Regulatory T cells in obesity: the leptin connection.
暂无分享,去创建一个
[1] R. Klingenberg,et al. Intranasal Immunization With an Apolipoprotein B-100 Fusion Protein Induces Antigen-Specific Regulatory T Cells and Reduces Atherosclerosis , 2010, Arteriosclerosis, thrombosis, and vascular biology.
[2] M. Hurles,et al. Large, rare chromosomal deletions associated with severe early-onset obesity , 2010, Nature.
[3] E. Maury,et al. Adipokine dysregulation, adipose tissue inflammation and metabolic syndrome , 2010, Molecular and Cellular Endocrinology.
[4] Tsutomu Takeuchi,et al. Innate production of TH2 cytokines by adipose tissue-associated c-Kit+Sca-1+ lymphoid cells , 2009, Nature.
[5] S. O’Rahilly,et al. Human genetics illuminates the paths to metabolic disease , 2009, Nature.
[6] T. Chitnis,et al. Body size and risk of MS in two cohorts of US women , 2009, Neurology.
[7] M. Dietrich,et al. Feeding signals and brain circuitry , 2009, The European journal of neuroscience.
[8] A. Butler,et al. Obesity accelerates thymic aging. , 2009, Blood.
[9] J. Mauer,et al. MyD88 signaling in the CNS is required for development of fatty acid-induced leptin resistance and diet-induced obesity. , 2009, Cell metabolism.
[10] B. Wisse,et al. Does hypothalamic inflammation cause obesity? , 2009, Cell metabolism.
[11] M. Fessler,et al. Toll-like receptor signaling links dietary fatty acids to the metabolic syndrome , 2009, Current opinion in lipidology.
[12] R. Robertson,et al. β-Cell deterioration during diabetes: what's in the gun? , 2009, Trends in Endocrinology & Metabolism.
[13] A. Klip,et al. Direct and macrophage-mediated actions of fatty acids causing insulin resistance in muscle cells , 2009, Archives of physiology and biochemistry.
[14] Michael Famulok,et al. The nuclear receptor PPARγ selectively inhibits Th17 differentiation in a T cell–intrinsic fashion and suppresses CNS autoimmunity , 2009, The Journal of experimental medicine.
[15] H. Björkbacka,et al. Vaccines modulating lipoprotein autoimmunity as a possible future therapy for cardiovascular disease , 2009, Journal of internal medicine.
[16] V. Bourlier,et al. Role of macrophage tissue infiltration in obesity and insulin resistance. , 2009, Diabetes & metabolism.
[17] T. Kadowaki,et al. CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity , 2009, Nature Medicine.
[18] Carey N. Lumeng,et al. T-ing up inflammation in fat , 2009, Nature Medicine.
[19] Christophe Benoist,et al. Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters , 2009, Nature Medicine.
[20] B. Fox,et al. Cancer immunotherapy: the role regulatory T cells play and what can be done to overcome their inhibitory effects. , 2009, Current molecular medicine.
[21] J. Zieleński,et al. Normalization of Obesity-Associated Insulin Resistance through Immunotherapy: CD4+ T Cells Control Glucose Homeostasis , 2009, Nature Medicine.
[22] A. Garfield,et al. Role of central melanocortin pathways in energy homeostasis , 2009, Trends in Endocrinology & Metabolism.
[23] H. Björkbacka,et al. Atheroprotective Effects of Alum Are Associated With Capture of Oxidized LDL Antigens and Activation of Regulatory T Cells , 2009, Circulation research.
[24] Shailendra Giri,et al. Metformin Attenuated the Autoimmune Disease of the Central Nervous System in Animal Models of Multiple Sclerosis1 , 2009, The Journal of Immunology.
[25] K. Clément,et al. Deficiency and pharmacological stabilization of mast cells reduce diet-induced obesity and diabetes in mice , 2009, Nature Medicine.
[26] G. Hansson,et al. Vaccination against atherosclerosis? Induction of atheroprotective immunity , 2009, Seminars in Immunopathology.
[27] E. Shevach. Mechanisms of foxp3+ T regulatory cell-mediated suppression. , 2009, Immunity.
[28] J. Friedman. Obesity: Causes and control of excess body fat , 2009, Nature.
[29] A. Thomson,et al. Immunoregulatory functions of mTOR inhibition , 2009, Nature Reviews Immunology.
[30] B. Jenks,et al. Regulation of Proopiomelanocortin Gene Expression , 2009, Annals of the New York Academy of Sciences.
[31] H. Pownall,et al. The adipocyte IKK/NFkappaB pathway: a therapeutic target for insulin resistance. , 2009, Current opinion in investigational drugs.
[32] S. O’Rahilly,et al. Leptin: a pivotal regulator of human energy homeostasis. , 2009, The American journal of clinical nutrition.
[33] T. Horvath,et al. Fuel utilization by hypothalamic neurons: roles for ROS , 2009, Trends in Endocrinology & Metabolism.
[34] G. Berglund,et al. Immune responses against fibronectin modified by lipoprotein oxidation and their association with cardiovascular disease , 2009, Journal of internal medicine.
[35] M. Maghnie,et al. Thyroid function and structure are affected in childhood obesity. , 2008, The Journal of clinical endocrinology and metabolism.
[36] G. Hotamisligil,et al. Inflammation and endoplasmic reticulum stress in obesity and diabetes , 2008, International Journal of Obesity.
[37] Philip A Kern,et al. Adipocytokines and the metabolic complications of obesity. , 2008, The Journal of clinical endocrinology and metabolism.
[38] B. Levin,et al. Effects of leptin on rat ventromedial hypothalamic neurons. , 2008, Endocrinology.
[39] V. Dixit. Adipose‐immune interactions during obesity and caloric restriction: reciprocal mechanisms regulating immunity and health span , 2008, Journal of leukocyte biology.
[40] E. Bernal-Mizrachi,et al. β-cell failure as a complication of diabetes , 2008, Reviews in Endocrine and Metabolic Disorders.
[41] Tamas L. Horvath,et al. UCP2 mediates ghrelin’s action on NPY/AgRP neurons by lowering free radicals , 2008, Nature.
[42] H. Münzberg. Differential leptin access into the brain — A hierarchical organization of hypothalamic leptin target sites? , 2008, Physiology & Behavior.
[43] S. Markovic‐Plese,et al. Statins’ immunomodulatory potential against Th17 cell-mediated autoimmune response , 2008, Immunologic research.
[44] A. Tedgui,et al. Regulatory T‐cell immunity and its relevance to atherosclerosis , 2008, Journal of internal medicine.
[45] D. Eizirik,et al. The role for endoplasmic reticulum stress in diabetes mellitus. , 2008, Endocrine reviews.
[46] T. Horvath,et al. Neuronal control of energy homeostasis , 2008, FEBS letters.
[47] K. Clément,et al. Defective Leptin/Leptin Receptor Signaling Improves Regulatory T Cell Immune Response and Protects Mice From Atherosclerosis , 2007, Arteriosclerosis, thrombosis, and vascular biology.
[48] B. Strober,et al. Obesity in psoriasis: the metabolic, clinical and therapeutic implications. Report of an interdisciplinary conference and review , 2007, The British journal of dermatology.
[49] E. Shevach,et al. Foxp3+ regulatory T cells: selfishness under scrutiny. , 2007, Immunity.
[50] Allan Vaag,et al. Interleukin-1-receptor antagonist in type 2 diabetes mellitus. , 2007, The New England journal of medicine.
[51] U. Smith,et al. Adipose tissue distribution and risk of metabolic disease: does thiazolidinedione-induced adipose tissue redistribution provide a clue to the answer? , 2007, Diabetologia.
[52] V. De Rosa,et al. A key role of leptin in the control of regulatory T cell proliferation. , 2007, Immunity.
[53] Jun Ren,et al. Peroxisome proliferator-activated receptor (PPAR) in metabolic syndrome and type 2 diabetes mellitus. , 2007, Current diabetes reviews.
[54] G. Hotamisligil,et al. Inflammation and metabolic disorders , 2006, Nature.
[55] T. Horvath,et al. Thoughts for Food: Brain Mechanisms and Peripheral Energy Balance , 2006, Neuron.
[56] Jacqueline Capeau,et al. Recent advances in the relationship between obesity, inflammation, and insulin resistance. , 2006, European cytokine network.
[57] Thorsten Buch,et al. Agouti-related peptide–expressing neurons are mandatory for feeding , 2005, Nature Neuroscience.
[58] T. Horvath. The hardship of obesity: a soft-wired hypothalamus , 2005, Nature Neuroscience.
[59] H. Münzberg,et al. Molecular and anatomical determinants of central leptin resistance , 2005, Nature Neuroscience.
[60] V. De Rosa,et al. Leptin increase in multiple sclerosis associates with reduced number of CD4(+)CD25+ regulatory T cells. , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[61] S. Sakaguchi. Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self , 2005, Nature Immunology.
[62] R. Robertson. Chronic Oxidative Stress as a Central Mechanism for Glucose Toxicity in Pancreatic Islet Beta Cells in Diabetes* , 2004, Journal of Biological Chemistry.
[63] J. Flier,et al. Enhanced leptin sensitivity and attenuation of diet-induced obesity in mice with haploinsufficiency of Socs3 , 2004, Nature Medicine.
[64] A. Yoshimura,et al. Socs3 deficiency in the brain elevates leptin sensitivity and confers resistance to diet-induced obesity , 2004, Nature Medicine.
[65] G. Matarese,et al. The weight of leptin in immunity , 2004, Nature Reviews Immunology.
[66] A. La Cava,et al. The intricate interface between immune system and metabolism. , 2004, Trends in immunology.
[67] S. Sakaguchi. Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses. , 2004, Annual review of immunology.
[68] V. Sánchez-Margalet,et al. Leptin stimulates the oxidative burst in control monocytes but attenuates the oxidative burst in monocytes from HIV‐infected patients , 2003, Clinical and experimental immunology.
[69] J. Pfeilschifter,et al. Leptin and wound inflammation in diabetic ob/ob mice: differential regulation of neutrophil and macrophage influx and a potential role for the scab as a sink for inflammatory cells and mediators. , 2003, Diabetes.
[70] W. Banks,et al. Impaired transport of leptin across the blood-brain barrier in obesity is acquired and reversible. , 2003, American journal of physiology. Endocrinology and metabolism.
[71] V. Sánchez-Margalet,et al. Role of leptin as an immunomodulator of blood mononuclear cells: mechanisms of action , 2003, Clinical and experimental immunology.
[72] P. Garcia-Lorda,et al. Systemic inflammation, adipose tissue tumor necrosis factor, and leptin expression. , 2003, Obesity research.
[73] A. Rudensky,et al. Foxp3 programs the development and function of CD4+CD25+ regulatory T cells , 2003, Nature Immunology.
[74] R. Sun,et al. Expression of leptin receptors and response to leptin stimulation of human natural killer cell lines. , 2003, Biochemical and biophysical research communications.
[75] R. Sun,et al. Impaired natural killer (NK) cell activity in leptin receptor deficient mice: leptin as a critical regulator in NK cell development and activation. , 2002, Biochemical and biophysical research communications.
[76] Joseph L Evans,et al. Oxidative stress and stress-activated signaling pathways: a unifying hypothesis of type 2 diabetes. , 2002, Endocrine reviews.
[77] Graham M Lord,et al. Leptin inhibits the anti‐CD3‐driven proliferation of peripheral blood T cells but enhances the production of proinflammatory cytokines , 2002, Journal of leukocyte biology.
[78] J. Waring,et al. Protein tyrosine phosphatase 1B reduction regulates adiposity and expression of genes involved in lipogenesis. , 2002, Diabetes.
[79] Ethan M. Shevach,et al. CD4+CD25+ suppressor T cells: more questions than answers , 2002, Nature Reviews Immunology.
[80] Graham M Lord,et al. Balancing susceptibility to infection and autoimmunity: a role for leptin? , 2002, Trends in immunology.
[81] T. Mimori,et al. Leptin inhibits stress‐induced apoptosis of T lymphocytes , 2002, Clinical and experimental immunology.
[82] H. Ochs,et al. IPEX is a unique X-linked syndrome characterized by immune dysfunction, polyendocrinopathy, enteropathy, and a variety of autoimmune phenomena , 2001, Current opinion in pediatrics.
[83] Sayuri Yamazaki,et al. Immunologic tolerance maintained by CD25+ CD4+ regulatory T cells: their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance , 2001, Immunological reviews.
[84] Graham M Lord,et al. Requirement for Leptin in the Induction and Progression of Autoimmune Encephalomyelitis1 , 2001, The Journal of Immunology.
[85] T. Yamakawa,et al. T lymphopaenia in relation to body mass index and TNF‐α in human obesity: adequate weight reduction can be corrective , 2001, Clinical endocrinology.
[86] F. Caldefie‐Chézet,et al. Leptin: a potential regulator of polymorphonuclear neutrophil bactericidal action? , 2001, Journal of leukocyte biology.
[87] Young-Bum Kim,et al. Increased Energy Expenditure, Decreased Adiposity, and Tissue-Specific Insulin Sensitivity in Protein-Tyrosine Phosphatase 1B-Deficient Mice , 2000, Molecular and Cellular Biology.
[88] Alexander S. Banks,et al. Activation of Downstream Signals by the Long Form of the Leptin Receptor* , 2000, The Journal of Biological Chemistry.
[89] S. Woods,et al. Central nervous system control of food intake , 2000, Nature.
[90] V. Sánchez-Margalet,et al. Human leptin enhances activation and proliferation of human circulating T lymphocytes. , 2000, Cellular immunology.
[91] Graham M Lord,et al. Leptin protects mice from starvation-induced lymphoid atrophy and increases thymic cellularity in ob/ob mice. , 1999, The Journal of clinical investigation.
[92] V. Sánchez-Margalet,et al. Human leptin stimulates proliferation and activation of human circulating monocytes. , 1999, Cellular immunology.
[93] B. Kennedy,et al. Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene. , 1999, Science.
[94] J. Halaas,et al. Leptin and the regulation of body weight in mammals , 1998, Nature.
[95] K. Clément,et al. A frameshift mutation in human MC4R is associated with a dominant form of obesity , 1998, Nature Genetics.
[96] S. O’Rahilly,et al. A frameshift mutation in MC4R associated with dominantly inherited human obesity , 1998, Nature Genetics.
[97] Stephen R. Bloom,et al. Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression , 1998, Nature.
[98] A. Grüters,et al. Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans , 1998, Nature Genetics.
[99] K. Clément,et al. A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction , 1998, Nature.
[100] S. O’Rahilly,et al. Obesity and impaired prohormone processing associated with mutations in the human prohormone convertase 1 gene , 1997, Nature Genetics.
[101] S. O’Rahilly,et al. Congenital leptin deficiency is associated with severe early-onset obesity in humans , 1997, Nature.
[102] Rene Devos,et al. Identification and expression cloning of a leptin receptor, OB-R , 1995, Cell.
[103] M. Maffei,et al. Positional cloning of the mouse obese gene and its human homologue , 1994, Nature.
[104] B. Spiegelman,et al. Tumor Necrosis Factor α: A Key Component of the Obesity-Diabetes Link , 1994, Diabetes.
[105] B. Spiegelman,et al. Through thick and thin: Wasting, obesity, and TNFα , 1993, Cell.
[106] J. Clot,et al. Early effects of thyroidectomy and triiodothyronine administration on rat-liver mitochondria , 1979, Molecular and Cellular Endocrinology.
[107] Shimon Sakaguchi,et al. Regulatory T cells exert checks and balances on self tolerance and autoimmunity , 2010, Nature Immunology.
[108] S. Sebert,et al. Nutritional programming of the metabolic syndrome , 2009, Nature Reviews Endocrinology.
[109] A. Pinchera,et al. Melanocortin-4 receptor mutations in obesity. , 2009, Advances in clinical chemistry.
[110] David Metcalfe,et al. Obesity and diabetes: lipids, 'nowhere to run to'. , 2009, Clinical science.
[111] K. Cianflone,et al. Adipokines and the immune system: an adipocentric view. , 2008, Advances in experimental medicine and biology.
[112] Ruojing Yang,et al. c-Jun N-terminal kinase pathways in diabetes. , 2008, The international journal of biochemistry & cell biology.
[113] T. Horvath,et al. Developmental programming of the hypothalamus: a matter of fat , 2006, Nature Medicine.
[114] A. Freitas,et al. IPEX and FOXP3: clinical and research perspectives. , 2005, Journal of autoimmunity.
[115] Supporting Online Material , 2002 .
[116] W. A. Banks,et al. Leptin transport across the blood-brain barrier: implications for the cause and treatment of obesity. , 2001, Current pharmaceutical design.
[117] A. Zinn,et al. Profound obesity associated with a balanced translocation that disrupts the SIM1 gene. , 2000, Human molecular genetics.