Germline mutations in the p73 gene do not predispose to familial prostate‐brain cancer

Analysis of high‐risk prostate cancer (PC) families with at least one confirmed case of primary brain cancer (BC) has identified a region of genetic linkage on chromosome 1p36 termed CAPB. The p36 region of chromosome one has been reported to have frequent loss of heterozygosity (LOH) in brain and central nervous system (CNS) tumors and epidemiological studies have shown an increased relative risk of BC and tumors of the CNS in PC families. In 1997 a reported tumor suppressor with high homology to p53, termed p73, was mapped to the p36 region of chromosome one. Here, we examine the p73 gene as a potential candidate for CAPB.

[1]  Siavash Ghaffari,et al.  A candidate prostate cancer susceptibility gene at chromosome 17p , 2001, Nature Genetics.

[2]  B. Pützer,et al.  Role of the p53-homologue p73 in E2F1-induced apoptosis , 2000, Nature Genetics.

[3]  K. Heimdal,et al.  Suggestive evidence for a site specific prostate cancer gene on chromosome 1p36 , 2000, Journal of medical genetics.

[4]  J. Stanford,et al.  Genetics of prostate cancer: too many loci, too few genes. , 2000, American journal of human genetics.

[5]  H. Ngan,et al.  P73 gene expression in ovarian cancer tissues and cell lines. , 2000, Clinical cancer research : an official journal of the American Association for Cancer Research.

[6]  F. McKeon,et al.  An anti-apoptotic role for the p53 family member, p73, during developmental neuron death. , 2000, Science.

[7]  D J Schaid,et al.  Evidence for a prostate cancer-susceptibility locus on chromosome 20. , 2000, American journal of human genetics.

[8]  G Melino,et al.  The p53/p63/p73 family of transcription factors: overlapping and distinct functions. , 2000, Journal of cell science.

[9]  J. Witte,et al.  A genome screen of multiplex sibships with prostate cancer. , 2000, American journal of human genetics.

[10]  W. Kaelin.  The p53 gene family , 1999, Oncogene.

[11]  Reuven Agami,et al.  Interaction of c-Abl and p73α and their collaboration to induce apoptosis , 1999, Nature.

[12]  Jijie Gu,et al.  p73 is regulated by tyrosine kinase c-Abl in the apoptotic response to DNA damage , 1999, Nature.

[13]  C. Harris,et al.  Mutational analysis of p73 and p53 in human cancer cell lines , 1999, Oncogene.

[14]  D. Tindall,et al.  Mutation and expression analysis of the p73 gene in prostate cancer , 1999, The Prostate.

[15]  E. Goode,et al.  Evidence for a rare prostate cancer-susceptibility locus at chromosome 1p36. , 1999, American journal of human genetics.

[16]  D. Tindall,et al.  Overexpression of the wild type p73 gene in human bladder cancer , 1999, Oncogene.

[17]  F. Collins,et al.  Evidence for a prostate cancer susceptibility locus on the X chromosome. , 1998, Nature Genetics.

[18]  D. Tindall,et al.  Activation of p73 silent allele in lung cancer. , 1998, Cancer research.

[19]  W. Vogel,et al.  Predisposing gene for early-onset prostate cancer, localized on chromosome 1q42.2-43. , 1998, American journal of human genetics.

[20]  A. Nakagawara,et al.  Mutation, allelotyping, and transcription analyses of the p73 gene in prostatic carcinoma. , 1998, Cancer Research.

[21]  W. Kaelin,et al.  p73 is a human p53-related protein that can induce apoptosis , 1997, Nature.

[22]  A. Yang,et al.  Monoallelically Expressed Gene Related to p53 at 1p36, a Region Frequently Deleted in Neuroblastoma and Other Human Cancers , 1997, Cell.

[23]  E. Goode,et al.  Linkage analysis of 49 high-risk families does not support a common familial prostate cancer-susceptibility gene at 1q24-25. , 1997, American journal of human genetics.

[24]  D A Meyers,et al.  Major Susceptibility Locus for Prostate Cancer on Chromosome 1 Suggested by a Genome-Wide Search , 1996, Science.

[25]  J. D. Thompson,et al.  Germ-line BRCA1 mutations in selected men with prostate cancer. , 1996, American journal of human genetics.

[26]  T H Beaty,et al.  Risk of cancer in relatives of prostate cancer probands. , 1995, Journal of the National Cancer Institute.

[27]  M H Skolnick,et al.  Systematic population-based assessment of cancer risk in first-degree relatives of cancer probands. , 1994, Journal of the National Cancer Institute.

[28]  T. Beaty,et al.  Hereditary prostate cancer: epidemiologic and clinical features. , 1993, The Journal of urology.