위암에서 Thymidylate Synthase의 발현에 대한 연구

Thymidylate synthase catalyzes the reductive methylation of 2′-deoxyuridine 5-monophosphate (dUMP) by transfer of a methylene group from a cofactor, CH H folate, to generate deoxythymidine-5′-monophoshate (dTMP). dTMP is further phosphorylated to the 2 4 triphosphate state (dTTP), which is a direct precursor for DNA synthesis. Since the TS catalyzed reaction is the sole intracellular de novo source of dTMP, the inhibition of TS results in the cessation of cellular proliferation and growth.