et al.  T-cells in alzheimer’s disease , 2007, NeuroMolecular Medicine.