Stereochemical and biochemical aspects of organoboron(III) compounds of hydrazonecarboxamides and hydrazonecarbothioamides

Hydrazonecarboxamides and hydrazonecarbothioamides and their derivatives have important pharmacodynamic significance. In the search for better fungicides and bactericides, organoboron-(III) compounds derived from these ligands were screened for their antifungal and antibacterial activities. The heterocyclic aldimines were prepared by the condensation of (2-furanyl)methanal, (2-thienyl)methanal, (2-pyridinyl)methanal, (1H-indol-2-yl)methanal or 3-phenyl-2-propenal with hydrazinecarboxamide or hydrazinecarbothioamide. Unimolar and bimolar reactions between phenyldihydroxyborane and these ligands have produced PhB(OH)(NO), PhB(NO) 2 , PhB(OH)(NS) and PhB(NS) 2 types of biologically active compounds. Structural assignment has been made through UV, IR and NMR ( 1 H, 11 B and 13 C) spectroscopy. TGA and XRD of a representative compound have also been carried out. The compounds were tested in vitro against a number of fungal and bacterial strains and were found to possess moderate to good toxicity

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