Assessment of a high-resolution candidate detector for prostate time-of-flight positron emission tomography.

We report on the measurements performed using a (22)Na source on a detector element for a magnetic resonance imaging-compatible time-of-flight-positron emission tomography endorectal prostate probe, with depth-of-interaction sensitivity. It is made from a LYSO scintillator crystal, wrapped with Lumirror, readout at both ends by means of silicon photomultipliers. With a detailed description of the data analysis procedure, we show that our results point to a 400 ps coincidence resolving time and, at the same time, to a depth-of-interaction resolution of 1 mm. These appealing features, along with the tiny 1.5 mm × 1.5 mm × 10 mm crystal size, are quite promising in view of the realization of a prototype probe.

[1]  Paolo Finocchiaro,et al.  Characterization of a scintillating mini-detector for time-of-flight positron emission tomography with depth-of-interaction. , 2012, The Review of scientific instruments.

[2]  F. Loddo,et al.  Time and DOI resolution measurements of minidetectors for a PET-TOF prostate probe , 2011, 2011 IEEE Nuclear Science Symposium Conference Record.

[3]  Jae Sung Lee,et al.  Positron emission tomography (PET) detectors with depth-of- interaction (DOI) capability , 2011 .

[4]  C. Levin,et al.  Investigating the temporal resolution limits of scintillation detection from pixellated elements: comparison between experiment and simulation , 2011, Physics in medicine and biology.

[5]  D. Townsend,et al.  Impact of Time-of-Flight on PET Tumor Detection , 2009, Journal of Nuclear Medicine.

[6]  Simon R Cherry,et al.  Experimental characterization and system simulations of depth of interaction PET detectors using 0.5 mm and 0.7 mm LSO arrays , 2009, Physics in medicine and biology.

[7]  L. Cosentino,et al.  Features of Silicon Photo Multipliers: Precision Measurements of Noise, Cross-Talk, Afterpulsing, Detection Efficiency , 2009, IEEE Transactions on Nuclear Science.

[8]  Peter Bruyndonckx,et al.  Monolithic scintillator PET detectors with intrinsic depth-of-interaction correction , 2009, Physics in medicine and biology.

[9]  Hao Peng,et al.  Novel Electro-Optical Coupling Technique for Magnetic Resonance-Compatible Positron Emission Tomography Detectors , 2009, Molecular imaging.

[10]  Jinyi Qi,et al.  Depth of interaction calibration for PET detectors with dual-ended readout by PSAPDs , 2009, Physics in medicine and biology.

[11]  A. Vandenbroucke,et al.  Performance characterization of a new high resolution PET scintillation detector , 2008, 2008 IEEE Nuclear Science Symposium Conference Record.

[12]  S. Siegel,et al.  A sub-millimeter resolution PET detector module using a multi-pixel photon counter array , 2008, 2008 IEEE Nuclear Science Symposium Conference Record.

[13]  L. Cosentino,et al.  Characterization of a Novel 100-Channel Silicon Photomultiplier—Part I: Noise , 2008, IEEE Transactions on Electron Devices.

[14]  L. Cosentino,et al.  Characterization of a Novel 100-Channel Silicon Photomultiplier—Part II: Charge and Time , 2008, IEEE Transactions on Electron Devices.

[15]  H. Murayama,et al.  Timing resolution improvement using DOI information in a four-layer scintillation detector for TOF-PET , 2008 .

[16]  Chien-Min Kao,et al.  Windowed image reconstruction for time-of-flight positron emission tomography , 2008, Physics in medicine and biology.

[17]  Suleman Surti,et al.  Benefit of Time-of-Flight in PET: Experimental and Clinical Results , 2008, Journal of Nuclear Medicine.

[18]  Y. Guyot,et al.  Understanding the scintillation efficiency of cerium-doped LSO, LYSO, YSO and LPS crystals from microwave study of photoconductivity and trapping , 2007 .

[19]  R. Zhu,et al.  Large size LSO and LYSO crystal scintillators for future high-energy physics and nuclear physics experiments , 2007 .

[20]  W. Moses Recent Advances and Future Advances in Time-of-Flight PET. , 2006, Nuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment.

[21]  L. Qin,et al.  Growth and characteristics of LYSO (Lu2(1−x−y)Y2xSiO5:Cey) scintillation crystals , 2005 .

[22]  H. Zaidi,et al.  Optimization of the effective light attenuation length of YAP:Ce and LYSO:Ce crystals for a novel geometrical PET concept , 2004, IEEE Symposium Conference Record Nuclear Science 2004..

[23]  Craig S. Levin,et al.  Design of a high-resolution and high-sensitivity scintillation crystal array for PET with nearly complete light collection , 2002 .

[24]  M. Suk,et al.  The HADES time-of-flight wall , 2002 .

[25]  N. Clinthorne,et al.  Multi-resolution image reconstruction for a high-resolution small animal PET device , 2003, 2003 IEEE Nuclear Science Symposium. Conference Record (IEEE Cat. No.03CH37515).