Organic nitrogen of tomato waste hydrolysate enhances glucose uptake and lipid accumulation in Cunninghamella echinulata

Aims:  To investigate the effect of organic nitrogen on lipogenesis during growth of Cunninghamella echinulata on tomato waste hydrolysate (TWH) media.

[1]  Colin Ratledge,et al.  Fatty acid biosynthesis in microorganisms being used for Single Cell Oil production. , 2004, Biochimie.

[2]  G. Eggink,et al.  High-cell-density cultivation of the lipid accumulating yeast Cryptococcus curvatus using glycerol as a carbon source , 1996, Applied Microbiology and Biotechnology.

[3]  S. Papanikolaou,et al.  Biotechnological valorisation of raw glycerol discharged after bio-diesel (fatty acid methyl esters) manufacturing process: Production of 1,3-propanediol, citric acid and single cell oil , 2008 .

[4]  M. Komaitis,et al.  Production of γ-linolenic acid by Cunninghamella echinulata cultivated on glucose and orange peel , 2002, Applied Microbiology and Biotechnology.

[5]  Hung-Chang Chen,et al.  Production of γ‐Linolenic Acid by the Fungus Cunninghamella echinulata CCRC 31840 , 1996 .

[6]  G. Aggelis,et al.  Prediction of lipid accumulation-degradation in oleaginous micro-organisms growing on vegetable oils , 1997, Antonie van Leeuwenhoek.

[7]  E. Park,et al.  Effect of consumed carbon to nitrogen ratio of mycelial morphology and arachidonic acid production in cultures of Mortierella alpina. , 2001, Journal of bioscience and bioengineering.

[8]  S. Papanikolaou,et al.  Lipids of Cunninghamella echinulata with emphasis to γ-linolenic acid distribution among lipid classes , 2006, Applied Microbiology and Biotechnology.

[9]  C. Gallert,et al.  Solid and liquid residues as raw materials for biotechnology , 2002, Naturwissenschaften.

[10]  I. Ellis,et al.  Gamma linolenic acid with tamoxifen as primary therapy in breast cancer , 1998, International journal of cancer.

[11]  U. Das From bench to the clinic: gamma-linolenic acid therapy of human gliomas. , 2004, Prostaglandins, leukotrienes, and essential fatty acids.

[12]  Y. Kamisaka,et al.  Incorporation of linoleic acid and its conversion to λ-linolenic acid in fungi , 2007, Lipids.

[13]  Seraphim Papanikolaou,et al.  Lipid production by oleaginous Mucorales cultivated on renewable carbon sources , 2007 .

[14]  L. H. Stickland The determination of small quantities of bacteria by means of the biuret reaction. , 1951, Journal of general microbiology.

[15]  U. Das From bench to the clinic: γ-linolenic acid therapy of human gliomas , 2004 .

[16]  S. Papanikolaou,et al.  Gamma-linolenic acid production by Cunninghamella echinulata growing on complex organic nitrogen sources. , 2008, Bioresource technology.

[17]  C. Ratledge,et al.  The biochemistry and molecular biology of lipid accumulation in oleaginous microorganisms. , 2002, Advances in applied microbiology.

[18]  A. Bories,et al.  Glycerol inhibition of growth and dihydroxyacetone production byGluconobacter oxydans , 1992, Current Microbiology.

[19]  G. L. Miller Use of Dinitrosalicylic Acid Reagent for Determination of Reducing Sugar , 1959 .

[20]  J. Folch,et al.  A simple method for the isolation and purification of total lipides from animal tissues. , 1957, The Journal of biological chemistry.

[21]  S. Papanikolaou,et al.  Repression of reserve lipid turnover in Cunninghamella echinulata and Mortierella isabellina cultivated in multiple‐limited media , 2004, Journal of applied microbiology.

[22]  M. Kennedy,et al.  Fatty acid production characteristics of fungi with particular emphasis on gamma linolenic acid production , 1993, Biotechnology and bioengineering.

[23]  Seraphim Papanikolaou,et al.  Compositional shifts in lipid fractions during lipid turnover in Cunninghamella echinulata , 2007 .

[24]  T. Antczak,et al.  Relationships between lipases and lipids in mycelia of two Mucor strains , 2006 .

[25]  C. T. Evans,et al.  Effect of Nitrogen Source on Lipid Accumulation in Oleaginous Yeasts , 1984 .

[26]  Hung-Chang Chen,et al.  Inoculum effects on the production of γ-linolenic acid by the shake culture of Cunninghamella echinulata CCRC 31840 , 1997 .

[27]  J. Romans α-LINOLENIC ACID , 1989, The Lancet.

[28]  Craig Frear,et al.  A laboratory study of producing docosahexaenoic acid from biodiesel-waste glycerol by microalgal fermentation , 2007 .

[29]  M. Komaitis,et al.  Lipid and γ-linolenic acid accumulation in strains of zygomycetes growing on glucose , 2001 .

[30]  C Ratledge,et al.  Biochemical events leading to the diversion of carbon into storage lipids in the oleaginous fungi Mucor circinelloides and Mortierella alpina. , 2001, Microbiology.

[31]  M. Čertík,et al.  Effect of nitrogen sources on the activities of lipogenic enzymes in oleaginous fungus Cunninghamella echinulata. , 1999, The Journal of general and applied microbiology.