Formation of copper(I) from trace levels of copper(II) as an artifactual impurity in the HPLC analysis of olanzapine.

[1]  T. Harris,et al.  On-column nitrosation of amines observed in liquid chromatography impurity separations employing ammonium hydroxide and acetonitrile as mobile phase. , 2013, Journal of chromatography. A.

[2]  Ke Zhang,et al.  Degradation of a pharmaceutical in HPLC grade methanol containing trace level formaldehyde , 2013, Pharmaceutical development and technology.

[3]  S. Bocian,et al.  Artifacts in liquid-phase separations-system, solvent, and impurity peaks. , 2012, Chemical reviews.

[4]  F. Wang,et al.  Chromatographic studies of unusual on-column degradations of aniline compounds on XBridge Shield RP18 column in high pH aqueous mobile phase. , 2011, Journal of chromatography. A.

[5]  R. Forbes,et al.  Impact of metal-induced degradation on the determination of pharmaceutical compound purity and a strategy for mitigation. , 2011, Journal of pharmaceutical and biomedical analysis.

[6]  S. Baertschi,et al.  Artifactual formylation of the secondary amine of duloxetine hydrochloride by acetonitrile in the presence of titanium dioxide: implications for HPLC method development. , 2010, Journal of pharmaceutical and biomedical analysis.

[7]  Lianming Wu,et al.  Identification and control of metal-chelating chromatographic artifacts in the analysis of a malonohydrazide derivative drug compound. , 2010, Journal of pharmaceutical and biomedical analysis.

[8]  H. Brunner,et al.  Isolation, identification, and synthesis of two oxidative degradation products of olanzapine (LY170053) in solid oral formulations. , 2008, Journal of pharmaceutical sciences.

[9]  A. Marcinek,et al.  Disproportionation of clozapine radical: a link between one-electron oxidation of clozapine and formation of its nitrenium cation. , 2007, Chemical research in toxicology.

[10]  Stuart Williams,et al.  Ghost peaks in reversed-phase gradient HPLC: a review and update. , 2004, Journal of chromatography. A.

[11]  G. Strasser,et al.  Investigations of artifact peaks in sensitive high-performance liquid chromatography methods. , 2000, Journal of chromatography. A.

[12]  J. Uetrecht,et al.  A comparison of the oxidation of clozapine and olanzapine to reactive metabolites and the toxicity of these metabolites to human leukocytes. , 1998, Molecular pharmacology.

[13]  B. Olsen,et al.  Comparison of theory-based and empirical modeling for the prediction of chromatographic behavior in the ion-pairing separation of benzodiazepine-derived pharmaceutical compounds , 1995 .

[14]  A. Bard,et al.  “Encyclopedia of Electrochemistry of the Elements,” Vol. III , 1975 .

[15]  J. Dolan.  On-column sample degradation , 2006 .

[16]  F. Albert Cotton,et al.  Advanced Inorganic Chemistry , 1999 .

[17]  Veronika R. Meyer,et al.  Pitfalls and errors of HPLC in pictures , 1997 .