Cholecystokinin inhibits tail pinch-induced eating in rats.

Peripheral administration of the COOH-terminal octapeptide of cholecystokinin in doses from 1 to 100 micrograms per kilogram of body weight (0.25 to 25.0 micrograms per rat) significantly antagonized tail pinch-induced eating in rats, an animal model for stress-induced human hyperphagia. Centrally administered cholecystokinin was effective only in high doses (3 micrograms into the cerebral ventricle). The finding that the minimal effective dose of cholecystokinin in suppressing stress-induced appetitive behavior is smaller after peripheral than central administration suggests that the peptide is acting on peripheral, as opposed to central nervous system, substrates.

[1]  R. Young,et al.  Cholecystokinin elicits Satiety in Rats with Open Gastric Fistulas , 1973, Nature.

[2]  G. Dockray,et al.  Immunochemical evidence of cholecystokinin-like peptides in brain , 1976, Nature.

[3]  S. Iversen,et al.  Tail-pinch stimulation: sufficient motivation for learning. , 1976, Science.

[4]  G. P. Smith,et al.  Cholecystokinin decreases food intake in rats. , 1973, Journal of comparative and physiological psychology.

[5]  N. Rowland,et al.  Stress-induced hyperphagia and obesity in rats: a possible model for understanding human obesity. , 1976, Science.

[6]  A. E. Fisher,et al.  Tail pinch-induced eating, gnawing and licking behavior in rats: Dependence on the nigrostriatal dopamine system , 1975, Brain Research.

[7]  G. Makhlouf,et al.  The neuroendocrine design of the gut. The play of chemicals in a chemical playground. , 1974, Gastroenterology.

[8]  R. Yalow,et al.  Immunohistochemical localization in rabbit brain of a peptide resembling the COOH-terminal octapeptide of cholecystokinin. , 1977, Proceedings of the National Academy of Sciences of the United States of America.

[9]  E. Stricker,et al.  The physiological psychology of hunger: a physiological perspective. , 1976, Psychological review.

[10]  H. Szechtman,et al.  Tail pinch induces eating in sated rats which appears to depend on nigrostriatal dopamine. , 1975, Science.

[11]  R. Yalow,et al.  Cholecystokinin and its COOH-terminal octapeptide in the pig brain. , 1977, Proceedings of the National Academy of Sciences of the United States of America.

[12]  G. P. Smith,et al.  Cholecystokinin does not produce bait shyness in rats. , 1974, Physiology & behavior.

[13]  A. Schally,et al.  Enterogastrone Inhibits Eating by Fasted Mice , 1967, Science.

[14]  J. C. Zimmerman,et al.  Cholecystokinin-induced satiety in weanling rats , 1976, Physiology & Behavior.

[15]  E. Mufson,et al.  Tail pinch-induced arousal and stimulus-bound behavior in rats with lateral hypothalamic lesions. Further evaluation of hypothalamic control of feeding and drinking. , 1976, Brain, behavior and evolution.

[16]  R. Sturdevant,et al.  Cholecystokinin both stimulates and inhibits human food intake , 1976, Nature.