Translational research in genomics of Alzheimer's disease: a review of current practice and future perspectives.
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W. M. van der Flier | A. Janssens | E. Hol | C. V. van Duijn | P. Heutink | S. Detmar | M. Rikkert | M. Cornel | Raluca Mihăescu | Cornelia M. van Duijna | Raluca Mihaescua | Symone B. Detmarb | Martina C. Cornelc | Wiesje M. van der Flierd | Peter Heutinke | Elly M. Holf | G. M. O. Rikkertg | Cecile J.W. Janssensa | Inga Zerr | Inga Zerr
[1] H. Schipper. Apolipoprotein E: Implications for AD neurobiology, epidemiology and risk assessment , 2011, Neurobiology of Aging.
[2] Brad J Kolls,et al. A PHASE 2 MULTIPLE ASCENDING DOSE TRIAL OF BAPINEUZUMAB IN MILD TO MODERATE ALZHEIMER DISEASE , 2010, Neurology.
[3] Nick C Fox,et al. A phase 2 multiple ascending dose trial of bapineuzumab in mild to moderate Alzheimer disease , 2009, Neurology.
[4] Robert Cook-Deegan,et al. Disclosure of APOE genotype for risk of Alzheimer's disease. , 2009, The New England journal of medicine.
[5] The Lancet Neurology. Genetic testing for disease susceptibility: a risky business , 2009, The Lancet Neurology.
[6] L. Costantini,et al. Study of the ketogenic agent AC-1202 in mild to moderate Alzheimer's disease: a randomized, double-blind, placebo-controlled, multicenter trial , 2009, Nutrition & metabolism.
[7] Alzheimer’s Association,et al. 2009 Alzheimer's disease facts and figures , 2009, Alzheimer's & Dementia.
[8] Jennifer Williamson,et al. Genetic Aspects of Alzheimer Disease , 2009, The neurologist.
[9] A. Burns. Alzheimer's disease: on the verges of treatment and prevention , 2009, The Lancet Neurology.
[10] V. Pankratz,et al. Genetic variation in PCDH11X is associated with susceptibility to late-onset Alzheimer's disease , 2009, Nature Genetics.
[11] Eden R Martin,et al. Genome-wide association study implicates a chromosome 12 risk locus for late-onset Alzheimer disease. , 2009, American journal of human genetics.
[12] S E Poduslo,et al. Genome screen of late‐onset Alzheimer's extended pedigrees identifies TRPC4AP by haplotype analysis , 2009, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.
[13] W. M. van der Flier,et al. CSF biomarkers in Alzheimer's disease and controls: associations with APOE genotype are modified by age. , 2009, Journal of Alzheimer's disease : JAD.
[14] Weixiong Zhang,et al. Integrating gene expression and phenotypic information to analyze Alzheimer's disease. , 2009, Journal of Alzheimer's disease : JAD.
[15] Christoph Lange,et al. Genome-wide association analysis reveals putative Alzheimer's disease susceptibility loci in addition to APOE. , 2008, American journal of human genetics.
[16] Peter Heutink,et al. Mutations in progranulin (GRN) within the spectrum of clinical and pathological phenotypes of frontotemporal dementia , 2008, The Lancet Neurology.
[17] Sven Cichon,et al. A genome-wide association study for late-onset Alzheimer's disease using DNA pooling , 2008, BMC Medical Genomics.
[18] D. Swaab,et al. Hippocampal Estrogen Receptor-Alpha Splice Variant TADDI in the Human Brain in Aging and Alzheimer’s Disease , 2008, Neuroendocrinology.
[19] R. Kukreti,et al. Pharmacogenomics and treatment for dementia induced by Alzheimer's disease. , 2008, Pharmacogenomics.
[20] D. Holtzman,et al. Active and passive immunotherapy for neurodegenerative disorders. , 2008, Annual review of neuroscience.
[21] Dick F Swaab,et al. Effect of bright light and melatonin on cognitive and noncognitive function in elderly residents of group care facilities: a randomized controlled trial. , 2008, JAMA.
[22] M. O. Olde Rikkert,et al. Consensus Statement on Genetic Research in Dementia , 2008, American journal of Alzheimer's disease and other dementias.
[23] H. Soininen,et al. Development of Screening Guidelines and Clinical Criteria for Predementia Alzheimer’s Disease , 2008, Neuroepidemiology.
[24] Laura Bonetta. Getting Up Close and Personal with Your Genome , 2008, Cell.
[25] Richard J. Caselli,et al. Cholesterol-related genetic risk scores are associated with hypometabolism in Alzheimer's-affected brain regions , 2008, NeuroImage.
[26] Andrew Kertesz,et al. Diagnosis and treatment of dementia: 2. Diagnosis , 2008, Canadian Medical Association Journal.
[27] B. Winblad,et al. Apolipoprotein E ε4 magnifies lifestyle risks for dementia: a population-based study , 2008, Journal of cellular and molecular medicine.
[28] Robert Cook-Deegan,et al. Incorporating ethnicity into genetic risk assessment for Alzheimer disease: the REVEAL study experience , 2008, Genetics in Medicine.
[29] Roger N Rosenberg,et al. Genome-wide association studies in Alzheimer disease. , 2008, Archives of neurology.
[30] C. Patterson,et al. Diagnosis and treatment of dementia: 1. Risk assessment and primary prevention of Alzheimer disease , 2008, Canadian Medical Association Journal.
[31] M. Khoury,et al. A navigator for human genome epidemiology , 2008, Nature Genetics.
[32] K. Ritchie,et al. Hormonal treatment, mild cognitive impairment and Alzheimer's disease , 2008, International Psychogeriatrics.
[33] M. Rikkert,et al. Genetic research into Alzheimer's Disease: a European focus group study on ethical issues , 2008, International journal of geriatric psychiatry.
[34] H. Chertkow. Diagnosis and treatment of dementia: Introduction. Introducing a series based on the Third Canadian Consensus Conference on the Diagnosis and Treatment of Dementia , 2007, Canadian Medical Association Journal.
[35] P. Bria,et al. Is Alzheimer's disease a synaptic disorder? , 2008, Journal of Alzheimer's disease : JAD.
[36] Brenda Wilson,et al. A systematic review of perceived risks, psychological and behavioral impacts of genetic testing , 2008, Genetics in Medicine.
[37] S. Poduslo,et al. Cluster Analysis of Risk Factor Genetic Polymorphisms in Alzheimer’s Disease , 2008, Neurochemical Research.
[38] A. J. Slater,et al. Candidate single-nucleotide polymorphisms from a genomewide association study of Alzheimer disease. , 2008, Archives of neurology.
[39] R. Cacabelos. Pharmacogenomics and therapeutic prospects in dementia , 2008, European Archives of Psychiatry and Clinical Neuroscience.
[40] C. Caruso,et al. Alzheimer's disease and genetics of inflammation: a pharmacogenomic vision. , 2007, Pharmacogenomics.
[41] E. Corder,et al. Genetic risk profiles for Alzheimer's disease: Integration of APOE genotype and variants that up-regulate inflammation , 2007, Neurobiology of Aging.
[42] Rebecca F. Halperin,et al. Sorl1 as an Alzheimer’s Disease Predisposition Gene? , 2007, Neurodegenerative Diseases.
[43] M. Khoury,et al. The continuum of translation research in genomic medicine: how can we accelerate the appropriate integration of human genome discoveries into health care and disease prevention? , 2007, Genetics in Medicine.
[44] A. Sadovnick,et al. Genetics and dementia: Risk factors, diagnosis, and management , 2007, Alzheimer's & Dementia.
[45] Bernardino Ghetti,et al. The Genetics of Very Early Onset Alzheimer Disease , 2007, Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology.
[46] L. Bäckman,et al. Cognitive deficits in preclinical Alzheimer's disease and vascular dementia: Patterns of findings from the Kungsholmen Project , 2007, Physiology & Behavior.
[47] Ewout W Steyerberg,et al. The impact of genotype frequencies on the clinical validity of genomic profiling for predicting common chronic diseases , 2007, Genetics in Medicine.
[48] Martin Klein,et al. Cognitive Impairment in Alzheimer’s Disease Is Modified by APOE Genotype , 2007, Dementia and Geriatric Cognitive Disorders.
[49] Winnie S. Liang,et al. GAB2 Alleles Modify Alzheimer's Risk in APOE ɛ4 Carriers , 2007, Neuron.
[50] R. Mayeux,et al. Genetic research and genetic testing in Alzheimer's disease: a view from the bridge , 2007, Nature Clinical Practice Neurology.
[51] Rebecca F. Halperin,et al. A high-density whole-genome association study reveals that APOE is the major susceptibility gene for sporadic late-onset Alzheimer's disease. , 2007, The Journal of clinical psychiatry.
[52] M. Gill,et al. Evidence for novel susceptibility genes for late-onset Alzheimer's disease from a genome-wide association study of putative functional variants. , 2007, Human molecular genetics.
[53] B. Borroni,et al. The effect of APOE genotype on clinical phenotype in Alzheimer disease , 2007, Neurology.
[54] F. Licastro,et al. Polymorphisms of pro-inflammatory genes and Alzheimer's disease risk: A pharmacogenomic approach , 2007, Mechanisms of Ageing and Development.
[55] P. Scheltens,et al. Recommendations for the diagnosis and management of Alzheimer's disease and other disorders associated with dementia: EFNS guideline , 2007, European journal of neurology.
[56] Philip Thomas,et al. A review of genome mutation and Alzheimer's disease. , 2006, Mutagenesis.
[57] D. Blacker,et al. Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database , 2007, Nature Genetics.
[58] Alessandro Serretti,et al. Genetics of Alzheimer's disease. A rapidly evolving field. , 2007, Journal of Alzheimer's disease : JAD.
[59] Winnie S. Liang,et al. GAB2 alleles modify Alzheimer's risk in APOE epsilon4 carriers. , 2007, Neuron.
[60] E. Reiman,et al. Alzheimer's disease a century later. , 2006, The Journal of clinical psychiatry.
[61] Colin L Masters,et al. Alzheimer's centennial legacy: prospects for rational therapeutic intervention targeting the Abeta amyloid pathway. , 2006, Brain : a journal of neurology.
[62] G. Small. Diagnostic Issues in Dementia: Neuroimaging as a Surrogate Marker of Disease , 2006, Journal of geriatric psychiatry and neurology.
[63] E. Porcellini,et al. Impaired regulation of immune responses in cognitive decline and Alzheimer’s disease: lessons from genetic association studies , 2006, Expert review of neurotherapeutics.
[64] A D Roses,et al. Efficacy of rosiglitazone in a genetically defined population with mild-to-moderate Alzheimer's disease , 2006, The Pharmacogenomics Journal.
[65] Ewout W Steyerberg,et al. Predictive testing for complex diseases using multiple genes: Fact or fiction? , 2006, Genetics in Medicine.
[66] E. Corder,et al. Membership in genetic groups predicts Alzheimer disease. , 2006, Rejuvenation research.
[67] Joel Gelernter,et al. Variation at APOE and STH loci and Alzheimer's disease , 2006, Behavioral and Brain Functions.
[68] L. Fratiglioni,et al. Role of genes and environments for explaining Alzheimer disease. , 2006, Archives of general psychiatry.
[69] C. Mathers,et al. Global prevalence of dementia: a Delphi consensus study , 2005, The Lancet.
[70] L. Schneider,et al. Memantine for dementia. , 2006, The Cochrane database of systematic reviews.
[71] Robert C Green,et al. Genetic Risk Assessment for Adult Children of People With Alzheimer’s Disease: The Risk Evaluation and Education for Alzheimer’s Disease (REVEAL) Study , 2005, Journal of geriatric psychiatry and neurology.
[72] W. M. van der Flier,et al. Epidemiology and risk factors of dementia , 2005, Journal of Neurology, Neurosurgery & Psychiatry.
[73] Andreas Papassotiropoulos,et al. A cluster of cholesterol-related genes confers susceptibility for Alzheimer's disease. , 2005, The Journal of clinical psychiatry.
[74] R. Mayeux,et al. Predictive utility of apolipoprotein E genotype for Alzheimer disease in outpatients with mild cognitive impairment. , 2005, Archives of neurology.
[75] D. Murphy,et al. The Women's Health Initiative Memory Study: findings and implications for treatment , 2005, The Lancet Neurology.
[76] F. Sherriff,et al. Memantine for dementia. , 2005, The Cochrane database of systematic reviews.
[77] R. Green,et al. Estimating risk curves for first-degree relatives of patients with Alzheimer’s disease: The REVEAL study , 2004, Genetics in Medicine.
[78] J. Raftery,et al. Long-term donepezil treatment in 565 patients with Alzheimer's disease (AD2000): randomised double-blind trial , 2004, The Lancet.
[79] M. Spriggs. Genetically selected baby free of inherited predisposition to early-onset Alzheimer’s disease , 2002, Journal of medical ethics.
[80] S. Rechitsky,et al. Preimplantation diagnosis for early-onset Alzheimer disease caused by V717L mutation. , 2002, JAMA.
[81] R. Green,et al. Risk of dementia among white and African American relatives of patients with Alzheimer disease. , 2002, JAMA.
[82] A. Hofman,et al. Prevalence of dementia and major subtypes in Europe: A collaborative study of population-based cohorts. Neurologic Diseases in the Elderly Research Group. , 2000, Neurology.
[83] A. Hofman,et al. Incidence of dementia and major subtypes in Europe: A collaborative study of population-based cohorts. Neurologic Diseases in the Elderly Research Group. , 2000, Neurology.
[84] E. Mandelkow,et al. Tau in Alzheimer's disease. , 1998, Trends in cell biology.
[85] A D Roses,et al. Utility of the apolipoprotein E genotype in the diagnosis of Alzheimer's disease. Alzheimer's Disease Centers Consortium on Apolipoprotein E and Alzheimer's Disease. , 1998, The New England journal of medicine.
[86] J. Haines,et al. Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium. , 1997, JAMA.
[87] A. Roses,et al. The clinical introduction of genetic testing for Alzheimer disease. An ethical perspective. , 1997, JAMA.
[88] S. Faraone,et al. Review Article: Genetics of Alzheimer Disease , 2010, Journal of geriatric psychiatry and neurology.
[89] J. Rommens,et al. Alzheimer's disease associated with mutations in presenilin 2 is rare and variably penetrant. , 1996, Human molecular genetics.
[90] J. Rommens,et al. Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene , 1995, Nature.
[91] G. Schellenberg,et al. Candidate gene for the chromosome 1 familial Alzheimer's disease locus , 1995, Science.
[92] D. Pollen,et al. Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease , 1995, Nature.
[93] J. Haines,et al. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. , 1993, Science.
[94] M A Pericak-Vance,et al. Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer's disease. , 1993, Neurology.
[95] M. Pericak-Vance,et al. Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease , 1991, Nature.
[96] A. Hofman,et al. Familial aggregation of Alzheimer's disease and related disorders: a collaborative re-analysis of case-control studies. , 1991, International journal of epidemiology.