Design, synthesis and biological evaluation of tasiamide B derivatives as BACE1 inhibitors.
暂无分享,去创建一个
Wei Zhang | Yingxia Li | Wei Zhang | Yechun Xu | S. Ren | Wu-yan Chen | Yechun Xu | Jian Liu | Jian Liu | Wuyan Chen | Sumei Ren | Yingxia Li
[1] Daniel Oehlrich,et al. The evolution of amidine-based brain penetrant BACE1 inhibitors. , 2014, Bioorganic & medicinal chemistry letters.
[2] J. Hardy,et al. The Amyloid Hypothesis of Alzheimer ’ s Disease : Progress and Problems on the Road to Therapeutics , 2009 .
[3] Y. Kiso,et al. Small-sized BACE1 inhibitors , 2006 .
[4] Alison R. Gregro,et al. Structure-based design of potent and selective cell-permeable inhibitors of human beta-secretase (BACE-1). , 2004, Journal of medicinal chemistry.
[5] David G. Tew,et al. Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase , 1999, Molecular and Cellular Neuroscience.
[6] Dongwoo Shin,et al. Design of Potent Inhibitors for Human Brain Memapsin 2 (β-Secretase). , 2000, Journal of the American Chemical Society.
[7] Hannes A. Braun,et al. Modulators and Inhibitors of γ- and β-Secretases , 2006, Neurodegenerative Diseases.
[8] S. Martín-Aragón,et al. Synthesis and evaluation of arylquinones as BACE1 inhibitors, β-amyloid peptide aggregation inhibitors, and destabilizers of preformed β-amyloid fibrils. , 2011, Bioorganic & medicinal chemistry letters.
[9] Yechun Xu,et al. Cyanobacterial peptides as a prototype for the design of potent β-secretase inhibitors and the development of selective chemical probes for other aspartic proteases. , 2012, Journal of medicinal chemistry.
[10] Joseph B. Moon,et al. Design, synthesis, and crystal structure of hydroxyethyl secondary amine-based peptidomimetic inhibitors of human beta-secretase. , 2007, Journal of medicinal chemistry.
[11] Kenichiro Fujiwara,et al. Conformational restriction approach to β-secretase (BACE1) inhibitors III: effective investigation of the binding mode by combinational use of X-ray analysis, isothermal titration calorimetry and theoretical calculations. , 2013, Bioorganic & medicinal chemistry.
[12] Arun K. Ghosh,et al. BACE1 (β-secretase) inhibitors for the treatment of Alzheimer's disease. , 2014, Chemical Society reviews.
[13] J. Macor,et al. P-Glycoprotein Efflux and Other Factors Limit Brain Amyloid β Reduction by β-Site Amyloid Precursor Protein-Cleaving Enzyme 1 Inhibitors in Mice , 2008, Journal of Pharmacology and Experimental Therapeutics.
[14] Arun K. Ghosh,et al. Structure-Based Design: Potent Inhibitors of Human Brain Memapsin 2 (β-Secretase) , 2001 .
[15] L Hong,et al. Structure of the protease domain of memapsin 2 (beta-secretase) complexed with inhibitor. , 2000, Science.
[16] Joseph B. Moon,et al. Design and Synthesis of Hydroxyethylene-Based Peptidomimetic Inhibitors of Human β-Secretase , 2004 .
[17] Bruno Martoglio,et al. Aspartic proteases in drug discovery. , 2007, Current pharmaceutical design.
[18] Yechun Xu,et al. Discovery of pyrazole as C-terminus of selective BACE1 inhibitors. , 2013, European journal of medicinal chemistry.
[19] J. Treanor,et al. Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE. , 1999, Science.
[20] P. Williams,et al. A simple microscale method for determining the relative stereochemistry of statine units. , 2008, The Journal of organic chemistry.
[21] Conformational restriction approach to BACE1 inhibitors II: SAR study of the isocytosine derivatives fixed with a cis-cyclopropane ring. , 2013, Bioorganic & medicinal chemistry letters.
[22] J. Tao,et al. An Improved Enantiospecific Synthesis of Statine and Statine Analogs via 4-(N,N-Dibenzylamino)-3-keto Esters. , 1997, The Journal of organic chemistry.
[23] R. Barbour,et al. Purification and cloning of amyloid precursor protein β-secretase from human brain , 1999, Nature.
[24] Y. Kiso,et al. Advances in the identification of β-secretase inhibitors , 2013, Expert opinion on drug discovery.
[25] Hannes A. Braun,et al. Inhibitors and Modulators of β- and γ-Secretase , 2006 .
[26] J. Tang,et al. Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein. , 2000, Proceedings of the National Academy of Sciences of the United States of America.
[27] Y. Kiso,et al. Recent progress in the drug discovery of non-peptidic BACE1 inhibitors , 2009, Expert opinion on drug discovery.
[28] Alfredo G. Tomasselli,et al. Membrane-anchored aspartyl protease with Alzheimer's disease β-secretase activity , 1999, Nature.
[29] J. Tao,et al. A Stereocontrolled, Convergent Synthesis of Hydroxyethylene Dipeptide Isosteres , 1997 .
[30] E. Novellino,et al. A stereoselective approach to peptidomimetic BACE1 inhibitors. , 2013, European journal of medicinal chemistry.