Effects of traumatic life events, cognitive biases and variation in dopaminergic genes on psychosis proneness

Recent studies have provided evidence that interactions between variation in dopaminergic genes and stressful experiences might impact risk of psychosis. However, it remains unknown whether these interactions impact the development of subclinical symptoms, including psychotic‐like experiences (PLEs). In this study, we aimed to test the effects of interactions between variation in dopaminergic genes and traumatic life events (TLEs) on a severity of PLEs.

[1]  S. Moritz,et al.  Mediating role of aberrant salience and self-disturbances for the relationship between childhood trauma and psychotic-like experiences in the general population , 2019, Schizophrenia Research.

[2]  D. Cicero,et al.  A combination of self-disturbances and psychotic-like experiences. A cluster analysis study on a non-clinical sample in Poland , 2019, Psychiatry Research.

[3]  R. Murray,et al.  Interaction between childhood adversity and functional polymorphisms in the dopamine pathway on first-episode psychosis , 2019, Schizophrenia Research.

[4]  M. Joëls,et al.  Effects of early life stress on biochemical indicators of the dopaminergic system: A 3 level meta-analysis of rodent studies , 2018, Neuroscience & Biobehavioral Reviews.

[5]  Steven Taylor,et al.  Association between COMT Val158Met and psychiatric disorders: A comprehensive meta‐analysis , 2018, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.

[6]  B. Nelson,et al.  Self-disturbances, cognitive biases and insecure attachment as mechanisms of the relationship between traumatic life events and psychotic-like experiences in non-clinical adults – A path analysis , 2018, Psychiatry Research.

[7]  I. Myin-Germeys,et al.  The role of stress‐regulation genes in moderating the association of stress and daily‐life psychotic experiences , 2017, Acta psychiatrica Scandinavica.

[8]  A. Moustafa,et al.  Interactions Between Variation in Candidate Genes and Environmental Factors in the Etiology of Schizophrenia and Bipolar Disorder: a Systematic Review , 2017, Molecular Neurobiology.

[9]  B. Nelson,et al.  The role of self-disturbances and cognitive biases in the relationship between traumatic life events and psychosis proneness in a non-clinical sample , 2017, Schizophrenia Research.

[10]  J. O. Johannessen,et al.  The Effect of Substance Use on 10-Year Outcome in First-Episode Psychosis , 2017, Schizophrenia bulletin.

[11]  T. Woodward,et al.  Dopamine, cognitive biases and assessment of certainty: A neurocognitive model of delusions. , 2017, Clinical psychology review.

[12]  A. Moustafa,et al.  Toward a unified theory of childhood trauma and psychosis: A comprehensive review of epidemiological, clinical, neuropsychological and biological findings , 2017, Neuroscience & Biobehavioral Reviews.

[13]  J. Kłosowska,et al.  Attentional focus moderates the relationship between attention to threat bias and delusion-like experiences in healthy adults , 2017, European Psychiatry.

[14]  Robin M. Murray,et al.  The Role of Genes, Stress, and Dopamine in the Development of Schizophrenia , 2017, Biological Psychiatry.

[15]  Xiancang Ma,et al.  Associations between dopamine D2 receptor gene polymorphisms and schizophrenia risk: a PRISMA compliant meta-analysis , 2016, Neuropsychiatric disease and treatment.

[16]  L. Alloy,et al.  Trauma and the psychosis spectrum: A review of symptom specificity and explanatory mechanisms. , 2016, Clinical psychology review.

[17]  C. Pantelis,et al.  A review of vulnerability and risks for schizophrenia: Beyond the two hit hypothesis , 2016, Neuroscience & Biobehavioral Reviews.

[18]  J. Rybakowski,et al.  Editorial: Endophenotypes for Schizophrenia and Mood Disorders: Implications from Genetic, Biochemical, Cognitive, Behavioral, and Neuroimaging Studies , 2016, Front. Psychiatry.

[19]  A. Fresán,et al.  The Role of a Catechol-O-Methyltransferase (COMT) Val158Met Genetic Polymorphism in Schizophrenia: A Systematic Review and Updated Meta-analysis on 32,816 Subjects , 2016, NeuroMolecular Medicine.

[20]  M. Nour,et al.  Dopamine and the aberrant salience hypothesis of schizophrenia , 2016, World psychiatry : official journal of the World Psychiatric Association.

[21]  R. Dudley,et al.  Psychosis, Delusions and the “Jumping to Conclusions” Reasoning Bias: A Systematic Review and Meta-analysis , 2015, Schizophrenia bulletin.

[22]  F. Smit,et al.  Trauma and recent life events in individuals at ultra high risk for psychosis: Review and meta-analysis , 2015, Schizophrenia Research.

[23]  M. Cella,et al.  Cognitive biases mediate the relationship between temperament and character and psychotic-like experiences in healthy adults , 2015, Psychiatry Research.

[24]  C. Spencer,et al.  Biological Insights From 108 Schizophrenia-Associated Genetic Loci , 2014, Nature.

[25]  P. Grant,et al.  Psychosis-proneness correlates with expression levels of dopaminergic genes , 2014, European Psychiatry.

[26]  R. Murray,et al.  Schizophrenia: an integrated sociodevelopmental-cognitive model , 2014, The Lancet.

[27]  D. Naber,et al.  Dopaminergic modulation of probabilistic reasoning and overconfidence in errors: a double-blind study. , 2014, Schizophrenia bulletin.

[28]  Melissa J. Green,et al.  Catechol-O-methyltransferase (COMT) genotype moderates the effects of childhood trauma on cognition and symptoms in schizophrenia. , 2014, Journal of psychiatric research.

[29]  P. Fusar-Poli,et al.  Prevalence of self-reported childhood abuse in psychosis: A meta-analysis of retrospective studies , 2013, Psychiatry Research.

[30]  M. Dewey,et al.  Life Events and Psychosis: A Review and Meta-analysis , 2013, Schizophrenia bulletin.

[31]  Wolfgang Tschacher,et al.  Development of the Davos Assessment of Cognitive Biases Scale (DACOBS) , 2013, Schizophrenia Research.

[32]  C. Corcoran,et al.  Attributional style among youth at clinical risk for psychosis , 2013, Early intervention in psychiatry.

[33]  R. Emsley,et al.  Current Paranoid Thinking in Patients With Delusions: The Presence of Cognitive-Affective Biases , 2012, Schizophrenia bulletin.

[34]  Mark Slifstein,et al.  The nature of dopamine dysfunction in schizophrenia and what this means for treatment. , 2012, Archives of general psychiatry.

[35]  W. Veling,et al.  The validity of the 16-item version of the Prodromal Questionnaire (PQ-16) to screen for ultra high risk of developing psychosis in the general help-seeking population. , 2012, Schizophrenia bulletin.

[36]  J. Read,et al.  Childhood Adversities Increase the Risk of Psychosis: A Meta-analysis of Patient-Control, Prospective- and Cross-sectional Cohort Studies , 2012, Schizophrenia bulletin.

[37]  T. Lataster,et al.  Evidence that interactive effects of COMT and MTHFR moderate psychotic response to environmental stress , 2012, Acta psychiatrica Scandinavica.

[38]  T. Lataster,et al.  COMT Val158Met–Stress Interaction in Psychosis: Role of Background Psychosis Risk , 2011, CNS neuroscience & therapeutics.

[39]  R. Murray,et al.  Dopamine synthesis capacity before onset of psychosis: a prospective [18F]-DOPA PET imaging study. , 2011, The American journal of psychiatry.

[40]  Peter B. Jones,et al.  Reliability and comparability of psychosis patients' retrospective reports of childhood abuse. , 2011, Schizophrenia bulletin.

[41]  M. Frank,et al.  Dopaminergic Genes Predict Individual Differences in Susceptibility to Confirmation Bias , 2011, The Journal of Neuroscience.

[42]  Kim Mouridsen,et al.  Dopaminergic stimulation enhances confidence and accuracy in seeing rapidly presented words. , 2011, Journal of vision.

[43]  P. McGuire,et al.  Impaired verbal self-monitoring in individuals at high risk of psychosis , 2009, Psychological Medicine.

[44]  Kjell Någren,et al.  C957T polymorphism of the human dopamine D2 receptor gene predicts extrastriatal dopamine receptor availability in vivo , 2009, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

[45]  M. Ikeda,et al.  Meta-analysis of association between genetic variants in COMT and schizophrenia: An update , 2009, Schizophrenia Research.

[46]  C. Fernyhough,et al.  Social predictors of psychotic experiences: specificity and psychological mechanisms. , 2008, Schizophrenia bulletin.

[47]  S. Kapur,et al.  ‘Jumping to conclusions’ and delusions in psychosis: Relationship and response to treatment , 2008, Schizophrenia Research.

[48]  L. Fañanás,et al.  Evidence that the COMTVal158Met polymorphism moderates sensitivity to stress in psychosis: An experience‐sampling study , 2008, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.

[49]  M. Egan,et al.  Functional analysis of genetic variation in catechol-O-methyltransferase (COMT): effects on mRNA, protein, and enzyme activity in postmortem human brain. , 2004, American journal of human genetics.

[50]  K. Någren,et al.  C957T polymorphism of the dopamine D2 receptor (DRD2) gene affects striatal DRD2 availability in vivo , 2004, Molecular Psychiatry.

[51]  Jens C. Pruessner,et al.  Dopamine Release in Response to a Psychological Stress in Humans and Its Relationship to Early Life Maternal Care: A Positron Emission Tomography Study Using [11C]Raclopride , 2004, The Journal of Neuroscience.

[52]  N. Saitou,et al.  Synonymous mutations in the human dopamine receptor D2 (DRD2) affect mRNA stability and synthesis of the receptor. , 2003, Human molecular genetics.

[53]  O. Hart,et al.  The psychometric characteristics of the traumatic experiences checklist (TEC): first findings among psychiatric outpatients , 2002 .

[54]  I. Gottesman,et al.  Twin studies of schizophrenia: from bow-and-arrow concordances to star wars Mx and functional genomics. , 2000, American journal of medical genetics.

[55]  M Warner,et al.  Jumping to conclusions. , 1987, Analytical chemistry.

[56]  Hemmingsen,et al.  SCHIZOPHRENIA-AN INTEGRATED , 2013 .

[57]  J. Ballenger Reliability and Comparability of Psychosis Patients' Retrospective Reports of Childhood Abuse , 2012 .

[58]  E. Stip,et al.  Toxic Psychoses as Pharmacological Models of Schizophrenia , 2005 .

[59]  S. Kapur Psychosis as a state of aberrant salience: a framework linking biology, phenomenology, and pharmacology in schizophrenia. , 2003, The American journal of psychiatry.

[60]  J. Lieberman,et al.  Neural development, cell-cell signaling, and the "two-hit" hypothesis of schizophrenia. , 2001, Schizophrenia bulletin.