Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers

[1]  G. Turashvili,et al.  A method for quantifying normal human mammary epithelial stem cells with in vivo regenerative ability , 2008, Nature Medicine.

[2]  J. Jonkers,et al.  Mouse models for BRCA1 associated tumorigenesis: From fundamental insights to preclinical utility , 2008, Cell cycle.

[3]  Matthew E Ritchie,et al.  Integrative analysis of RUNX1 downstream pathways and target genes , 2008, BMC Genomics.

[4]  Marco Marra,et al.  Transcriptome analysis of the normal human mammary cell commitment and differentiation process. , 2008, Cell stem cell.

[5]  T. Rebbeck,et al.  Risk-reducing salpingo-oophorectomy for the prevention of BRCA1- and BRCA2-associated breast and gynecologic cancer: a multicenter, prospective study. , 2008, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[6]  S. Merajver,et al.  BRCA1 regulates human mammary stem/progenitor cell fate , 2008, Proceedings of the National Academy of Sciences.

[7]  D. Birnbaum,et al.  ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome. , 2007, Cell stem cell.

[8]  Zhiyuan Hu,et al.  Identification of conserved gene expression features between murine mammary carcinoma models and human breast tumors , 2007, Genome Biology.

[9]  M. Bissell,et al.  Evidence for a stem cell hierarchy in the adult human breast , 2007, The Journal of cell biology.

[10]  Marie-Liesse Asselin-Labat,et al.  Gata-3 is an essential regulator of mammary-gland morphogenesis and luminal-cell differentiation , 2007, Nature Cell Biology.

[11]  Y. Li,et al.  Prevention of Brca1-Mediated Mammary Tumorigenesis in Mice by a Progesterone Antagonist , 2006, Science.

[12]  S. Narod Modifiers of risk of hereditary breast cancer , 2006, Oncogene.

[13]  François Vaillant,et al.  Steroid hormone receptor status of mouse mammary stem cells. , 2006, Journal of the National Cancer Institute.

[14]  Haiyan I. Li,et al.  Purification and unique properties of mammary epithelial stem cells , 2006, Nature.

[15]  John L Hopper,et al.  Analysis of cancer risk and BRCA1 and BRCA2 mutation prevalence in the kConFab familial breast cancer resource , 2006, Breast Cancer Research.

[16]  François Vaillant,et al.  Generation of a functional mammary gland from a single stem cell , 2006, Nature.

[17]  S. Furuta,et al.  Depletion of BRCA1 impairs differentiation but enhances proliferation of mammary epithelial cells. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[18]  D. Ross,et al.  Basal cytokeratins and their relationship to the cellular origin and functional classification of breast cancer , 2005, Breast Cancer Research.

[19]  A. Howell,et al.  A putative human breast stem cell population is enriched for steroid receptor-positive cells. , 2005, Developmental biology.

[20]  M. Kotb,et al.  Human Lymphoid and Myeloid Cell Development in NOD/LtSz-scid IL2Rγnull Mice Engrafted with Mobilized Human Hemopoietic Stem Cells 12 , 2004, The Journal of Immunology.

[21]  A. Ashworth,et al.  Hallmarks of 'BRCAness' in sporadic cancers , 2004, Nature Reviews Cancer.

[22]  Jean YH Yang,et al.  Bioconductor: open software development for computational biology and bioinformatics , 2004, Genome Biology.

[23]  W. Foulkes,et al.  BRCA1 and BRCA2: 1994 and beyond , 2004, Nature Reviews Cancer.

[24]  A. Gown,et al.  Immunohistochemical and Clinical Characterization of the Basal-Like Subtype of Invasive Breast Carcinoma , 2004, Clinical Cancer Research.

[25]  R. Weinberg,et al.  Reconstruction of functionally normal and malignant human breast tissues in mice. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[26]  W. Foulkes BRCA1 functions as a breast stem cell regulator , 2004, Journal of Medical Genetics.

[27]  G. Dontu,et al.  In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells. , 2003, Genes & development.

[28]  E. Kubista,et al.  Brca1 regulates in vitro differentiation of mammary epithelial cells , 2002, Oncogene.

[29]  Susan L Neuhausen,et al.  Prophylactic oophorectomy in carriers of BRCA1 or BRCA2 mutations. , 2002, The New England journal of medicine.

[30]  J. Satagopan,et al.  Risk-reducing salpingo-oophorectomy in women with a BRCA1 or BRCA2 mutation. , 2002, The New England journal of medicine.

[31]  Mina J Bissell,et al.  Isolation, immortalization, and characterization of a human breast epithelial cell line with stem cell properties. , 2002, Genes & development.

[32]  Ashok R Venkitaraman,et al.  Cancer Susceptibility and the Functions of BRCA1 and BRCA2 , 2002, Cell.

[33]  C. Eaves,et al.  Characterization of bipotent mammary epithelial progenitor cells in normal adult human breast tissue , 2001, Breast Cancer Research and Treatment.

[34]  Christian A. Rees,et al.  Molecular portraits of human breast tumours , 2000, Nature.

[35]  Thomas Ried,et al.  Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation , 1999, Nature Genetics.

[36]  L. Hennighausen,et al.  Cre-mediated gene deletion in the mammary gland. , 1997, Nucleic acids research.

[37]  R. Nagle,et al.  Characterization of breast carcinomas by two monoclonal antibodies distinguishing myoepithelial from luminal epithelial cells. , 1986, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[38]  P. S. Wolters,et al.  Towards an improved serum-free, chemically defined medium for long-term culturing of cerebral cortex tissue , 1984, Neuroscience & Biobehavioral Reviews.

[39]  H. Bern,et al.  Development of mammary tumors from hyperplastic alveolar nodules transplanted into gland-free mammary fat pads of female C3H mice. , 1959, Cancer research.

[40]  Gordon K Smyth,et al.  Statistical Applications in Genetics and Molecular Biology Linear Models and Empirical Bayes Methods for Assessing Differential Expression in Microarray Experiments , 2011 .

[41]  E. Rosen,et al.  The breast cancer susceptibility gene BRCA1 regulates progesterone receptor signaling in mammary epithelial cells. , 2006, Molecular endocrinology.

[42]  A. Richardson,et al.  Abnormalities of the inactive X chromosome are a common feature of BRCA1 mutant and sporadic basal-like breast cancer. , 2005, Cold Spring Harbor symposia on quantitative biology.

[43]  G. Sauter,et al.  KIT (CD117)-positive breast cancers are infrequent and lack KIT gene mutations. , 2004, Clinical cancer research : an official journal of the American Association for Cancer Research.

[44]  A. Howell,et al.  The proliferation of normal human breast tissue implanted into athymic nude mice is stimulated by estrogen but not progesterone. , 1995, Endocrinology.