Trinucleotide repeat DNA structures: dynamic mutations from dynamic DNA.

[1]  E. Bradbury,et al.  GAA instability in Friedreich's Ataxia shares a common, DNA-directed and intraallelic mechanism with other trinucleotide diseases. , 1998, Molecular cell.

[2]  E. Eichler,et al.  Interruptions in the triplet repeats of SCA1 and FRAXA reduce the propensity and complexity of slipped strand DNA (S-DNA) formation. , 1998, Biochemistry.

[3]  R. Sinden,et al.  Structural analysis of slipped-strand DNA (S-DNA) formed in (CTG)n. (CAG)n repeats from the myotonic dystrophy locus. , 1998, Nucleic acids research.

[4]  R. Sinden,et al.  CTG repeats associated with human genetic disease are inherently flexible. , 1998, Journal of molecular biology.

[5]  D. Leach,et al.  Evidence for two preferred hairpin folding patterns in d(CGG).d(CCG) repeat tracts in vivo. , 1998, Journal of Molecular Biology.

[6]  S. Mirkin,et al.  Trinucleotide repeats affect DNA replication in vivo , 1997, Nature Genetics.

[7]  S C Harvey,et al.  Flexible DNA: Genetically Unstable CTG·CAG and CGG·CCG from Human Hereditary Neuromuscular Disease Genes* , 1997, The Journal of Biological Chemistry.

[8]  R. Wells,et al.  Hairpin Formation during DNA Synthesis Primer Realignmentin Vitro in Triplet Repeat Sequences from Human Hereditary Disease Genes* , 1997, The Journal of Biological Chemistry.

[9]  R. Sinden,et al.  Human MSH2 binds to trinucleotide repeat DNA structures associated with neurodegenerative diseases. , 1997, Human molecular genetics.

[10]  J. Miret,et al.  Instability of CAG and CTG trinucleotide repeats in Saccharomyces cerevisiae , 1997, Molecular and cellular biology.

[11]  J. Stavenhagen,et al.  Stability of a CTG/CAG trinucleotide repeat in yeast is dependent on its orientation in the genome , 1997, Molecular and cellular biology.

[12]  I. Haworth,et al.  At physiological pH, d(CCG)15 forms a hairpin containing protonated cytosines and a distorted helix. , 1997, Biochemistry.

[13]  D. Livingston,et al.  Destabilization of CAG trinucleotide repeat tracts by mismatch repair mutations in yeast. , 1997, Human molecular genetics.

[14]  D. Livingston,et al.  Orientation dependence of trinucleotide CAG repeat instability in Saccharomyces cerevisiae , 1996, Molecular and cellular biology.

[15]  M. Zheng,et al.  Genetically unstable CXG repeats are structurally dynamic and have a high propensity for folding. An NMR and UV spectroscopic study. , 1996, Journal of molecular biology.

[16]  R. Gellibolian,et al.  Long CCG triplet repeat blocks exclude nucleosomes: a possible mechanism for the nature of fragile sites in chromosomes. , 1996, Journal of molecular biology.

[17]  A. Wolffe,et al.  Nucleosome Assembly on Methylated CGG Triplet Repeats in the Fragile X Mental Retardation Gene 1 Promoter* , 1996, The Journal of Biological Chemistry.

[18]  J. Griffith,et al.  Methylation of Expanded CCG Triplet Repeat DNA from Fragile X Syndrome Patients Enhances Nucleosome Exclusion* , 1996, The Journal of Biological Chemistry.

[19]  R. Sinden,et al.  Single-stranded DNA-binding protein enhances the stability of CTG triplet repeats in Escherichia coli , 1996, Journal of bacteriology.

[20]  R. Wells,et al.  Cloning, Characterization, and Properties of Seven Triplet Repeat DNA Sequences* , 1996, The Journal of Biological Chemistry.

[21]  A. Wolffe,et al.  Nucleosome Assembly on CTG Triplet Repeats* , 1996, The Journal of Biological Chemistry.

[22]  Myron F. Goodman,et al.  Gene Targeting in Rat Embryo Fibroblasts Promoted by the Polyomavirus Large T Antigen Associated With Neurological Diseases , 1996 .

[23]  R. Sinden,et al.  Alternative structures in duplex DNA formed within the trinucleotide repeats of the myotonic dystrophy and fragile X loci. , 1996, Biochemistry.

[24]  S. Mariappan,et al.  Structure and dynamics of the DNA hairpins formed by tandemly repeated CTG triplets associated with myotonic dystrophy. , 1996, Nucleic acids research.

[25]  R. Moyzis,et al.  Solution structures of the individual single strands of the fragile X DNA triplets (GCC)n.(GGC)n. , 1996, Nucleic acids research.

[26]  E. Eichler,et al.  Anomalous rapid electrophoretic mobility of DNA containing triplet repeats associated with human disease genes. , 1995, Biochemistry.

[27]  D. Patel,et al.  Solution structure of a DNA quadruplex containing the fragile X syndrome triplet repeat. , 1995, Journal of molecular biology.

[28]  M. Fry,et al.  The Fragile X Syndrome Single Strand d(CGG)n Nucleotide Repeats Readily Fold Back to Form Unimolecular Hairpin Structures * , 1995, The Journal of Biological Chemistry.

[29]  R. Sinden,et al.  Mismatch repair in Escherichia coli enhances instability of (CTG)n triplet repeats from human hereditary diseases. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[30]  M. Mitas,et al.  The purine-rich trinucleotide repeat sequences d(CAG)15 and d(GAC)15 form hairpins. , 1995, Nucleic acids research.

[31]  K. Woodford,et al.  CGG repeats associated with DNA instability and chromosome fragility form structures that block DNA synthesis in vitro. , 1995, Nucleic acids research.

[32]  I. Haworth,et al.  The trinucleotide repeat sequence d(CGG)15 forms a heat-stable hairpin containing Gsyn. Ganti base pairs. , 1995, Biochemistry.

[33]  Xiaolian Gao,et al.  New Antiparallel Duplex Motif of DNA CCG Repeats That Is Stabilized by Extrahelical Bases Symmetrically Located in the Minor Groove , 1995 .

[34]  I. Haworth,et al.  The trinucleotide repeat sequence d(GTC)15 adopts a hairpin conformation. , 1995, Nucleic acids research.

[35]  J. Mitchell,et al.  Compact structures of d(CNG)n oligonucleotides in solution and their possible relevance to fragile X and related human genetic diseases. , 1995, Nucleic acids research.

[36]  Keiichi Ohshima,et al.  Expansion and deletion of CTG repeats from human disease genes are determined by the direction of replication in E. coli , 1995, Nature Genetics.

[37]  S. S. Smith,et al.  Hairpins are formed by the single DNA strands of the fragile X triplet repeats: structure and biological implications. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[38]  A. Marquis Gacy,et al.  Trinucleotide repeats that expand in human disease form hairpin structures in vitro , 1995, Cell.

[39]  T. Kamp,et al.  Hairpin properties of single-stranded DNA containing a GC-rich triplet repeat: (CTG)15. , 1995, Nucleic acids research.

[40]  J. Griffith,et al.  Expanded CTG triplet blocks from the myotonic dystrophy gene create the strongest known natural nucleosome positioning elements. , 1995, Genomics.

[41]  R. Sinden.  DNA Structure and Function , 1994 .

[42]  R. Wells,et al.  Preferential nucleosome assembly at DNA triplet repeats from the myotonic dystrophy gene. , 1994, Science.

[43]  L. Loeb,et al.  The fragile X syndrome d(CGG)n nucleotide repeats form a stable tetrahelical structure. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[44]  H. Wang,et al.  A single trinucleotide, 5'AGC3'/5'GCT3', of the triplet-repeat disease genes confers metal ion-induced non-B DNA structure. , 1993, Nucleic acids research.

[45]  D. Lilley,et al.  The structure of branched DNA species , 1993, Quarterly Reviews of Biophysics.

[46]  Robert I. Richards,et al.  Dynamic mutations: A new class of mutations causing human disease , 1992, Cell.

[47]  R. Richards,et al.  Heritable unstable DNA sequences , 1992, Nature Genetics.

[48]  D. Crothers,et al.  Effects of DNA sequence and histone-histone interactions on nucleosome placement. , 1990, Journal of molecular biology.

[49]  B. Zimm,et al.  Understanding the anomalous electrophoresis of bent DNA molecules: a reptation model. , 1989, Science.

[50]  M. Eisenstein,et al.  Structures of the mismatched duplex d(GGGTGCCC) and one of its Watson-Crick analogues d(GGGCGCCC). , 1988, Journal of molecular biology.

[51]  P. Patel,et al.  The GAA triplet-repeat expansion in Friedreich ataxia interferes with transcription and may be associated with an unusual DNA structure. , 1998, American journal of human genetics.

[52]  S. Warren,et al.  Genetic instabilities and hereditary neurological diseases , 1998 .

[53]  N. Arnheim,et al.  Stability of intrastrand hairpin structures formed by the CAG/CTG class of DNA triplet repeats associated with neurological diseases. , 1996, Nucleic acids research.

[54]  R. Sinden,et al.  Erratum: Single-stranded DNA-binding protein enhances the stability of CTG triplet repeats in Escherichia coli (Journal of Bacteriology 178:16 (5042)) , 1996 .

[55]  G. Fox,et al.  DNA CTG triplet repeats involved in dynamic mutations of neurologically related gene sequences form stable duplexes. , 1995, Nucleic acids research.