Studies of Tissue Response to Injections of Enzymes: III. Preliminary Report. Development of Subcutaneous "Nodules" and Tissue Hexosamine Changes in Rabbits Following a Single Subcutaneous Injection of Streptokinase

Since 1893, activation of the serum proteolytic enzymes has been accomplished by a variety of methods and agents. Activation of the serum proteolytic enzyme by means of streptokinase, the beta hemolytic streptococcal kinase, has been recently demonstrated. The significant plasma and tissue hexosamine changes, as well as the subcutaneous "nodules" which developed at the injection sites, resemble those observed in the trypsin treated group. Although trypsin and the serum proteolytic enzyme are not identical, they have many characteristics in common.

[1]  A. Degraff,et al.  Studies of Tissue Response to Injections of Enzymes: I. The Development of Subcutaneous "Nodules" Following a Single Subcutaneous Injection of Trypsin , 1950 .

[2]  A. Degraff,et al.  Studies of Tissue Response to Injections of Enzymes: II. Changes in Rabbit Plasma and Tissue Hexosamine Induced by a Single Subcutaneous Injection of Trypsin , 1950 .

[3]  M. Schubert,et al.  Studies of Tissue Response to Injections of Enzymes: IV. Tissue, Hexosamine, and Hematologic Changes in Rabbits Following a Single Subcutaneous Injection of Hyaluronidase , 1950 .

[4]  L. R. Christensen.  THE ACTIVATION OF PLASMINOGEN BY CHLOROFORM , 1946, The Journal of general physiology.

[5]  M. H. Kaplan,et al.  Studies of streptococcal fibrinolysis; the dissimilarity of serum protease and trypsin as indicated by the separate specificities of their kinases, fibrinolysin and enterokinase. , 1946, The Journal of clinical investigation.

[6]  M. H. Kaplan,et al.  STUDIES OF STREPTOCOCCAL FIBRINOLYSIS. II. THE INHIBITION OF STREPTOCOCCAL FIBRINOLYSIS BY ANTIFIBRINOLYSIN AND ANTIPROTEASE. , 1946, The Journal of clinical investigation.

[7]  S. O. Andrade,et al.  ANTAGONISM BETWEEN HEPARIN AND PLASMA TRYPSIN. , 1945, Science.

[8]  C. Macleod,et al.  A PROTEOLYTIC ENZYME OF SERUM: CHARACTERIZATION, ACTIVATION, AND REACTION WITH INHIBITORS , 1945, The Journal of general physiology.

[9]  L. R. Christensen.  STREPTOCOCCAL FIBRINOLYSIS: A PROTEOLYTIC REACTION DUE TO A SERUM ENZYME ACTIVATED BY STREPTOCOCCAL FIBRINOLYSIN , 1945, The Journal of general physiology.

[10]  M. H. Kaplan,et al.  Nature and Role of the Lytic Factor in Hemolytic Streptococcal Fibrinolysis.∗ , 1944 .

[11]  J. Ferguson.  A NEW BLOOD-CLOTTING THEORY. , 1943, Science.

[12]  C. S. Davidson,et al.  STUDIES ON BLOOD COAGULATION: A PROTEOLYTIC ENZYME PREPARED FROM CALCIUM AND PLATELET FREE NORMAL HUMAN BLOOD PLASMA. , 1942, The Journal of clinical investigation.

[13]  C. Pope.  Disaggregation of Proteins by Enzymes. , 1938 .

[14]  Hugh Pope.  A PHANTOM CITY1 , 1938 .

[15]  Sho Yamakawa.  THE AUTODIGESTION OF NORMAL SERUM THROUGH THE ACTION OF CERTAIN CHEMICAL AGENTS. I , 1918, The Journal of experimental medicine.

[16]  E. Opie,et al.  ENZYMES OF TUBERCULOUS TISSUE , 1908, The Journal of experimental medicine.

[17]  M. Kaplan.  STUDIES OF STREPTOCOCCAL FIBRINOLYSIS. I. THE DISSIMILARITY OF SERUM PROTEASE AND TRYPSIN AS INDICATED BY THE SEPARATE SPECIFICITIES OF THEIR KINASES, FIBRINOLYSIN AND ENTEROKINASE. , 1946, The Journal of clinical investigation.