Flawed experimental design reveals the need for guidelines requiring appropriate positive controls in endocrine disruption research.

Frederick S. vom Saal,* Benson T. Akingbemi,† Scott M. Belcher,‡ David A. Crain,§ David Crews,{ Linda C. Guidice,jj Patricia A. Hunt,jjj Csaba Leranth,jjjj John Peterson Myers,# Angel Nadal,** Nicholas Olea,†† Vasantha Padmanabhan, Cheryl S. Rosenfeld, Alan Schneyer, Gilbert Schoenfelder, Carlos Sonnenschein, Ana M. Soto, Richard W. Stahlhut, Shanna H. Swan, Laura N. Vandenberg, Hong-Sheng Wang, Cheryl S. Watson, Wade V. Welshons, and Robert T. Zoeller

[1]  C. Richter,et al.  In vivo effects of bisphenol A in laboratory rodent studies. , 2007, Reproductive toxicology.

[2]  John Peterson Myers,et al.  A Clash of Old and New Scientific Concepts in Toxicity, with Important Implications for Public Health , 2009, Environmental health perspectives.

[3]  Frederick S vom Saal,et al.  Estrogenic chemicals in plastic and oral contraceptives disrupt development of the fetal mouse prostate and urethra. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[4]  Koji Arizono,et al.  Why Public Health Agencies Cannot Depend on Good Laboratory Practices as a Criterion for Selecting Data: The Case of Bisphenol A , 2008, Environmental health perspectives.

[5]  Saralees Nadarajah,et al.  Letter to the editor , 2007, Int. Trans. Oper. Res..

[6]  L. R. Harris,et al.  Normal reproductive organ development in CF-1 mice following prenatal exposure to bisphenol A. , 1999, Toxicological sciences : an official journal of the Society of Toxicology.

[7]  J. Furr,et al.  Gestational and lactational exposure to ethinyl estradiol, but not bisphenol A, decreases androgen-dependent reproductive organ weights and epididymal sperm abundance in the male long evans hooded rat. , 2008, Toxicological sciences : an official journal of the Society of Toxicology.

[8]  K. Crofton,et al.  In utero and lactational exposure to bisphenol A, in contrast to ethinyl estradiol, does not alter sexually dimorphic behavior, puberty, fertility, and anatomy of female LE rats. , 2010, Toxicological sciences : an official journal of the Society of Toxicology.

[9]  R. Tyl,et al.  Two-generation reproductive toxicity study of dietary bisphenol A in CD-1 (Swiss) mice. , 2008, Toxicological sciences : an official journal of the Society of Toxicology.

[10]  S Z Cagen,et al.  Three-generation reproductive toxicity study of dietary bisphenol A in CD Sprague-Dawley rats. , 2002, Toxicological sciences : an official journal of the Society of Toxicology.

[11]  J. Haseman,et al.  Altered prostate growth and daily sperm production in male mice exposed prenatally to subclinical doses of 17alpha-ethinyl oestradiol. , 2001, Human reproduction.

[12]  P. Phillips,et al.  Time-course, dose-response, and age comparative sensitivity of N-methyl carbamates in rats. , 2010, Toxicological sciences : an official journal of the Society of Toxicology.

[13]  W. Welshons,et al.  Large effects from small exposures. II. The importance of positive controls in low-dose research on bisphenol A. , 2006, Environmental research.