Block of T cell development in P53-deficient mice accelerates development of lymphomas with characteristic RAG-dependent cytogenetic alterations.

[1]  Ellen V Rothenberg,et al.  Molecular genetics of T cell development. , 2005, Annual review of immunology.

[2]  H. Kosugi-Okano,et al.  Involvement of V(D)J recombinase in the generation of intragenic deletions in the Rit1/Bcl11b tumor suppressor gene in gamma-ray-induced thymic lymphomas and in normal thymus of the mouse. , 2004, Carcinogenesis.

[3]  G. S. Lee,et al.  RAG Proteins Shepherd Double-Strand Breaks to a Specific Pathway, Suppressing Error-Prone Repair, but RAG Nicking Initiates Homologous Recombination , 2004, Cell.

[4]  M. Lieber,et al.  A non-B-DNA structure at the Bcl-2 major breakpoint region is cleaved by the RAG complex , 2004, Nature.

[5]  Jianzhu Chen,et al.  The T cell receptor β enhancer promotes access and pairing of Dβ and Jβ gene segments during V(D)J recombination , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[6]  M. Greaves,et al.  Origins of chromosome translocations in childhood leukaemia , 2003, Nature Reviews Cancer.

[7]  T. Ried,et al.  H2AX Haploinsufficiency Modifies Genomic Stability and Tumor Susceptibility , 2003, Cell.

[8]  F. Alt,et al.  Histone H2AX A Dosage-Dependent Suppressor of Oncogenic Translocations and Tumors , 2003, Cell.

[9]  M. Ciofani,et al.  Low Activation Threshold As a Mechanism for Ligand-Independent Signaling in Pre-T Cells 1 , 2003, The Journal of Immunology.

[10]  Toshiyuki Yamada,et al.  Molecular biology of the Ets family of transcription factors. , 2003, Gene.

[11]  J. Danska,et al.  The RAG-1/2 endonuclease causes genomic instability and controls CNS complications of lymphoblastic leukemia in p53/Prkdc-deficient mice. , 2003, Cancer cell.

[12]  Thomas Ried,et al.  Evidence for Replicative Repair of DNA Double-Strand Breaks Leading to Oncogenic Translocation and Gene Amplification , 2002, The Journal of experimental medicine.

[13]  C. Murre,et al.  Disruption of pre-TCR expression accelerates lymphomagenesis in E2A-deficient mice , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[14]  D. Hockenbery.  A mitochondrial Achilles' heel in cancer? , 2002, Cancer cell.

[15]  F. Alt,et al.  Unrepaired DNA Breaks in p53-Deficient Cells Lead to Oncogenic Gene Amplification Subsequent to Translocations , 2002, Cell.

[16]  F. Alt,et al.  The Mechanism and Regulation of Chromosomal V(D)J Recombination , 2002, Cell.

[17]  B. Nadel,et al.  V(D)J-mediated Translocations in Lymphoid Neoplasms , 2002, The Journal of experimental medicine.

[18]  J. Hoeijmakers,et al.  Chromosomal stability and the DNA double-stranded break connection , 2001, Nature Reviews Genetics.

[19]  K. Khanna,et al.  DNA double-strand breaks: signaling, repair and the cancer connection , 2001, Nature Genetics.

[20]  S. Knuutila,et al.  11q Deletions in Hematological Malignancies , 2001, Leukemia & lymphoma.

[21]  K. Tanaka,et al.  Restricted chromosome breakpoint sites on 11q22-q23.1 and 11q25 in various hematological malignancies without MLL/ALL-1 gene rearrangement. , 2001, Cancer genetics and cytogenetics.

[22]  S. Spicuglia,et al.  Chromatin Remodeling by the T Cell Receptor (Tcr)-β Gene Enhancer during Early T Cell Development , 2000, The Journal of Experimental Medicine.

[23]  F. Watrin,et al.  T Cell Development in TCRβ Enhancer-Deleted Mice: Implications for αβ T Cell Lineage Commitment and Differentiation1 , 2000, The Journal of Immunology.

[24]  F. Alt,et al.  DNA ligase IV deficiency in mice leads to defective neurogenesis and embryonic lethality via the p53 pathway. , 2000, Molecular cell.

[25]  F. Alt,et al.  Interplay of p53 and DNA-repair protein XRCC4 in tumorigenesis, genomic stability and development , 2000, Nature.

[26]  Thomas Ried,et al.  DNA repair protein Ku80 suppresses chromosomal aberrations and malignant transformation , 2000, Nature.

[27]  D. Schatz,et al.  The RAG proteins and V(D)J recombination: complexes, ends, and transposition. , 2000, Annual review of immunology.

[28]  D. Willerford,et al.  Regulated genomic instability and neoplasia in the lymphoid lineage. , 1999, Blood.

[29]  F. Alt,et al.  RAG2:GFP knockin mice reveal novel aspects of RAG2 expression in primary and peripheral lymphoid tissues. , 1999, Immunity.

[30]  A. Kruisbeek,et al.  Pre-TCR signaling and inactivation of p53 induces crucial cell survival pathways in pre-T cells. , 1999, Immunity.

[31]  Jianzhu Chen,et al.  Control of V(D)J Recombinational Accessibility of the Dβ1 Gene Segment at the TCRβ Locus by a Germline Promoter , 1999 .

[32]  C. Ling,et al.  Ku70: a candidate tumor suppressor gene for murine T cell lymphoma. , 1998, Molecular cell.

[33]  M. Qumsiyeh,et al.  No Requirement for V(D)J Recombination in p53-Deficient Thymic Lymphoma , 1998, Molecular and Cellular Biology.

[34]  T. Jacks,et al.  V(D)J recombination is not required for the development of lymphoma in p53-deficient mice. , 1998, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

[35]  R. Fleischmann,et al.  DNA-PKcs: a T-cell tumour suppressor encoded at the mouse scid locus , 1997, Nature Genetics.

[36]  F. Alt,et al.  Growth retardation and leaky SCID phenotype of Ku70-deficient mice. , 1997, Immunity.

[37]  M. James,et al.  Biallelic mutations in the ATM gene in T-prolymphocytic leukemia , 1997, Nature Medicine.

[38]  G. Chu.  Double Strand Break Repair* , 1997, The Journal of Biological Chemistry.

[39]  S. Lewis,et al.  Cryptic signals and the fidelity of V(D)J joining , 1997, Molecular and cellular biology.

[40]  J. Danska,et al.  Biochemical and genetic defects in the DNA-dependent protein kinase in murine scid lymphocytes , 1996, Molecular and cellular biology.

[41]  J. Danska,et al.  V(D)J recombination activates a p53-dependent DNA damage checkpoint in scid lymphocyte precursors. , 1996, Genes & development.

[42]  T. Jacks,et al.  Mutations in the p53 and SCID genes cooperate in tumorigenesis. , 1996, Genes & development.

[43]  F. Watrin,et al.  Deletion of the mouse T-cell receptor beta gene enhancer blocks alphabeta T-cell development. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[44]  M. Lenardo,et al.  p53 prevents maturation to the CD4+CD8+ stage of thymocyte differentiation in the absence of T cell receptor rearrangement , 1996, The Journal of experimental medicine.

[45]  K. Eichmann,et al.  Receptors and signals in early thymic selection. , 1995, Immunity.

[46]  Christina A. Cuomo,et al.  Cleavage at a V(D)J recombination signal requires only RAG1 and RAG2 proteins and occurs in two steps , 1995, Cell.

[47]  S. Tonegawa,et al.  Onset of TCR-beta gene rearrangement and role of TCR-beta expression during CD3-CD4-CD8- thymocyte differentiation. , 1994, Journal of immunology.

[48]  M J Owen,et al.  T cell receptor beta chain gene rearrangement and selection during thymocyte development in adult mice. , 1994, Immunity.

[49]  R. Weinberg,et al.  Tumor spectrum analysis in p53-mutant mice , 1994, Current Biology.

[50]  M. Schlissel,et al.  Double-strand signal sequence breaks in V(D)J recombination are blunt, 5'-phosphorylated, RAG-dependent, and cell cycle regulated. , 1993, Genes & development.

[51]  J. Menetski,et al.  V(D)J recombination: Broken DNA molecules with covalently sealed (hairpin) coding ends in scid mouse thymocytes , 1992, Cell.

[52]  W. Paul,et al.  Activation events during thymic selection , 1992, The Journal of experimental medicine.