Prognostic significance of karyotype analysis in children with acute lymphoblastic leukemia

Chromosome studies, using bone marrow samples of 26 pretreated children (below 15 years of age) with Acute Lymphoblastic Leukemia were carried out to explore the potentialities of applying chromosomal findings as a prognostic indicator in these patients. Abnormal karyotype was identified in 15 patients (57·6 per cent). The chromosomes frequently involved in non‐random numerical abnormalities were Nos. 8, 18 and 21. Structural chromosome changes observed consisted of deletion 6q‐ and translocation t (4; 11).

[1]  Chessells Jm.  Acute leukaemia in children , 1986 .

[2]  Y. Kaneko,et al.  Correlation of karyotype with clinical features in acute lymphoblastic leukemia. , 1982, Cancer research.

[3]  J. Rowley,et al.  Associations between morphology, karyotype, and clinical features in myeloid leukemias. , 1987, Human pathology.

[4]  F. Mitelman,et al.  Numerical chromosome aberrations in human neoplasia. , 1986, Cancer genetics and cytogenetics.

[5]  A. Goddard,et al.  Chromosome aberrations and cancer. , 1991, Science.

[6]  G. Rechavi,et al.  Biologic and cytogenetic characteristics of leukemia in infants , 1989, Cancer.

[7]  M. Oken,et al.  Recurrent chromosomal defects are found in most patients with non-Hodgkin's-lymphoma. , 1984, Cancer genetics and cytogenetics.

[8]  C. Bloomfield,et al.  Chromosomal abnormalities and their clinical significance in acute lymphoblastic leukemia. Third International Workshop on Chromosomes in Leukemia. , 1983, Cancer research.

[9]  G. A. Johnson,et al.  Chromosome studies in 17 patients with the Sézary syndrome , 1985, Cancer.

[10]  M. Kocova,et al.  Translocation 4;11 acute leukemia: three case reports and review of the literature. , 1985, Cancer genetics and cytogenetics.

[11]  A. Bleyer,et al.  Analysis of prognostic factors in acute lymphoblastic leukemia. , 1986, Medical and pediatric oncology.

[12]  G. Kitchingman,et al.  Clinical and laboratory characteristics of acute leukemia with the 4;11 translocation , 1986 .

[13]  G. Reaman,et al.  Acute lymphoblastic leukemia in childhood. , 1985, Pediatric clinics of North America.

[14]  S. Sallan,et al.  The childhood leukemias. , 1981, The Journal of pediatrics.

[15]  M. Borowitz,et al.  Favorable prognosis associated with hyperdiploidy in children with acute lymphocytic leukemia correlates with extra chromosome 6. A pediatric oncology group study , 1990, Cancer.

[16]  N. Heerema.  Cytogenetic abnormalities and molecular markers of acute lymphoblastic leukemia. , 1990, Hematology/oncology clinics of North America.

[17]  C. Berard,et al.  Presence of clonal chromosome abnormalities in virtually all cases of acute lymphoblastic leukemia. , 1985, The New England journal of medicine.

[18]  S. O’Brien,et al.  The human erg gene maps to chromosome 21, band q22: relationship to the 8; 21 translocation of acute myelogenous leukemia. , 1988, Oncogene.

[19]  J. Rowley,et al.  Chromosome abnormalities in malignant hematologic diseases. , 1982, Advances in cancer research.

[20]  H. Gralnick,et al.  Proposals for the Classification of the Acute Leukaemias French‐American‐British (FAB) Co‐operative Group , 1976, British journal of haematology.

[21]  Iscn.  International System for Human Cytogenetic Nomenclature , 1978 .

[22]  L. Secker-Walker.  Prognostic and biological importance of chromosome findings in acute lymphoblastic leukemia. , 1990, Cancer genetics and cytogenetics.

[23]  W. S. Hayward,et al.  Two human c-onc genes are located on the long arm of chromosome 8. , 1982, Proceedings of the National Academy of Sciences of the United States of America.

[24]  M. Caballín,et al.  Acute lymphoblastic leukemia with t(4;11) in a patient previously exposed to a carcinogen. , 1990, Cancer genetics and cytogenetics.

[25]  K. Miyamoto,et al.  Chromosome abnormalities of leukemia cells in adult patients with T-cell leukemia. , 1984, Journal of the National Cancer Institute.