Anaesthesia for the surgeon‐anaesthetist in difficult situations

In many developing countries the physicianJpopulation ratio is less than 1 :20,000. Under these conditions the ideal of employing a physician for routine anaesthesia is hardly justified and often impossible. Unfortunately, the conditioning of surgeons trained in the more affluent areas is such that most are unwilling or unable to administer their own spinal or local anaesthetics. Many anaesthetists, particularly those trained within the British Commonwealth, lack experience of anaesthesia without the aid of compressed gases and thus are unable to train technicians for work outside major centres. There is great need for a safe, simple anaesthetic that can be administered by the surgeon or an assistant under his supervision. It must leave the surgeon free to forget about the patient’s general condition and airway whilst he concentrates on the surgery. Recovery should be rapid and free from any special nursing requirements. In Nigeria phencyclidine was found to meet some of these criterial. Unfortunately this drug also caused major psychotomimetic disturbances which led to its withdrawal from the field of human anaesthesia. The possibility that the phencyclidine congener 2(0-chlorophenyl)-2 methylamino cyclohexanone hydrochloride (Ketamine*) might be an improvement on the parent compound was suggested from published reports2-8 which concern both the clinical and pharmacological aspects of the drug. The drug is a water soluble compound which may be administered by intravenous or intramuscular injection. Intravenous administration proved disappointing in our hands. It was found to be unreliable in producing anaesthesia, to give such a short period of analgesia that constant attendance was necessary, to cause a marked rise in blood pressure and distressing hallucinations. Although the

[1]  J. Pender Dissociative anesthesia. , 1970, California medicine.

[2]  K. Kaya,et al.  Studies of the mechanism of cardiovascular responses to CI-581. , 1968, Anesthesiology.

[3]  K. T. Proshunin [Classification of tetanus]. , 1968, Sovetskaia meditsina.

[4]  G. Corssen,et al.  A New Parenteral Anesthetic-CI-581: Its Effect on Intraocular Pressure , 1967 .

[5]  G. Corssen,et al.  Cl-581: a new non-barbiturate short-acting anesthetic for surgery in burns. , 1967, Michigan medicine.

[6]  F. W. Roberts A new intramuscular anaesthetic for small children. A report of clinical trials of CI-581. , 1967, Anaesthesia.

[7]  G. Corssen Sixth National Burn Seminar. Recent developments in the anesthetic management of burned patients. , 1967, Journal of Trauma.

[8]  M. Lowenthal,et al.  Chlordiazepoxide in the treatment of tetanus. , 1966, The Journal of tropical medicine and hygiene.

[9]  G. Corssen,et al.  CI-581: an intravenous or intramuscular anesthetic. for office ophthalmic surgery. , 1966, American journal of ophthalmology-glaucoma.

[10]  E F Domino,et al.  Dissociative Anesthesia: Further Pharmacologic Studies and First Clinical Experience with the Phencyclidine Derivative Cl‐581 , 1966, Anesthesia and analgesia.

[11]  E. Domino,et al.  Pharmacologic effects of CI‐581, a new dissociative anesthetic, in man , 1965, Clinical pharmacology and therapeutics.

[12]  C. Ensor,et al.  GENERAL ANESTHETIC AND OTHER PHARMACOLOGICAL PROPERTIES OF 2-(O-CHLOROPHENYL)-2-METHYLAMINO CYCLOHEXANONE HCL (CI-58L). , 1965, The Journal of new drugs.

[13]  R. Y. Gool,et al.  ANAESTHESIA FOR UNDER-DOCTORED AREAS. A TRIAL OF PHENCYCLIDINE IN NIGERIA. , 1964, Anaesthesia.

[14]  L. Phillips,et al.  Operative stress and the adrenals , 1959, Anaesthesia.

[15]  G. Stirling,et al.  Size of the Adrenals in Jamaicans , 1958, British medical journal.