The Hematological Complications of Alcoholism

Alcohol has numerous adverse effects on the various types of blood cells and their functions. For example, heavy alcohol consumption can cause generalized suppression of blood cell production and the production of structurally abnormal blood cell precursors that cannot mature into functional cells. Alcoholics frequently have defective red blood cells that are destroyed prematurely, possibly resulting in anemia. Alcohol also interferes with the production and function of white blood cells, especially those that defend the body against invading bacteria. Consequently, alcoholics frequently suffer from bacterial infections. Finally, alcohol adversely affects the platelets and other components of the blood-clotting system. Heavy alcohol consumption thus may increase the drinker’s risk of suffering a stroke.

[1]  R. Anton,et al.  The use of carbohydrate deficient transferrin as an indicator of alcohol consumption during treatment and follow-up. , 1996, Alcoholism, clinical and experimental research.

[2]  N. Pellegrini,et al.  Effects of moderate consumption of red wine on platelet aggregation and haemostatic variables in healthy volunteers. , 1996, European journal of clinical nutrition.

[3]  E. Nilsson,et al.  Ethanol affects leukotriene generation and leukotriene-induced functional responses in human polymorphonuclear granulocytes. , 1995, Scandinavian journal of clinical and laboratory investigation.

[4]  A. Myers,et al.  Inhibition of platelet aggregation in whole blood by alcohol. , 1995, Thrombosis research.

[5]  N. Abumrad,et al.  Granulocyte colony-stimulating factor prevents ethanol-induced impairment in host defense in septic rats. , 1993, Alcoholism, clinical and experimental research.

[6]  Harold S. Ballard Hematological complications of alcoholism. , 1989, Alcoholism, clinical and experimental research.

[7]  John Lindenbaum Hematologic Complications of Alcohol Abuse , 1987, Seminars in liver disease.

[8]  D. Savage,et al.  Anemia in Alcoholics , 1986, Medicine.

[9]  L. Kricka,et al.  MORPHOLOGY OF RED BLOOD CELLS IN ALCOHOLICS , 1984, The Lancet.

[10]  C. C. Douglass,et al.  Transient stomatocytosis with hemolysis: a previously unrecognized complication of alcoholism. , 1970, Annals of internal medicine.

[11]  J. Lindenbaum,et al.  Thrombocytopenia in alcoholics. , 1968, Annals of internal medicine.

[12]  W. Mcfarland,et al.  ABNORMAL LEUKOCYTE RESPONSE IN ALCOHOLISM. , 1963, Annals of internal medicine.

[13]  P. Sillanaukee,et al.  Evaluation of macrocytosis by general practitioners. , 1996, Journal of studies on alcohol.

[14]  R. Deitrich,et al.  Pharmacological effects of ethanol on the nervous system , 1996 .

[15]  B. Tabakoff,et al.  The Search for Biochemical Markers , 1995, Alcohol health and research world.

[16]  A. Rosman,et al.  Biological Markers of Alcoholism , 1992 .