Severe reduction of free-form ADAMTS13, unbound to von Willebrand factor, in plasma of patients with HELLP syndrome.

Severely decreased ADAMTS13 unbound to VWF may play a key role in the pathogenesis of HELLP syndrome.A qualitative ADAMTS13 assay may be important for diagnosing HELLP syndrome.

[1]  Y. Yoshida.  Severe reduction of free-form ADAMTS13, unbound to von Willebrand factor, in plasma of patients with HELLP syndrome , 2018 .

[2]  Xi Chen,et al.  Expression of ADAMTS13 in Normal and Abnormal Placentae and Its Potential Role in Angiogenesis and Placenta Development , 2017, Arteriosclerosis, thrombosis, and vascular biology.

[3]  M. Matsumoto,et al.  Poor responder to plasma exchange therapy in acquired thrombotic thrombocytopenic purpura is associated with ADAMTS13 inhibitor boosting: visualization of an ADAMTS13 inhibitor complex and its proteolytic clearance from plasma , 2015, Transfusion.

[4]  M. Matsumoto,et al.  ADAMTS13 unbound to larger von Willebrand factor multimers in cryosupernatant: implications for selection of plasma preparations for thrombotic thrombocytopenic purpura treatment , 2013, Transfusion.

[5]  O. Pourrat,et al.  ADAMTS13 deficiency in severe postpartum HELLP syndrome , 2013, British journal of haematology.

[6]  Kevin W Eliceiri,et al.  NIH Image to ImageJ: 25 years of image analysis , 2012, Nature Methods.

[7]  R. Levine,et al.  Pathogenesis of preeclampsia. , 2010, Annual review of pathology.

[8]  J. Sadler,et al.  Multi‐step binding of ADAMTS‐13 to von Willebrand factor , 2009, Journal of thrombosis and haemostasis : JTH.

[9]  A. Franx,et al.  Acute activation of the endothelium results in increased levels of active von Willebrand factor in hemolysis, elevated liver enzymes and low platelets (HELLP) syndrome , 2006, Journal of thrombosis and haemostasis : JTH.

[10]  T. Matsuyama,et al.  Novel monoclonal antibody‐based enzyme immunoassay for determining plasma levels of ADAMTS13 activity , 2006, Transfusion.

[11]  M. Lazzari,et al.  Factor VIII and von Willebrand factor changes during normal pregnancy and puerperium , 2003, Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis.

[12]  B. Brenner,et al.  Procoagulant and Anticoagulant Mechanisms in Human Placenta , 2003, Seminars in thrombosis and hemostasis.

[13]  P. Mannucci,et al.  Mild to moderate reduction of a von Willebrand factor cleaving protease (ADAMTS-13) in pregnant women with HELLP microangiopathic syndrome. , 2003, Haematologica.

[14]  B. Lämmle,et al.  Ten years of prophylactic treatment with fresh‐frozen plasma in a child with chronic relapsing thrombotic thrombocytopenic purpura as a result of a congenital deficiency of von Willebrand factor‐cleaving protease , 2001, British journal of haematology.

[15]  C. Damsky,et al.  Preeclampsia is associated with failure of human cytotrophoblasts to mimic a vascular adhesion phenotype. One cause of defective endovascular invasion in this syndrome? , 1997, The Journal of clinical investigation.

[16]  E. Dejana,et al.  Human cytotrophoblasts adopt a vascular phenotype as they differentiate. A strategy for successful endovascular invasion? , 1997, The Journal of clinical investigation.

[17]  A. Voller,et al.  Factor-VIII-related antigen: measurement by enzyme immunoassay. , 1976, British medical journal.