Source estimation of epileptic activity using eLORETA kurtosis analysis

Exact low-resolution brain electromagnetic tomography (eLORETA) is a technique for three-dimensional representation of the distribution of sources of electrical activity in the brain. Kurtosis analysis allows for identification of spiky activity in the brain. To evaluate the reliability of eLORETA kurtosis analysis, the results of the analysis were compared with those of equivalent current dipole (ECD) and synthetic aperture magnetometry (SAM) kurtosis analysis of magnetoencephalography (MEG) data in a patient with epilepsy with elementary visual seizures in a 6-year follow-up. The results of electroencephalography (EEG) eLORETA kurtosis analysis indicative of a right superior temporal spike source partially overlapped with MEG ECD/SAM kurtosis results in all recordings, with a total overlapping at the end of the follow-up period. Overall findings suggest that eLORETA kurtosis analysis of EEG data may aid in the localisation of spike activity sources in patients with epilepsy.

[1]  Interictal spikes in the fusiform and inferior temporal gyri of an epileptic patient with colored elementary visual auras: a 5-year longitudinal MEG ECD study , 2003, Neuroreport.

[2]  H. E. Kirsch,et al.  Automated localization of magnetoencephalographic interictal spikes by adaptive spatial filtering , 2006, Clinical Neurophysiology.

[3]  S Ukai,et al.  SAM(g2) analysis for detecting spike localization: a comparison with clinical symptoms and ECD analysis in an epileptic patient. , 2004, Neurology & clinical neurophysiology : NCN.

[4]  R. Pascual-Marqui,et al.  Resting-State EEG Source Localization and Functional Connectivity in Schizophrenia-Like Psychosis of Epilepsy , 2011, PloS one.

[5]  C. Panayiotopoulos.  Elementary visual hallucinations, blindness, and headache in idiopathic occipital epilepsy: differentiation from migraine , 1999, Journal of neurology, neurosurgery, and psychiatry.

[6]  D. Lehmann,et al.  Low resolution electromagnetic tomography: a new method for localizing electrical activity in the brain. , 1994, International journal of psychophysiology : official journal of the International Organization of Psychophysiology.

[7]  Masao Iwase,et al.  Cephalic auras of supplementary motor area origin: An ictal MEG and SAM(g2) study , 2008, Epilepsy & Behavior.

[8]  Ayako Ochi,et al.  Spatially filtered magnetoencephalography compared with electrocorticography to identify intrinsically epileptogenic focal cortical dysplasia , 2008, Epilepsy Research.

[9]  H. Otsubo,et al.  Ictal magnetoencephalographic discharges from elementary visual hallucinations of status epilepticus , 2003, Journal of neurology, neurosurgery, and psychiatry.

[10]  Masao Iwase,et al.  Association of cerebrospinal fluid tap‐related oscillatory activity and shunt outcome in idiopathic normal‐pressure hydrocephalus , 2015, Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society.

[11]  R. Pascual-Marqui,et al.  Detection of EEG-resting state independent networks by eLORETA-ICA method , 2015, Front. Hum. Neurosci..

[12]  Ayako Ochi,et al.  Localization of epileptic foci in children with intractable epilepsy secondary to multiple cortical tubers by using synthetic aperture magnetometry kurtosis. , 2009, Journal of neurosurgery. Pediatrics.

[13]  池田 俊一郎.  Association of cerebrospinal fluid tap-related oscillatory activity and shunt outcome in idiopathic normal-pressure hydrocephalus , 2015 .

[14]  R. Pascual-Marqui,et al.  Functional connectivity assessed by resting state EEG correlates with cognitive decline of Alzheimer’s disease – An eLORETA study , 2016, Clinical Neurophysiology.