Mite‐allergen exposure and spontaneous histamine release in monosensitive and polysensitive mite‐allergic patients

Forty‐three patients allergic to mites and suffering mainly from asthma were recruited: 25 were mite‐monosensitive and 18 were polysensitive, as determined by skin tests and specific serum IgE determinations with various allergens. In vitro spontaneous histamine release (SHR) by washed blood basophils was measured once or several times for each patient. Throughout this study, the mean periods of high and low mite‐allergen exposure were defined on the basis of relative indoor humidity and temperature data. For the mite‐monosensitive patients, there was a significant increase in mean SHR during the season of high mite‐allergen exposure as compared to the months of lower mite‐allergen presence (P < 0.002). No significant difference between mean SHR values was observed when comparing the monosensitive group during the season of high mite‐allergen exposure with polysensitive patients (allergic to mite and pollen) during the period of exposure to both allergens. Differences in mean SHR reported here emphasize the positive relationship between intense allergen exposure and the in vitro SHR increase in blood basophils of mite‐allergic patients.

[1]  K. Hsieh,et al.  Altered production of histamine-releasing factor (HRF) activity and responsiveness to HRF after immunotherapy in children with asthma. , 1990, The Journal of allergy and clinical immunology.

[2]  J. Warner,et al.  Measurement of airborne mite antigen in homes of asthmatic children , 1990, The Lancet.

[3]  J. Cavaillon,et al.  High in vitro spontaneous histamine release in long-term hemodialyzed patients. , 1990, The Journal of allergy and clinical immunology.

[4]  B. Hart,et al.  Ecology of house dust mites in Oxfordshire , 1990, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[5]  F. Tekaia,et al.  Seasonal increase of spontaneous histamine release in washed leucocytes from rhinitis patients sensitive to grass pollen , 1990, Clinical and experimental immunology.

[6]  U. Wahn,et al.  Spontaneous histamine release from washed leukocytes and whole blood in atopic and non‐atopic individuals , 1990, Allergy.

[7]  A. B. Lyons,et al.  Specific binding of human interleukin-3 and granulocyte-macrophage colony-stimulating factor to human basophils. , 1990, The Journal of allergy and clinical immunology.

[8]  H. Sampson,et al.  Spontaneous release of histamine from basophils and histamine-releasing factor in patients with atopic dermatitis and food hypersensitivity. , 1989, The New England journal of medicine.

[9]  R. Townley,et al.  Pharmacologic modulation of spontaneous histamine release. , 1989, Annals of allergy.

[10]  R. Townley,et al.  Spontaneous histamine release and histamine content in normal subjects and subjects with asthma. , 1989, The Journal of allergy and clinical immunology.

[11]  P. Kuna,et al.  The effect of preseasonal immunotherapy on the production of histamine-releasing factor (HRF) by mononuclear cells from patients with seasonal asthma: results of a double-blind, placebo-controlled, randomized study. , 1989, The Journal of allergy and clinical immunology.

[12]  K. Ohta,et al.  Modulation of human basophil histamine release by hemopoietic growth factors. , 1988, Journal of immunology.

[13]  L. Lichtenstein.  Histamine-releasing factors and IgE heterogeneity. , 1988, The Journal of allergy and clinical immunology.

[14]  M. Chapman,et al.  Seasonal variation in dust mite and grass-pollen allergens in dust from the houses of patients with asthma. , 1987, The Journal of allergy and clinical immunology.

[15]  G. Pauli,et al.  Clinical and immunologic evaluation of tyrosine-adsorbed Dermatophagoides pteronyssinus extract: a double-blind placebo-controlled trial. , 1984, The Journal of allergy and clinical immunology.

[16]  B. Lebel.  A high-sampling-rate automated continuous-flow fluorometric technique for the analysis of nanogram levels of histamine in biological samples. , 1983, Analytical biochemistry.

[17]  C. May,et al.  Observations on high spontaneous release of histamine from leucocytes in vitro , 1982, Clinical allergy.

[18]  L. Lichtenstein,et al.  Basophil "releasability" in patients with asthma. , 1980, The American review of respiratory disease.

[19]  J. A. Grant,et al.  Histamine-releasing activity (HRA). I. Production by mitogen- or antigen-stimulated human mononuclear cells. , 1979, Journal of immunology.

[20]  Wharton Gw,et al.  House dust mites. , 1976, Journal of medical entomology.

[21]  Van Bronswijk.  Dermatophagoides pteronyssinus (Trouessart, 1897) in mattress and floor dust in a temperate climate (Acari : Pyroglyphidae) , 1973 .