Low Vs. High Alcohol: Central Benefits Vs. Detriments

[1]  Margaret A. Broadwater,et al.  Adolescent alcohol exposure decreases frontostriatal resting‐state functional connectivity in adulthood , 2018, Addiction biology.

[2]  P. Kenny,et al.  MicroRNAs regulate synaptic plasticity underlying drug addiction , 2018, Genes, brain, and behavior.

[3]  Y. Tizabi,et al.  Both ketamine and NBQX attenuate alcohol drinking in male Wistar rats , 2018, Neuroscience Letters.

[4]  W. J. Lynch Modeling the development of drug addiction in male and female animals , 2018, Pharmacology Biochemistry and Behavior.

[5]  J. Kucharska-Mazur,et al.  Cytokine alterations and cognitive impairment in major depressive disorder: From putative mechanisms to novel treatment targets , 2018, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

[6]  W. Dębowska,et al.  Effect of antidepressant treatment on peripheral inflammation markers – A meta-analysis , 2018, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

[7]  R. Duman,et al.  Activity-Dependent Brain-Derived Neurotrophic Factor Release Is Required for the Rapid Antidepressant Actions of Scopolamine , 2018, Biological Psychiatry.

[8]  A. Klintsova,et al.  Neurotrophins in the Brain: Interaction With Alcohol Exposure During Development. , 2017, Vitamins and hormones.

[9]  K. Carey,et al.  Insomnia treatment in the context of alcohol use disorder: A systematic review and meta-analysis. , 2017, Drug and alcohol dependence.

[10]  C. Guerri,et al.  Long-Term Effects of Intermittent Adolescent Alcohol Exposure in Male and Female Rats , 2017, Front. Behav. Neurosci..

[11]  F. Crews,et al.  Alcohol and Stress Activation of Microglia and Neurons: Brain Regional Effects , 2017, Alcoholism, clinical and experimental research.

[12]  K. Dev,et al.  Phospholipase A2 is involved in galactosylsphingosine-induced astrocyte toxicity, neuronal damage and demyelination , 2017, PloS one.

[13]  F. García-García,et al.  Gender differences in the inflammatory cytokine and chemokine profiles induced by binge ethanol drinking in adolescence , 2017, Addiction biology.

[14]  S. Awaworyi Churchill,et al.  Alcohol and depression: Evidence from the 2014 health survey for England. , 2017, Drug and alcohol dependence.

[15]  D. Sarkar,et al.  Turnover of histones and histone variants in postnatal rat brain: effects of alcohol exposure , 2017, Clinical Epigenetics.

[16]  M. Naoi,et al.  Neurotrophic function of phytochemicals for neuroprotection in aging and neurodegenerative disorders: modulation of intracellular signaling and gene expression , 2017, Journal of Neural Transmission.

[17]  J. Miguel-Hidalgo,et al.  MicroRNA-21: Expression in oligodendrocytes and correlation with low myelin mRNAs in depression and alcoholism , 2017, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

[18]  M. Maes,et al.  Associations of Serum Cytokine Receptor Levels with Melancholia, Staging of Illness, Depressive and Manic Phases, and Severity of Depression in Bipolar Disorder , 2016, Molecular Neurobiology.

[19]  R. Taylor,et al.  Alcohol-Induced Increases in Inflammatory Cytokines Are Attenuated by Nicotine in Region-Selective Manner in Male Rats , 2017, Journal of drug and alcohol research.

[20]  R. Duman Sex-specific disease-associated modules for depression , 2017, Nature Medicine.

[21]  M. Filip,et al.  Ceramide and Its Related Neurochemical Networks as Targets for Some Brain Disorder Therapies , 2017, Neurotoxicity Research.

[22]  F. Crews,et al.  Persistent Decreases in Adult Subventricular and Hippocampal Neurogenesis Following Adolescent Intermittent Ethanol Exposure , 2017, Front. Behav. Neurosci..

[23]  N. Delzenne,et al.  A role for the peripheral immune system in the development of alcohol use disorders? , 2017, Neuropharmacology.

[24]  G. Koob,et al.  Genetic studies of alcohol dependence in the context of the addiction cycle , 2017, Neuropharmacology.

[25]  E. Levin,et al.  Ketamine Differentially Attenuates Alcohol Intake in Male Versus Female Alcohol Preferring (P) Rats , 2017, Journal of drug and alcohol research.

[26]  J. Cryan,et al.  The Microbiota, the Gut and the Brain in Eating and Alcohol Use Disorders: A ‘Ménage à Trois’? , 2017, Alcohol and alcoholism.

[27]  J. Morys,et al.  BDNF: A Key Factor with Multipotent Impact on Brain Signaling and Synaptic Plasticity , 2017, Cellular and Molecular Neurobiology.

[28]  J. Kornhuber,et al.  Biological Evidence for Paradoxical Improvement of Psychiatric Disorder Symptoms by Addictive Drugs. , 2017, Trends in pharmacological sciences.

[29]  G. Koob,et al.  Titrating Tipsy Targets: The Neurobiology of Low-Dose Alcohol. , 2017, Trends in pharmacological sciences.

[30]  T. Chikritzhs,et al.  Alcohol Consumption and Mortality From Coronary Heart Disease: An Updated Meta-Analysis of Cohort Studies. , 2017, Journal of studies on alcohol and drugs.

[31]  J. Maggs,et al.  No Benefit of Light to Moderate Drinking for Mortality From Coronary Heart Disease When Better Comparison Groups and Controls Included: A Commentary on Zhao et al. (2017). , 2017, Journal of studies on alcohol and drugs.

[32]  R. Harris,et al.  Mechanistic insights into epigenetic modulation of ethanol consumption. , 2017, Alcohol.

[33]  J. Kornhuber,et al.  Lipids in psychiatric disorders and preventive medicine , 2017, Neuroscience & Biobehavioral Reviews.

[34]  S. Pandey,et al.  Epigenetic mechanisms of alcoholism and stress-related disorders. , 2017, Alcohol.

[35]  A. Regner,et al.  Neurotrauma: The Crosstalk between Neurotrophins and Inflammation in the Acutely Injured Brain , 2017, International journal of molecular sciences.

[36]  P. Kirsch,et al.  From the neurobiological basis of comorbid alcohol dependence and depression to psychological treatment strategies: study protocol of a randomized controlled trial , 2017, BMC Psychiatry.

[37]  F. Crews,et al.  Microglial depletion alters the brain neuroimmune response to acute binge ethanol withdrawal , 2017, Journal of Neuroinflammation.

[38]  A. Csoka,et al.  PACAP Protects Against Ethanol and Nicotine Toxicity in SH-SY5Y Cells: Implications for Drinking-Smoking Co-morbidity , 2017, Neurotoxicity Research.

[39]  F. Crews,et al.  Toll-like receptor signaling and stages of addiction , 2017, Psychopharmacology.

[40]  F. Pavón,et al.  Effects of Intermittent Alcohol Exposure on Emotion and Cognition: A Potential Role for the Endogenous Cannabinoid System and Neuroinflammation , 2017, Front. Behav. Neurosci..

[41]  Wei-Wei Li,et al.  Low-Dose Ethanol Preconditioning Protects Against Oxygen-Glucose Deprivation/Reoxygenation-Induced Neuronal Injury By Activating Large Conductance, Ca2+-Activated K+ Channels In Vitro , 2017, Neuroscience Bulletin.

[42]  L. Ray,et al.  Development of the Neuroimmune Modulator Ibudilast for the Treatment of Alcoholism: A Randomized, Placebo-Controlled, Human Laboratory Trial , 2017, Neuropsychopharmacology.

[43]  K. Ye,et al.  Sex differences in brain‐derived neurotrophic factor signaling and functions , 2017, Journal of neuroscience research.

[44]  M. Wurzelmann,et al.  Therapeutic potential of brain-derived neurotrophic factor (BDNF) and a small molecular mimics of BDNF for traumatic brain injury , 2017, Neural regeneration research.

[45]  J. Kornhuber,et al.  Paradoxical antidepressant effects of alcohol are related to acid sphingomyelinase and its control of sphingolipid homeostasis , 2016, Acta Neuropathologica.

[46]  G. Koob,et al.  Genetic and Pharmacologic Manipulation of TLR4 Has Minimal Impact on Ethanol Consumption in Rodents , 2016, The Journal of Neuroscience.

[47]  T. Harada,et al.  Neuroprotection, Growth Factors and BDNF-TrkB Signalling in Retinal Degeneration , 2016, International journal of molecular sciences.

[48]  N. Volkow,et al.  Neurobiology of addiction: a neurocircuitry analysis. , 2016, The lancet. Psychiatry.

[49]  M. Díaz,et al.  Sub-toxic Ethanol Exposure Modulates Gene Expression and Enzyme Activity of Antioxidant Systems to Provide Neuroprotection in Hippocampal HT22 Cells , 2016, Front. Physiol..

[50]  Y. Tizabi Duality of Antidepressants and Neuroprotectants , 2016, Neurotoxicity Research.

[51]  R. Duman,et al.  Integrating neuroimmune systems in the neurobiology of depression , 2016, Nature Reviews Neuroscience.

[52]  C. la Vecchia,et al.  Effects of moderate beer consumption on health and disease: A consensus document. , 2016, Nutrition, metabolism, and cardiovascular diseases : NMCD.

[53]  B. Christie,et al.  Effects of pre-natal alcohol exposure on hippocampal synaptic plasticity: Sex, age and methodological considerations , 2016, Neuroscience & Biobehavioral Reviews.

[54]  G. Koob,et al.  Sex Differences in Animal Models: Focus on Addiction , 2016, Pharmacological Reviews.

[55]  F. Crews,et al.  A role for histone acetylation mechanisms in adolescent alcohol exposure-induced deficits in hippocampal brain-derived neurotrophic factor expression and neurogenesis markers in adulthood , 2016, Brain Structure and Function.

[56]  L. Monteggia,et al.  BDNF – a key transducer of antidepressant effects , 2016, Neuropharmacology.

[57]  JaneR . Taylor,et al.  Brain-derived neurotrophic factor and addiction: Pathological versus therapeutic effects on drug seeking , 2015, Brain Research.

[58]  D. Bredt,et al.  Translating depression biomarkers for improved targeted therapies , 2015, Neuroscience & Biobehavioral Reviews.

[59]  S. Ghavami,et al.  Effects of Ethanol on the Expression Level of Various BDNF mRNA Isoforms and Their Encoded Protein in the Hippocampus of Adult and Embryonic Rats , 2015, International journal of molecular sciences.

[60]  O. Jones Astrocyte-mediated metaplasticity in the hippocampus: Help or hindrance? , 2015, Neuroscience.

[61]  D. Kim,et al.  The relationship between brain-derived neurotrophic factor and cognitive functions in alcohol-dependent patients: a preliminary study , 2015, Annals of General Psychiatry.

[62]  B. Baune,et al.  An Act of Balance Between Adaptive and Maladaptive Immunity in Depression: a Role for T Lymphocytes , 2015, Journal of Neuroimmune Pharmacology.

[63]  F. Crews,et al.  Mechanisms of neuroimmune gene induction in alcoholism , 2015, Psychopharmacology.

[64]  F. Crews,et al.  Binge ethanol exposure during adolescence leads to a persistent loss of neurogenesis in the dorsal and ventral hippocampus that is associated with impaired adult cognitive functioning , 2015, Front. Neurosci..

[65]  L. Aguayo,et al.  Low concentrations of ethanol protect against synaptotoxicity induced by Aβ in hippocampal neurons , 2015, Neurobiology of Aging.

[66]  Kirk W. Johnson,et al.  Ibudilast reduces alcohol drinking in multiple animal models of alcohol dependence , 2015, Addiction biology.

[67]  K. Horská,et al.  The common pathophysiology underlying the metabolic syndrome, schizophrenia and depression. A review. , 2014, Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia.

[68]  Jia Luo Autophagy and ethanol neurotoxicity , 2014, Autophagy.

[69]  J. Kornhuber,et al.  TNF-α and IL-6 serum levels: neurobiological markers of alcohol consumption in alcohol-dependent patients? , 2014, Alcohol.

[70]  C. Mitchelmore,et al.  Brain derived neurotrophic factor Epigenetic regulation in psychiatric disorders , 2014 .

[71]  Cass,et al.  The Relevance of Blue Moods and Depression in the Context of Smoking and Natural Quitting Rates in People Living with HIV , 2014 .

[72]  S. Neupane,et al.  High Frequency and Intensity of Drinking may Attenuate Increased Inflammatory Cytokine Levels of Major Depression in Alcohol‐use Disorders , 2014, CNS neuroscience & therapeutics.

[73]  A. Araszkiewicz,et al.  The role of the neuroendocrine and immune systems in the pathogenesis of depression , 2014, Pharmacological reports : PR.

[74]  F. Carreño,et al.  Therapeutic Modalities for Treatment Resistant Depression: Focus on Vagal Nerve Stimulation and Ketamine , 2014, Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology.

[75]  Natalia Gulyaeva,et al.  Rodent Models of Depression: Neurotrophic and Neuroinflammatory Biomarkers , 2014, BioMed research international.

[76]  Sarah Spiegel,et al.  Sphingolipid metabolites in inflammatory disease , 2014, Nature.

[77]  Michael Maes,et al.  Oxidative/nitrosative stress and immuno-inflammatory pathways in depression: treatment implications. , 2014, Current pharmaceutical design.

[78]  A. Tamas,et al.  PACAP Protects Against Inflammatory-Mediated Toxicity in Dopaminergic SH-SY5Y Cells: Implication for Parkinson’s Disease , 2014, Neurotoxicity Research.

[79]  J. DiNicolantonio,et al.  Alcohol and cardiovascular health: the dose makes the poison…or the remedy. , 2014, Mayo Clinic proceedings.

[80]  R. Duman Pathophysiology of depression and innovative treatments: remodeling glutamatergic synaptic connections , 2014, Dialogues in clinical neuroscience.

[81]  M. Míguez-Burbano,et al.  Mood Disorders and BDNF Relationship with Alcohol Drinking Trajectories among PLWH Receiving Care , 2014, Journal of alcoholism and drug dependence.

[82]  N. Müller Immunology of Major Depression , 2014, Neuroimmunomodulation.

[83]  T. L. Briones,et al.  Chronic binge-like alcohol consumption in adolescence causes depression-like symptoms possibly mediated by the effects of BDNF on neurogenesis , 2013, Neuroscience.

[84]  B. Czéh,et al.  Talking to the synapse: how antidepressants can target glial cells to reshape brain circuits. , 2013, Current drug targets.

[85]  E. Castrén Neuronal network plasticity and recovery from depression. , 2013, JAMA psychiatry.

[86]  F. Lotrich,et al.  Inflammatory cytokines in depression: Neurobiological mechanisms and therapeutic implications , 2013, Neuroscience.

[87]  K. Carey,et al.  Alcohol use and cerebral white matter compromise in adolescence. , 2013, Addictive behaviors.

[88]  J. Kornhuber,et al.  Acid sphingomyelinase–ceramide system mediates effects of antidepressant drugs , 2013, Nature Medicine.

[89]  K. Bath,et al.  Stress effects on BDNF expression: Effects of age, sex, and form of stress , 2013, Neuroscience.

[90]  R. Taylor,et al.  Nicotine Blocks the Depressogenic Effects of Alcohol: Implications for Drinking-Smoking Co-Morbidity , 2013, Journal of drug and alcohol research.

[91]  L. Hurley,et al.  Neuroinflammation, Neurodegeneration, and Depression , 2013, Neurotoxicity Research.

[92]  D. Y. Lee,et al.  Alcohol and Cognition in the Elderly: A Review , 2012, Psychiatry investigation.

[93]  S. Hauser,et al.  Alcohol induced depressive-like behavior is associated with a reduction in hippocampal BDNF , 2011, Pharmacology Biochemistry and Behavior.

[94]  G. Schumann,et al.  Drugs' rapid payoffs distort evaluation of their instrumental uses 1 , 2011, Behavioral and Brain Sciences.

[95]  L. Bocchio-Chiavetto,et al.  Alterations of brain-derived neurotrophic factor serum levels in patients with alcohol dependence. , 2011, Alcoholism, clinical and experimental research.

[96]  Cai Song,et al.  Cytokines mediated inflammation and decreased neurogenesis in animal models of depression , 2011, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

[97]  R. Taylor,et al.  Toxic Effects of Low Alcohol and Nicotine Combinations in SH-SY5Y Cells are Apoptotically Mediated , 2011, Neurotoxicity Research.

[98]  J. Brust,et al.  Ethanol and Cognition: Indirect Effects, Neurotoxicity and Neuroprotection: A Review , 2010, International journal of environmental research and public health.

[99]  M. Maj,et al.  The inflammatory & neurodegenerative (I&ND) hypothesis of depression: leads for future research and new drug developments in depression , 2009, Metabolic Brain Disease.

[100]  F. Mouliere,et al.  Protective effect of BDNF against beta-amyloid induced neurotoxicity in vitro and in vivo in rats , 2008, Neurobiology of Disease.

[101]  P. Gressens,et al.  Neurotrophins and cytokines in neuronal plasticity. , 2008, Novartis Foundation symposium.

[102]  Margaret I Davis Ethanol-BDNF interactions: still more questions than answers. , 2008, Pharmacology & therapeutics.

[103]  S. Gold,et al.  Depression and immunity: inflammation and depressive symptoms in multiple sclerosis. , 2006, Neurologic clinics.

[104]  J. Kornhuber,et al.  High activity of acid sphingomyelinase in major depression , 2005, Journal of Neural Transmission.

[105]  Ramiro D. Almeida,et al.  Neuroprotection by BDNF against glutamate-induced apoptotic cell death is mediated by ERK and PI3-kinase pathways , 2005, Cell Death and Differentiation.

[106]  K. Takeda [Toll-like receptor]. , 2005, Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology.

[107]  C. Ehlers,et al.  Comorbidity of select anxiety and affective disorders with alcohol dependence in southwest California Indians. , 2004, Alcoholism, clinical and experimental research.

[108]  S. Belcher,et al.  Alterations of cerebellar mRNA specific for BDNF, p75NTR, and TrkB receptor isoforms occur within hours of ethanol administration to 4-day-old rat pups. , 2004, Brain research. Developmental brain research.

[109]  M. Naoi,et al.  Neuroprotective function of R-(-)-1-(benzofuran-2-yl)-2-propylaminopentane, [R-(-)-BPAP], against apoptosis induced by N-methyl(R)salsolinol, an endogenous dopaminergic neurotoxin, in human dopaminergic neuroblastoma SH-SY5Y cells. , 2004, Life sciences.

[110]  J. Grotta,et al.  Ethanol Plus Caffeine (Caffeinol) for Treatment of Ischemic Stroke: Preclinical Experience , 2003, Stroke.

[111]  B. Grant,et al.  Major depression in 6050 former drinkers: association with past alcohol dependence. , 2002, Archives of general psychiatry.

[112]  Johannes Schwarz,et al.  Selective dopaminergic neurotoxicity of isoquinoline derivatives related to Parkinson's disease: studies using heterologous expression systems of the dopamine transporter. , 2002, Biochemical pharmacology.

[113]  S. Rogers,et al.  Alcohol Blocks TNFα but Not Other Cytokine‐Mediated Neuroprotection to NMDA , 1999 .

[114]  Roberto Ciccocioppo,et al.  Antidepressant-like effect of ethanol revealed in the forced swimming test in Sardinian alcohol-preferring rats , 1999, Psychopharmacology.

[115]  M A Schuckit,et al.  Comparison of induced and independent major depressive disorders in 2,945 alcoholics. , 1997, The American journal of psychiatry.

[116]  E. Rimm,et al.  Review of moderate alcohol consumption and reduced risk of coronary heart disease: is the effect due to beer, wine, or spirits? , 1996, BMJ.

[117]  S. Renaud,et al.  Wine, alcohol, platelets, and the French paradox for coronary heart disease , 1992, The Lancet.

[118]  C. Baum-Baicker The psychological benefits of moderate alcohol consumption: a review of the literature. , 1985, Drug and alcohol dependence.

[119]  Bin Zhou,et al.  Molecular Substrates of Schizophrenia: Homeostatic Signaling to Connectivity , 2015, Molecular Psychiatry.

[120]  W. Mcbride,et al.  Ethanol-Associated Changes in Glutamate Reward Neurocircuitry: A Minireview of Clinical and Preclinical Genetic Findings. , 2016, Progress in molecular biology and translational science.

[121]  S. Appenzeller,et al.  The importance of cytokines and autoantibodies in depression. , 2015, Autoimmunity reviews.

[122]  F. Crews,et al.  Current hypotheses on the mechanisms of alcoholism. , 2014, Handbook of clinical neurology.

[123]  M. Schuckit,et al.  Genetics of Alcoholism , 1998, Science.

[124]  C. Parry,et al.  Chronic Diseases and Conditions Related to Alcohol Use , 2013, Alcohol research : current reviews.

[125]  Graeme Martin,et al.  Network analysis and the connectopathies: current research and future approaches. , 2012, Nonlinear dynamics, psychology, and life sciences.

[126]  L. Hurley,et al.  Positive and Negative Effects of Alcohol and Nicotine and Their Interactions: A Mechanistic Review , 2011, Neurotoxicity Research.

[127]  J. Kornhuber,et al.  Increased acid sphingomyelinase activity in peripheral blood cells of acutely intoxicated patients with alcohol dependence. , 2010, Alcoholism, clinical and experimental research.

[128]  M. Naoi,et al.  Dopamine-derived salsolinol derivatives as endogenous monoamine oxidase inhibitors: occurrence, metabolism and function in human brains. , 2004, Neurotoxicology.

[129]  R. Rosenheck,et al.  Comorbidity of Alcoholism and Psychiatric Disorders , 2002, Alcohol Research & Health.

[130]  R. Rosenheck,et al.  Comorbidity of Alcoholism and Psychiatric Disorders: An Overview , 2002 .

[131]  M. Thase,et al.  Comorbid alcoholism and depression: treatment issues. , 2001, The Journal of clinical psychiatry.