From virtual screening hits targeting a cryptic pocket in BACE-1 to a nontoxic brain permeable multitarget anti-Alzheimer lead with disease-modifying and cognition-enhancing effects.
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V. Andrisano | M. Bartolini | M. Bolognesi | M. Loza | J. Brea | M. Scheiner | M. Decker | M. Naldi | R. Sabaté | M. Pallàs | Tiziana Ginex | D. Muñoz-Torrero | J. Gómez-catalán | Caterina Pont | A. De Simone | B. Pérez | F. J. Luque | C. Griñán-Ferré | M. Barenys | Alexia Mattellone | E. Arce | Noemí Martínez | Yolanda Soriano-Fernández | F. Luque | Michael Decker