A programmable synthetic lineage-control network that differentiates human IPSCs into glucose-sensitive insulin-secreting beta-like cells
暂无分享,去创建一个
[1] Martin Fussenegger,et al. Synthetic gene network restoring endogenous pituitary–thyroid feedback control in experimental Graves’ disease , 2016, Proceedings of the National Academy of Sciences.
[2] Linda G. Griffith,et al. Genetically engineering self-organization of human pluripotent stem cells into a liver bud-like tissue using Gata6 , 2016, Nature Communications.
[3] Martin Fussenegger,et al. Implantable synthetic cytokine converter cells with AND-gate logic treat experimental psoriasis , 2015, Science Translational Medicine.
[4] T. Kieffer,et al. Replacing and safeguarding pancreatic β cells for diabetes , 2015, Science Translational Medicine.
[5] T. Kieffer,et al. Differentiation of human pluripotent stem cells into β-cells: Potential and challenges. , 2015, Best practice & research. Clinical endocrinology & metabolism.
[6] Austin G Smith,et al. Towards consistent generation of pancreatic lineage progenitors from human pluripotent stem cells , 2015, Philosophical Transactions of the Royal Society B: Biological Sciences.
[7] S. Bonner-Weir,et al. MAFA and T3 Drive Maturation of Both Fetal Human Islets and Insulin-Producing Cells Differentiated From hESC. , 2015, The Journal of clinical endocrinology and metabolism.
[8] E. Stanley,et al. Efficient Generation of NKX6-1+ Pancreatic Progenitors from Multiple Human Pluripotent Stem Cell Lines , 2015, Stem cell reports.
[9] G. Szot,et al. Tolerance induction and reversal of diabetes in mice transplanted with human embryonic stem cell-derived pancreatic endoderm. , 2015, Cell stem cell.
[10] Martin Fussenegger,et al. Mind-controlled transgene expression by a wireless-powered optogenetic designer cell implant , 2014, Nature Communications.
[11] D. Melton,et al. Generation of Functional Human Pancreatic β Cells In Vitro , 2014, Cell.
[12] James D. Johnson,et al. Reversal of diabetes with insulin-producing cells derived in vitro from human pluripotent stem cells , 2014, Nature Biotechnology.
[13] R. Stein,et al. Revealing transcription factors during human pancreatic β cell development , 2014, Trends in Endocrinology & Metabolism.
[14] R. Maehr,et al. De Novo Formation of Insulin-Producing “Neo-β Cell Islets” from Intestinal Crypts , 2014, Cell reports.
[15] D. Melton,et al. In vivo reprogramming of pancreatic acinar cells to three islet endocrine subtypes , 2014, eLife.
[16] D. Gifford,et al. Differentiated human stem cells resemble fetal, not adult, β cells , 2014, Proceedings of the National Academy of Sciences.
[17] Martin Fussenegger,et al. A closed-loop synthetic gene circuit for the treatment of diet-induced obesity in mice , 2013, Nature Communications.
[18] L. Bouwens,et al. The use of stem cells for pancreatic regeneration in diabetes mellitus , 2013, Nature Reviews Endocrinology.
[19] Mohammad Wahid Ansari,et al. The legal status of in vitro embryos , 2014 .
[20] M. Fussenegger,et al. mRNA transfection-based, feeder-free, induced pluripotent stem cells derived from adipose tissue of a 50-year-old patient. , 2013, Metabolic engineering.
[21] D. Pipeleers,et al. Sustained function of alginate-encapsulated human islet cell implants in the peritoneal cavity of mice leading to a pilot study in a type 1 diabetic patient , 2013, Diabetologia.
[22] Seung K. Kim,et al. Gene regulatory networks governing pancreas development. , 2013, Developmental cell.
[23] Jan Jensen,et al. Notch-mediated post-translational control of Ngn3 protein stability regulates pancreatic patterning and cell fate commitment. , 2013, Developmental biology.
[24] D. Nathan. Diabetes: Long-acting insulin analogues—are benefits worth the cost? , 2012, Nature Reviews Endocrinology.
[25] C. Furusawa,et al. A Dynamical-Systems View of Stem Cell Biology , 2012, Science.
[26] M. Sander,et al. A Notch-dependent molecular circuitry initiates pancreatic endocrine and ductal cell differentiation , 2012, Development.
[27] Martin Fussenegger,et al. The food additive vanillic acid controls transgene expression in mammalian cells and mice , 2011, Nucleic acids research.
[28] M. Fussenegger,et al. A Synthetic Optogenetic Transcription Device Enhances Blood-Glucose Homeostasis in Mice , 2011, Science.
[29] K. Hochedlinger,et al. Harnessing the potential of induced pluripotent stem cells for regenerative medicine , 2011, Nature Cell Biology.
[30] T. Ritter,et al. Role of Lentivirus‐Mediated Overexpression of Programmed Death‐Ligand 1 on Corneal Allograft Survival , 2011, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.
[31] Martin Fussenegger,et al. A designer network coordinating bovine artificial insemination by ovulation-triggered release of implanted sperms. , 2011, Journal of Controlled Release.
[32] G. Szot,et al. Islet Transplantation in Type 1 Diabetic Patients Using Calcineurin Inhibitor-Free Immunosuppressive Protocols Based on T-Cell Adhesion or Costimulation Blockade , 2010, Transplantation.
[33] A. Kirk,et al. Experience with a Novel Efalizumab‐Based Immunosuppressive Regimen to Facilitate Single Donor Islet Cell Transplantation , 2010, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.
[34] J. Schug,et al. Foxa1 and Foxa2 maintain the metabolic and secretory features of the mature beta-cell. , 2010, Molecular endocrinology.
[35] Martin Fussenegger,et al. Self-sufficient control of urate homeostasis in mice by a synthetic circuit , 2010, Nature Biotechnology.
[36] D. Sgroi,et al. Identification of Markers for Newly Formed β-Cells in the Perinatal Period: A Time of Recognized β-Cell Immaturity , 2010, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.
[37] S. Bonner-Weir,et al. Stem cell therapy for type 1 diabetes mellitus , 2010, Nature Reviews Endocrinology.
[38] C. Mayhew,et al. Converting human pluripotent stem cells into β-cells: recent advances and future challenges , 2010, Current opinion in organ transplantation.
[39] Robin Goland,et al. Generation of pluripotent stem cells from patients with type 1 diabetes , 2009, Proceedings of the National Academy of Sciences.
[40] S. Bonner-Weir,et al. Expression of MafA in pancreatic progenitors is detrimental for pancreatic development. , 2009, Developmental biology.
[41] Wei Jiang,et al. Highly efficient differentiation of human ES cells and iPS cells into mature pancreatic insulin-producing cells , 2009, Cell Research.
[42] Hanyi Zhuang,et al. Odor coding by a mammalian receptor repertoire , 2009, Neuroscience Research.
[43] Vladislav V Verkhusha,et al. Monomeric fluorescent timers that change color from blue to red report on cellular trafficking. , 2009, Nature chemical biology.
[44] N. Chao. Faculty Opinions recommendation of In vivo reprogramming of adult pancreatic exocrine cells to beta-cells. , 2008 .
[45] Douglas A. Melton,et al. In vivo reprogramming of adult pancreatic exocrine cells to β-cells , 2008, Nature.
[46] I. Artner,et al. MafA and MafB Regulate Pdx1 Transcription through the Area II Control Region in Pancreatic β Cells*S⃞ , 2008, Journal of Biological Chemistry.
[47] Thomas D. Schmittgen,et al. Analyzing real-time PCR data by the comparative CT method , 2008, Nature Protocols.
[48] E. Kroon,et al. Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo , 2008, Nature Biotechnology.
[49] T. Ichisaka,et al. Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors , 2007, Cell.
[50] T. Graf. Faculty Opinions recommendation of Induction of pluripotent stem cells from adult human fibroblasts by defined factors. , 2007 .
[51] O. Chepurny,et al. A Novel Cyclic Adenosine Monophosphate–Responsive Luciferase Reporter Incorporating a Nonpalindromic Cyclic Adenosine Monophosphate Response Element Provides Optimal Performance for Use in G Protein–Coupled Receptor Drug Discovery Efforts , 2007, Journal of biomolecular screening.
[52] M. Sander,et al. The transcription factors Nkx6.1 and Nkx6.2 possess equivalent activities in promoting beta-cell fate specification in Pdx1+ pancreatic progenitor cells , 2007, Development.
[53] Friedrich Beermann,et al. Temporal control of neurogenin3 activity in pancreas progenitors reveals competence windows for the generation of different endocrine cell types. , 2007, Developmental cell.
[54] L. Sussel,et al. FoxA2, Nkx2.2, and PDX-1 Regulate Islet β-Cell-Specific mafA Expression through Conserved Sequences Located between Base Pairs −8118 and −7750 Upstream from the Transcription Start Site , 2006, Molecular and Cellular Biology.
[55] S. Elledge,et al. A lentiviral microRNA-based system for single-copy polymerase II-regulated RNA interference in mammalian cells. , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[56] D. Kemp,et al. Minireview: transcriptional regulation in pancreatic development. , 2005, Endocrinology.
[57] Camillo Ricordi,et al. Clinical islet transplantation: advances and immunological challenges , 2004, Nature Reviews Immunology.
[58] F. Ris,et al. Ectopic expression of the beta-cell specific transcription factor Pdx1 inhibits glucagon gene transcription , 2003, Diabetologia.
[59] M. Fussenegger,et al. Macrolide-based transgene control in mammalian cells and mice , 2002, Nature Biotechnology.
[60] K. Yasuda,et al. Characterization of the chicken L‐Maf, MafB and c‐Maf in crystallin gene regulation and lens differentiation , 2002, Genes to cells : devoted to molecular & cellular mechanisms.
[61] T. Jensen,et al. Telomerase expression extends the proliferative life-span and maintains the osteogenic potential of human bone marrow stromal cells , 2002, Nature Biotechnology.
[62] Martin Fussenegger,et al. SAMY, a novel mammalian reporter gene derived from Bacillus stearothermophilus α-amylase , 2002 .
[63] M. Atkinson,et al. Type 1 diabetes: new perspectives on disease pathogenesis and treatment , 2001, The Lancet.
[64] M. Fussenegger,et al. Streptogramin-based gene regulation systems for mammalian cells , 2000, Nature Biotechnology.
[65] E. Cerasi,et al. Functional Conservation of Regulatory Elements in thepdx-1 Gene: PDX-1 and Hepatocyte Nuclear Factor 3β Transcription Factors Mediate β-Cell-Specific Expression , 2000, Molecular and Cellular Biology.
[66] L. Sussel,et al. Expression of neurogenin3 reveals an islet cell precursor population in the pancreas. , 2000, Development.
[67] E. Ryan,et al. Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen. , 2000, The New England journal of medicine.
[68] M. Tsai,et al. Regulation of the Pancreatic Islet-Specific GeneBETA2 (neuroD) by Neurogenin 3 , 2000, Molecular and Cellular Biology.
[69] F. Guillemot,et al. neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas. , 2000, Proceedings of the National Academy of Sciences of the United States of America.
[70] M. Vallejo,et al. Differential regulation of basal and cyclic adenosine 3',5'-monophosphate-induced somatostatin gene transcription in neural cells by DNA control elements that bind homeodomain proteins. , 1998, Molecular endocrinology.
[71] D. Sutherland,et al. Reversal of lesions of diabetic nephropathy after pancreas transplantation. , 1998, The New England journal of medicine.
[72] W. Clarke,et al. Early-onset type-ll diabetes mellitus (MODY4) linked to IPF1 , 1997, Nature Genetics.
[73] M. Fussenegger,et al. A novel cytostatic process enhances the productivity of Chinese hamster ovary cells. , 1997, Biotechnology and bioengineering.
[74] H. Edlund,et al. Insulin-promoter-factor 1 is required for pancreas development in mice , 1994, Nature.
[75] J. Assal,et al. [Long-term complications in diabetes mellitus]. , 1989, Acta medica portuguesa.
[76] A. Michael,et al. Recurrent diabetes mellitus in the pancreas iso- and allograft. A light and electron microscopic and immunohistochemical analysis of four cases. , 1985, Laboratory investigation; a journal of technical methods and pathology.
[77] Daniel G. Anderson,et al. Corrigendum: Long-term glycemic control using polymer-encapsulated human stem cell–derived beta cells in immune-competent mice , 2016, Nature Medicine.
[78] Gopika G. Nair,et al. Controlled induction of human pancreatic progenitors produces functional beta‐like cells in vitro , 2015, The EMBO journal.
[79] S. Bonner-Weir,et al. Differentiation of pancreatic endocrine progenitors reversibly blocked by premature induction of MafA. , 2014, Developmental biology.
[80] A. Terzic,et al. Intrapatient variations in type 1 diabetes-specific iPS cell differentiation into insulin-producing cells. , 2013, Molecular therapy : the journal of the American Society of Gene Therapy.
[81] I. Ial,et al. Nature Communications , 2010, Nature Cell Biology.
[82] Martin Fussenegger,et al. SAMY, a novel mammalian reporter gene derived from Bacillus stearothermophilus alpha-amylase. , 2002, Gene.
[83] J. Robertson. Human embryonic stem cell research: ethical and legal issues , 2001, Nature Reviews Genetics.
[84] Ames,et al. Islet Transplantation in Seven Patients with Type 1 Diabetes Mellitus Using a Glucocorticoid-Free Immunosuppressive Regimen , 2000 .
[85] I. Markham,et al. Ethical and legal issues. , 1998, British medical bulletin.
[86] J. M. Talom. Ethical and legal issues. , 1996, TB & HIV.
[87] Development and Stem Cells Research Article , 2022 .