Pathological Spectrum of Invasive Pulmonary Aspergillosis

In addition to a histological study on experimental pulmonary aspergillosis in rats, pulmonary lesions from 54 autopsies of invasive pulmonary aspergillosis were examined. Three distinct patterns were seen in the lesions of autopsied lungs. The pathological characteristics of each patterns were affected by three important factors: the width and type of necrosis, the distribution of fungi and the degree of the neutrophilic response. The neutrophilic response might play an important role in creating a cavity in the center of the lesion as well as transforming from coagulation necrosis to colliquative necrosis. Furthermore, cytotoxic agents released by the aspergilli and local ischemia might be important factors which modify the features of lesions.

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