Tet3 Reads 5-Carboxylcytosine through Its CXXC Domain and Is a Potential Guardian against Neurodegeneration.

[1]  G. Rouleau,et al.  Genetic perspective on the role of the autophagy-lysosome pathway in Parkinson disease , 2015, Autophagy.

[2]  M. Biel,et al.  TET3 is recruited by REST for context-specific hydroxymethylation and induction of gene expression. , 2015, Cell reports.

[3]  Mark J. S. Kelly,et al.  Histone demethylase KDM5A is regulated by its reader domain through a positive-feedback mechanism , 2015, Nature Communications.

[4]  She Chen,et al.  Recognition of H3K9 methylation by GLP is required for efficient establishment of H3K9 methylation, rapid target gene repression, and mouse viability , 2015, Genes & development.

[5]  Chuan He,et al.  Base-resolution maps of 5-formylcytosine and 5-carboxylcytosine reveal genome-wide DNA demethylation dynamics , 2015, Cell Research.

[6]  J. Yates,et al.  Product Binding Enforces the Genomic Specificity of a Yeast Polycomb Repressive Complex , 2015, Cell.

[7]  J. Marioni,et al.  Genome-wide Bisulfite Sequencing in Zygotes Identifies Demethylation Targets and Maps the Contribution of TET3 Oxidation , 2014, Cell reports.

[8]  G. Pfeifer,et al.  5-Hydroxymethylcytosine: a stable or transient DNA modification? , 2014, Genomics.

[9]  Jin He,et al.  Tet3 and DNA replication mediate demethylation of both the maternal and paternal genomes in mouse zygotes. , 2014, Cell stem cell.

[10]  Lu Wen,et al.  Active and passive demethylation of male and female pronuclear DNA in the mammalian zygote. , 2014, Cell stem cell.

[11]  S. Gygi,et al.  iPSC-derived neurons from GBA1-associated Parkinson’s disease patients show autophagic defects and impaired calcium homeostasis , 2014, Nature Communications.

[12]  M. Matunis,et al.  E2-mediated Small Ubiquitin-like Modifier (SUMO) Modification of Thymine DNA Glycosylase Is Efficient but Not Selective for the Enzyme-Product Complex* , 2014, The Journal of Biological Chemistry.

[13]  W. Liu,et al.  Tet and TDG mediate DNA demethylation essential for mesenchymal-to-epithelial transition in somatic cell reprogramming. , 2014, Cell stem cell.

[14]  Ruiqiang Li,et al.  Whole-genome analysis of 5-hydroxymethylcytosine and 5-methylcytosine at base resolution in the human brain , 2014, Genome Biology.

[15]  M. Groudine,et al.  The histone-H3K4-specific demethylase KDM5B binds to its substrate and product through distinct PHD fingers. , 2014, Cell reports.

[16]  Hao Wu,et al.  Reversing DNA Methylation: Mechanisms, Genomics, and Biological Functions , 2014, Cell.

[17]  William A. Pastor,et al.  Distinct roles of the methylcytosine oxidases Tet1 and Tet2 in mouse embryonic stem cells , 2014, Proceedings of the National Academy of Sciences.

[18]  Xing Zhang,et al.  Structure of a Naegleria Tet-like dioxygenase in complex with 5-methylcytosine DNA , 2013, Nature.

[19]  Ze Li,et al.  Crystal Structure of TET2-DNA Complex: Insight into TET-Mediated 5mC Oxidation , 2013, Cell.

[20]  Yuting Liu,et al.  Role of Tet1 in erasure of genomic imprinting , 2013, Nature.

[21]  Zechen Chong,et al.  Ascorbic acid enhances Tet-mediated 5-methylcytosine oxidation and promotes DNA demethylation in mammals. , 2013, Journal of the American Chemical Society.

[22]  Xiaodong Cheng,et al.  Activity and crystal structure of human thymine DNA glycosylase mutant N140A with 5-carboxylcytosine DNA at low pH. , 2013, DNA repair.

[23]  Mohammad M. Karimi,et al.  Vitamin C induces Tet-dependent DNA demethylation and a blastocyst-like state in ES cells , 2013, Nature.

[24]  Heinrich Leonhardt,et al.  Intrinsic and Extrinsic Connections of Tet3 Dioxygenase with CXXC Zinc Finger Modules , 2013, PloS one.

[25]  Hongjun Song,et al.  Quantitative assessment of Tet-induced oxidation products of 5-methylcytosine in cellular and tissue DNA , 2013, Nucleic acids research.

[26]  Swati Kadam,et al.  5-hydroxymethylcytosine and its potential roles in development and cancer , 2013, Epigenetics & Chromatin.

[27]  Yi Zhang,et al.  Genome-wide Analysis Reveals TET- and TDG-Dependent 5-Methylcytosine Oxidation Dynamics , 2013, Cell.

[28]  L. Aravind,et al.  Modulation of TET2 expression and 5-methylcytosine oxidation by the CXXC domain protein IDAX , 2013, Nature.

[29]  Juan I. Young,et al.  Ascorbate Induces Ten-Eleven Translocation (Tet) Methylcytosine Dioxygenase-mediated Generation of 5-Hydroxymethylcytosine*♦ , 2013, The Journal of Biological Chemistry.

[30]  A. Rao,et al.  DNA methylation and methylcytosine oxidation in cell fate decisions. , 2013, Current opinion in cell biology.

[31]  J. Jui,et al.  Dynamics of 5-hydroxymethylcytosine and chromatin marks in Mammalian neurogenesis. , 2013, Cell reports.

[32]  T. Down,et al.  Germline DNA Demethylation Dynamics and Imprint Erasure Through 5-Hydroxymethylcytosine , 2013, Science.

[33]  X. Shirley Liu,et al.  Tet3 CXXC Domain and Dioxygenase Activity Cooperatively Regulate Key Genes for Xenopus Eye and Neural Development , 2012, Cell.

[34]  B. Blencowe,et al.  5-hmC in the brain is abundant in synaptic genes and shows differences at the exon-intron boundary , 2012, Nature Structural &Molecular Biology.

[35]  J. Shacka.  Mouse models of neuronal ceroid lipofuscinoses: Useful pre-clinical tools to delineate disease pathophysiology and validate therapeutics , 2012, Brain Research Bulletin.

[36]  Xiaodong Cheng,et al.  Recognition and potential mechanisms for replication and erasure of cytosine hydroxymethylation , 2012, Nucleic acids research.

[37]  Chuan He,et al.  Thymine DNA glycosylase specifically recognizes 5-carboxylcytosine-modified DNA , 2012, Nature chemical biology.

[38]  Vijay K. Tiwari,et al.  DNA-binding factors shape the mouse methylome at distal regulatory regions , 2011, Nature.

[39]  Peng Jin,et al.  5-hmC–mediated epigenetic dynamics during postnatal neurodevelopment and aging , 2011, Nature Neuroscience.

[40]  A. Ballabio,et al.  Characterization of the CLEAR network reveals an integrated control of cellular clearance pathways. , 2011, Human molecular genetics.

[41]  Z. Deng,et al.  The role of Tet3 DNA dioxygenase in epigenetic reprogramming by oocytes , 2011, Nature.

[42]  Yang Wang,et al.  Tet-Mediated Formation of 5-Carboxylcytosine and Its Excision by TDG in Mammalian DNA , 2011, Science.

[43]  Chuan He,et al.  Tet Proteins Can Convert 5-Methylcytosine to 5-Formylcytosine and 5-Carboxylcytosine , 2011, Science.

[44]  A. Maiti,et al.  Thymine DNA Glycosylase Can Rapidly Excise 5-Formylcytosine and 5-Carboxylcytosine , 2011, The Journal of Biological Chemistry.

[45]  Andrea Ballabio,et al.  TFEB Links Autophagy to Lysosomal Biogenesis , 2011, Science.

[46]  J. Min,et al.  Genome-wide regulation of 5hmC, 5mC, and gene expression by Tet1 hydroxylase in mouse embryonic stem cells. , 2011, Molecular cell.

[47]  Juri Rappsilber,et al.  TET1 and hydroxymethylcytosine in transcription and DNA methylation fidelity , 2011, Nature.

[48]  W. Reik,et al.  Dynamic regulation of 5-hydroxymethylcytosine in mouse ES cells and during differentiation , 2011, Nature.

[49]  W. Reik,et al.  5-Hydroxymethylcytosine in the mammalian zygote is linked with epigenetic reprogramming. , 2011, Nature communications.

[50]  D. Patel,et al.  Structure of DNMT1-DNA Complex Reveals a Role for Autoinhibition in Maintenance DNA Methylation , 2011, Science.

[51]  G. Pfeifer,et al.  Reprogramming of the paternal genome upon fertilization involves genome-wide oxidation of 5-methylcytosine , 2011, Proceedings of the National Academy of Sciences.

[52]  L. Aravind,et al.  Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2 , 2010, Nature.

[53]  Yi Zhang,et al.  Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification , 2010, Nature.

[54]  M. Biel,et al.  Quantification of the sixth DNA base hydroxymethylcytosine in the brain. , 2010, Angewandte Chemie.

[55]  Cory Y. McLean,et al.  GREAT improves functional interpretation of cis-regulatory regions , 2010, Nature Biotechnology.

[56]  Jianhua Zhang,et al.  Lysosomal function in macromolecular homeostasis and bioenergetics in Parkinson's disease , 2010, Molecular Neurodegeneration.

[57]  H. Leonhardt,et al.  The multi-domain protein Np95 connects DNA methylation and histone modification , 2009, Nucleic acids research.

[58]  M. Nalls,et al.  Multicenter analysis of glucocerebrosidase mutations in Parkinson's disease. , 2009, The New England journal of medicine.

[59]  D. Reinberg,et al.  Role of the polycomb protein EED in the propagation of repressive histone marks , 2009, Nature.

[60]  N. Heintz,et al.  The Nuclear DNA Base 5-Hydroxymethylcytosine Is Present in Purkinje Neurons and the Brain , 2009, Science.

[61]  David R. Liu,et al.  Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1 , 2009, Science.

[62]  Juri Rappsilber,et al.  A model for transmission of the H3K27me3 epigenetic mark , 2008, Nature Cell Biology.

[63]  A. Iritani,et al.  Cis‐acting elements (E‐box and NBE) in the promoter region of three maternal genes (Histone H1oo, Nucleoplasmin 2, and Zygote Arrest 1) are required for oocyte‐specific gene expression in the mouse , 2008, Molecular reproduction and development.

[64]  Ke Zhang,et al.  Roles of the Clr4 methyltransferase complex in nucleation, spreading and maintenance of heterochromatin , 2008, Nature Structural &Molecular Biology.

[65]  R. Sobol.  CHIPping away at base excision repair. , 2008, Molecular cell.

[66]  G. Dianov,et al.  CHIP-mediated degradation and DNA damage-dependent stabilization regulate base excision repair proteins. , 2008, Molecular cell.

[67]  A. Lu,et al.  The human checkpoint sensor Rad9–Rad1–Hus1 interacts with and stimulates DNA repair enzyme TDG glycosylase , 2007, Nucleic acids research.

[68]  Yang Shi,et al.  Recognition of unmethylated histone H3 lysine 4 links BHC80 to LSD1-mediated gene repression , 2007, Nature.

[69]  L. Sowers,et al.  Endogenous cytosine damage products alter the site selectivity of human DNA maintenance methyltransferase DNMT1. , 2007, Cancer research.

[70]  A. Bird,et al.  Genomic DNA methylation: the mark and its mediators. , 2006, Trends in biochemical sciences.

[71]  J. Workman,et al.  Function and Selectivity of Bromodomains in Anchoring Chromatin-Modifying Complexes to Promoter Nucleosomes , 2002, Cell.

[72]  J. Jiricny,et al.  Modification of the human thymine‐DNA glycosylase by ubiquitin‐like proteins facilitates enzymatic turnover , 2002, The EMBO journal.

[73]  Ana Maria Cuervo,et al.  When lysosomes get old☆ , 2000, Experimental Gerontology.